In recent years, the quality of the surface water of the city of Fez has deteriorated due to the development of various anthropic activities, ill-considered modernization, unregulated discharge of wastewater and solid waste. This is a worrying threat to human health and the environment. Previous studies on these wadis have shown that Tghat and Zhoun wadis are the most polluted [1]; [2]; [3]. Adequate treatment of effluents upstream is therefore of crucial importance. The objective of this study is to contribute to the treatment of endocrine pollutants discharged upstream of these two wadis after their characterization and monitoring of their pollutant load for six months (El Madani et al., 2019). The most polluted wadis of the city of Fez [2] by coagulation-flocculation.The results showed that these effluents have a medium faecal load and are loaded by organic pollution at the limit of biodegradability rich in nitrogen and phosphorus matter and a high metallic load with endocrine disrupting effect, mainly Cr, As, Pb and Cd.The treatment of these pollutants by coagulation-flocculation with aluminum sulphate of the effluents studied under optimal conditions of pH, a dose of coagulant and flocculant and coagulation and flocculation agitation speeds, allowed the reduction of almost all the organic matter and 90 to 96% of the metal load.