Objective: To analyze the major occupational disease surveillance and the occupational health examination of Jining in 2018, provide the basis for the government department formulating occupational disease prevention measures. Methods: In January 2019, collecting data of the occupational disease and Occupational Health Information Surveillance Network in Jining from January 1 to December 31, 2018, 37295 workers were collected, and 37295 workers who were exposed to key occupational disease risk factors and underwent occupational health check-up during their working period. The contact of occupational Hazard Factors and occupational health examination were analyzed. SPSS 22.0 was used to set up the database for statistical analysis. Results: Workers exposed to major occupational hazards were more exposed to noise (56.34%, 39935/70883) , coal dust (15.65%, 11095/70883) , welding fume (10.25%, 7262/70883) , silicon dust (5.61%, 3975/70883) . In 2018, 24 cases (38.71%, 2462) of coal worker's pneumoconiosis, 21 cases (33.87%, 2162) of silicosis, 8 cases (12.90%, 82) of noise deafness and 8 cases (12.90%, 862) of brucellosis were the major occupational diseases reported. The abnormal rate of lung function examination was 14.87% (461/3100) , and the abnormal rate of high frequency hearing threshold examination was 4.56% (1492/32731) in workers exposed to coal dust (coal-silica dust) , the difference was statistically significant (P<0.01) . Conclusion: Jining should strengthen the supervision of enterprises with key occupational disease hazards, formulate classified supervision and management methods, and improve the occupational health inspection rate of workers.