Although CO2-responsive gel particles (CRGP) injection appears to be a viable strategy for delaying CO2 breakthrough in fractured ultra-low permeability reservoirs, few studies have been conducted to thoroughly evaluate the injectivity and plugging characteristics of CRGP. In the present work, the swelling kinetics of the CRGP at various temperatures and salinities were first characterized through the change in CRGP volume. The rheology properties of CRGP dispersion solution were then evaluated. And then, taking the resistance coefficient, residual resistance coefficient and plugging rate as indexes, the effect of matching coefficient, injection rate, and injection concentration on CRGP injectivity and plugging characteristics was investigated using simulated artificial fractures. Finally, the empirical correlations of injectivity and plugging characteristics parameters were established. According to experimental result, the equilibrium swelling ratio of CRGP was greater than 40-fold at varied salinity conditions. The shear-thinning capabilities of the CRGP dispersion solution, as well as its favorable storage modulus, endowed CRGP with favorable in-depth migration and plugging properties. In addition, in terms of fracture plugging by CRGP, the plugging ratio of CRGP in fractures was higher than 90% when the matching coefficient ranged from 1.0 to 2.0, the injection rate was less than 0.5 mL/min, and CRGP concentration was larger than 3000 mg/L. The acquired empirical relationships were expected to guide the selection of CRGP size, injection concentration, and injection rate for fracture plugging.