Climate change and variability pose significant challenges to cocoa production in many sub-Saharan African countries, and Ghana is no exception. Therefore, knowledge of how farmers react to climate change and its variability effects is crucial in developing policies and programs to guide the design and implementation of effective climate-smart adaptation strategies at the farm level in Africa. This study aims to examine climate-smart adaptation choices cocoa farmers make as coping strategies for climate change and variability in Ghana using a multivariate probit modeling approach. Following a multistage sampling procedure, primary data was collected from 720 cocoa farmers across the major cocoa-growing regions in Ghana. The study found major adaptation choices for cocoa farmers to include improved and resistant varieties, optimal fertilizer application, optimal pesticide application, adjusting planting/harvesting dates, shade tree management, crop diversification, non-crop diversification, and off-farm economic diversification. We further observed that farmers’ adaptation choices were significantly influenced by climate change and adaptation-related variables such as rainfall variability index, temperature variability index, climate change impact perception index, and CSA awareness as well as agroclimatic zone effects. Concerning the influence of farmer and farm-specific variables, the study identifies that sex, age, education, farm size, quality of extension services delivery, access to credit, and membership in farmer groups were significant predictors of farmers’ CSA decision choices. This study offers beneficial insights for policymakers and stakeholders on how to promote climate-smart adaptation methods among cocoa farmers in Ghana.