Coalbed fracturing is one of the important engineering and technical means of coalbed methane stimulation. To establish the seepage model of coalbed gas fracturing well is the key scientific problem to effectively evaluate the fracturing effect. Therefore, based on the micro pore structure of coalbed methane, this paper constructs the physical model of three porosity and two permeability, the mathematical model of seepage and the mathematical model of bottom hole pressure response, and analyzes the key factors affecting the dynamic response characteristics of pressure. The results show that diffusion coefficient, channeling coefficient, reservoir volume ratio and conductivity have different effects on the bottom hole pressure of the vertical well of three hole and two permeability fracturing. The results of this paper have certain guiding significance for the drainage and production capacity prediction of coalbed methane.