Excellent wear resistance is an essential characteristic of UHMWPE being used in biomedical applications such as knee and hip implants. The two popular techniques to enhance the wear resistance of UHMWPE are cross-linking enhancement using UV irradiation and fabrication of composite using stiffed reinforcement. This manuscript compared the wear rate of UV irradiated UHMWPE and nHA reinforced UHMWPE composite by sliding against the CoCr alloy for a distance of 1500 m under dry conditions. The applied load was 40 N during the test. The wear rate reductions of 51% and 56% were recorded in UHMWPE/20 nHA composite, and UV irradiated UHMWPE, respectively. The obtained results claimed that UV irradiated UHMWPE is a better tribo-pairs for biomedical applications over UHMWPE/20 nHA because the wear resistance was compromised by third body wear caused due to the released hard nHA debris from UHMWPE/20 nHA composite. The biological responses of the specimens were evaluated by hemolysis assay and platelet adhesion on the specimen surface. Cellular compatibility has been studied by assessing the percentage cell viability of peripheral blood mononuclear cells on the specimen surface. In vitro degradation was performed under a simulated blood fluid environment.