The current scenario of dentistry focuses on regeneration for bony defects and associated disorders. For this a thorough understanding of biological and molecular sciences is required. Bone substitutes natural or synthetic act as fillers and scaffolds to regenerate bone and stimulate wound healing. A variety of bone grafts are used in dental practice the most common being alloplasts synthetic bone grafts. Globally 2.2 million bone grafts are placed every year. However there are several challenges yet to overcome. Modifications of existing bone grafts continues to be an expanding subject of interest. Poly DL-lactic co-glycolic acid PLGA - a copolymer of lactic acid and glycolic acid is the rising star in regenerative science which is a complex field. This composite biomaterial retains the properties of both the monomers and can be modified and manipulated into desired forms. Initially PLGA was a desirable candidate for carrier of drug peptides and proteins delivery. Owing to the versatile properties of PLGA it has currently encroached various pharmaceutics medical and dental arenas. This material has been approved by US FDA Food and drug administration as a bone graft substitute. It is believed that PLGA scaffolds can generate osteoconductive and osteoinductive gradient useful for bone formation. This polymer offers the advantages of controlled degradation biocompatibility tunable physiochemical properties and ability to regenerate bone tissues. Also it demonstrates low toxicity in biological tissues. More recently it has revealed its potential as scaffolds 3D printed platforms hydrogels fibers microspheres and nanoparticles. This literature review elaborates the implications of PLGA in regeneration therapy.