The development of electrical engineering and electronic, communications, smart power grid, and ultra-high voltage transmission technologies have driven the energy system revolution to the next generation: the energy internet. Progressive penetration of intermittent renewable energy sources into the energy system has led to unprecedented challenges to the currently wide use of coal-fired power generation technologies. Here, the applications and prospects of advanced coal-fired power generation technologies are analyzed. These technologies can be summarized into three categories: (1) large-scale and higher parameters coal-fired power generation technologies, including 620/650/700 °C ultra-supercritical thermal power and double reheat ultra-supercritical coal-fired power generation technologies; (2) system innovation and specific, high- efficiency thermal cycles, which consist of renewable energy-aided coal-fired power generation technologies, a supercritical CO2 Brayton cycle for coal-fired power plants, large-scale air-cooling coal-fired power plant technologies, and innovative layouts for waste heat utilization and enhanced energy cascade utilization; (3) coal-fired power generation combined with poly-generation technologies, which are represented by integrated gasification combined cycle (IGCC) and integrated gasification fuel cell (IGFC) technologies. Concerning the existing coal-fired power units, which are responsible for peak shaving, possible strategies for enhancing flexibility and operational stability are discussed. Furthermore, future trends for coal-fired power plants coupled with cyber-physical system (CPS) technologies are introduced. The development of advanced, coal-fired power generation technologies demonstrates the progress of science and is suitable for the sustainable development of human society.