To determine the minimum and reasonable radius of horizontal curve for reducing wheel wear in heavy-haul railway design, a HXD locomotive with the wheel arrangement of C0-C0 is taken as the research object. Both the corresponding locomotive dynamic model and wheel wear model are established. Based on the measured wear data in a specific line, the simulation model is verified with the prediction error of wheel wear depth below 0.5 mm in general. The wheel wear evolution rules in 400∼1000m radius curves are studied and compared. The results indicate that, the wheel wear is large and sensitive to curve radius within 400∼600 m. The larger radius curve will be helpful to reduce wheel flange contact and wheel wear. For curve radius increasing from 600m to 1000m, the wheel average wear reduces slowly. Especially for curve radius below around 740 m, the wheel flange wear will be predominant. For radius above 740m, the wheel tread wear becomes the main wear form and the wheel flange wear can be reduced significantly. The increase of curve radius will also improve the wheel-rail equivalent conicity. If the minimum curve radius is set as 800m, the equivalent conicity difference between new wheelset and 1st ∼ 3rd worn wheelset can be kept below 21%, 52% and 9% respectively. In this case, the equivalent conicity is closest to the initial state and reaches a steady state, which will not change significantly with the radius further increasing. Viewed from the aspects of reducing wheel wear, avoiding wheel flange contact and keeping conicity stable simultaneously, the minimum radius of horizontal curve should be limited to 800 m. The research results validate the minimum curve radius suggested in Code for Design of Heavy-haul Railway in China, and provide a scientific explanation for the determination of this value.