To reduce manufacturing costs, energy companies aim to maximize the deposition rate during welding operations by increasing the interpass temperature (IT), thereby minimizing the cooling time. However, IT can significantly affect weldment performance, particularly its Charpy V-notch (CVN) impact energy (toughness). The present study investigates the effect of increasing IT beyond the limit specified by the ASME B31.3 (315 °C) on the CVN impact energy (−30 °C) of the simulated coarse-grained heat-affected zone (CGHAZ) of a 2.25Cr-1Mo steel submerged arc welded (SAW). The CGHAZ thermal cycles were obtained through finite element method simulations and physically replicated using a Gleeble machine. The increase in IT beyond the ASME-specified limit significantly reduces the CVN impact energy of the CGHAZ. However, the values obtained remained above the minimum required threshold (NORSOK M630, 42 J). The main effect of increased IT was grain coarsening. Additionally, an inverse linear relationship was observed between effective grain size (EGS) and CVN impact energy. The steel’s microstructure showed non-significant sensitivity to variations in IT within the studied range. These findings suggest that, under the conditions studied, increasing IT could be a viable option for optimizing production by reducing welding time and potentially lowering costs.