Cocculus Hirsutus Research Articles

CAMBIAL VARIANT AND XYLEM STRUCTURE IN THE STEM OF COCCULUS HIRSUTUS (MENISPERMACEAE)

Development of cambial variant and xylem structure were studied in the stem of Cocculus hirsutus (Menispermaceae). In the early stages of stem development several collateral vascular bundles are joined by interfascicular cambium resulting in the formation of a complete cambial cylinder. After functioning for two to three years the cambial ring ceases its activity. Subsequently a second ring of cambium is formed from the innermost cortical parenchyma cells. These parenchyma cells undergo periclinal divisions to give rise to cells that become lignified, abaxially, and cambial cells, adaxially. The cambial cells divide periclinally giving rise to individual vascular bundles with xylem and phloem. Later the cambium in each bundle is joined by interfascicular cambium. Subsequent cambia develop similarly resulting in the formation of successive rings of xylem and phloem. During the leafless condition, all the cambial rings are dormant, and flanked by mature xylem and phloem elements. With the sprouting of new leaves, either the existing outermost cambium reactivates or an entire new ring of cambium develops. The xylem is diffuseporous with indistinct growth rings. It is composed of fibre-tracheids, tracheids, vessel elements, libriform fibres, and parenchyma cells. Xylem rays are multiseriate, compound and heterocellular. Deformed libriform fibres and vessel elements commonly occur among the ray cells in all the successive rings of xylem. The length of fibres and the height and width of xylem rays increase gradually from the centre towards the periphery of the stem.

Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts

The aqueous extract of the Cocculus hirsutus aerial parts (100 and 200 mg/kg, p.o.) showed significant diuretic activity and laxative effect in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg.

Jamtinine, an alkaloid from Cocculus hirsutus

A new alkaloid, jamtinine, was isolated from Cocculus hirsutus. Its structure is assigned on the basis of chemical and spectral studies.

Haiderine, a New Isoquinoline Alkaloid FromCocculus hirsutus

Abstract A new isoquinoline alkaloid, haiderine (1), was isolated from aerial parts of Cocculus hirsutus together with eleven known alkaloids. The structure of (1), was determined by spectroscopic methods and by chemical transformations.

Hirsutine: A New Alkaloid from Cocculus hirsutus

A new alkaloid, hirsutine, was isolated from Cocculus hirsutus. Its structure has been assigned as 1 on the basis of chemical and spectral studies

Cohirsinine, an alkaloid from Cocculus hirsutus

A new alkaloid, cohirsinine, was isolated from Cocculus hirsutus. Its structure is assigned on the basis of chemical and spectral studies.

Hirsudiol a triterpenoid from cocculus hirsutus

A new triterpenoid alcohol hirsudiol, has been isolated from Cocculus hirsutus. Its structure was determined as 2α,3α-dihydroxyolean-13(18)-ene through spectroscopic studies. Nonacosan-10-ol was also isolated.

Cohirsine - a novel isoquinolone alkaloid from [formula omitted

A novel alkaloid, cohirsine (1) was isolated from Cocculus hirsutus . Its structure has been investigated by extensive NMR studies including 2D NMR experiments. Its stereochemistry has been determined by 2D NOESY and NOE difference measurements.