Abstract Ecosystem-based management (EBM) is a landscape-level management and planning process that is common across North America. A primary tenet of EBM is that the area and intensity of anthropogenic disturbance should mimic the historical natural disturbance of the focal ecosystem. Biodiversity should persist, at least at a coarse scale, where anthropogenic disturbance, such as forest harvesting, matches natural disturbance. However, EBM is failing some species, particularly those that are dependent on old forest. Across many areas of Canada, woodland caribou (Rangifer tarandus caribou) are declining because of the direct and indirect effects of habitat loss and fragmentation. This is even though forest management often follows the principles of EBM. We conducted a qualitative comparison of the responses of woodland caribou to wildfire and forest harvesting, considering a broad range of responses, including habitat selection and distribution, forage, movement patterns, and population dynamics. We found that while wildfire and forest harvesting both influence caribou, the negative effects are generally greater following forest harvesting. For example, wildfire and forest harvesting result in the loss of habitat, but caribou are more likely to shift, abandon or contract their range in response to harvest. The literature also suggested a stronger negative population response of caribou to forest harvest when compared to wildfire. This difference could be the result of greater residual forest structure associated with wildfire as well as the extensive resource roads that are necessary for forestry operations. Although there is sound theoretical support for EBM, the practice, as implemented, may not be effective for maintaining the habitat and ultimately populations of woodland caribou.