Aiming to reduce the use of conventional energy sources, alternative methods should be applied in order to cover society’s needs. In this context, in the present study, the operation of a transcritical CO2 commercial refrigeration unit is investigated, coupled with two power production cycles. The first cycle is a supercritical CO2 Brayton system that is supplied with heat by a solar field including parabolic trough collectors, while the second one is an organic Rankine cycle, utilizing as a heat source the low enthalpy CO2 exiting the first cycle. The novelty of this system is attributed to the combination an advanced transcritical CO2 refrigeration system with power production cycles that operate under the optimal conditions, as well as to the reason that the operation of the refrigeration unit is independent from the solar energy, since it can provide refrigeration output regardless of the solar heat input. The results prove that the increased number of solar collectors leads to more advantageous power production results, although with higher capital costs. Furthermore, greater energy production is noted when the ambient temperature is lower and abundant solar power is available. For the case of installing five solar collectors and an organic Rankine cycle, it is found that the annual energy production of the total system is 173.72 MWh, while the annual energy consumption of the refrigeration unit is 466.66 MWh, meaning that 37.23 % of energy savings are achieved annually. For the same configuration, according to the life cycle cost analysis, the capital cost is found equal to 243.72 k€, leading to a payback period of 7.6 years. By the end of the project’s lifetime, the operation of the installed system returns 298.42 k€ to the investor.