Cooperation In Science And Technology Research Articles

Complete Genome Sequence Resource for Xanthomonas translucens pv. undulosa MAI5034, a Wheat Pathogen from Uruguay.

Complete Genome Sequence Resource for Xanthomonas translucens pv. undulosa MAI5034, a Wheat Pathogen from Uruguay.

Comparison of numerical analyses of a composite wing component subjected to 4-point bending

In this paper, a comparison between six finite element models of a representative wing structural component performed in the context of Optimised Design for Inspection (ODIN) project of the European Cooperation in Science and Technology (COST) is presented. Six partners from six different countries involved in the project received the drawing of the structure, the material properties, the loading and boundary conditions. Each partner, based on their background and experience in numerical analyses, developed a finite element model with different levels of details and accuracy and performed a blind prediction of the structural behaviour of the wing component. The numerical results are presented and compared with the experimental test data conducted at Cardiff University.

Plasma‐driven biocatalysis: In situ hydrogen peroxide production with an atmospheric pressure plasma jet increases the performance of OleTJE when compared to adding the same molar amount of hydrogen peroxide in bolus

AbstractEnzymes like fatty acid peroxygenase OleTJE are desirable enzymes for the industry. While they require inexpensive hydrogen peroxide for activity, the same hydrogen peroxide also causes overoxidation of their reactive heme center. Here, we generate hydrogen peroxide slowly in situ using the Cooperation in Science and Technology (COST)‐Jet, an atmospheric pressure plasma jet, to avoid overoxidizing OleTJE. The COST‐Jet was operated in helium with a water admixture to provide hydrogen peroxide for OleTJE activity. This helium/water admixture produced the highest enzyme turnover numbers after 2 min of treatment. These turnover numbers were even superior to using an equimolar amount of hydrogen peroxide to treat the enzymes exogenously, showing that this plasma source can provide a reliable amount of reaction mediator to support OleTJE activity.

Conditions that do or do not disadvantage interdisciplinary research proposals in project evaluation

AbstractDespite interdisciplinary research playing a pivotal role in modern science, interdisciplinary research proposals appear to have a lower chance of being funded. Scholars suggested that interdisciplinary research may be disadvantaged in the evaluation and should be earmarked specific resources and evaluated by specific panels. However, empirical evidence is limited regarding the conditions under which interdisciplinary proposals are disadvantaged. We explore this issue in the context of the European Cooperation in Science and Technology (COST) research funding framework, which, contrary to the common practice, does not organize the evaluation process around disciplinary panels, but with a panel‐free system. The sample includes data from five calls, from March 2015 to September 2017, for a total of 1,928 proposals, and 5,330 evaluations conducted by 3,050 reviewers. We find that the effect of a proposal’s degree of interdisciplinarity is negligible and not significant. We found no variation in this result across scientific fields and disciplinary expertise of reviewers, and no evidence of disciplinary “turf wars.” These results suggest that factors assumed to disadvantage interdisciplinary proposals, such as being inherently more challenging to be evaluated and being riskier, are less problematic when the evaluation is not organized around disciplinary panels but rather with a panel‐free system.

POSA355 Pan-European Study on the Management of Medication Adherence: A Study Protocol By Cost Action 'Enable' Working Group 1

The European Cooperation in Science and Technology (COST) project “European Network to Advance Best practices & technoLogy on medication adherencE” (ENABLE) aims at raising awareness and broadening knowledge on medication adherence (MA). First task of ENABLE Work Group 1 is to collect information on the management of MA across Europe.

Creating the European Literary Text Collection (ELTeC): Challenges and Perspectives

The aim of this contribution is to reflect on the process of building the multilingual <em>European Literary Text Collection</em> (ELTeC) that is being created in the framework of the networking project <em>Distant Reading for European Literary History</em> funded by COST (European Cooperation in Science and Technology). To provide some background, we briefly introduce the basic idea of ELTeC with a focus on the overall goals and intended usage scenarios. We then describe the collection composition principles that we have derived from the usage scenarios. In our discussion of the corpus-building process, we focus on collections of novels from four different literary traditions as components of ELTeC: French, Portuguese, Romanian, and Slovenian, selected from the more than twenty collections that are currently in preparation. For each collection, we describe some of the challenges we have encountered and the solutions developed while building ELTeC. In each case, the literary tradition, the history of the language, the current state of digitization of cultural heritage, the resources available locally, and the scholars’ training level with regard to digitization and corpus building have been vastly different. How can we, in this context, hope to build comparable collections of novels that can usefully be integrated into a multilingual resource such as ELTeC and used in Distant Reading research? Based on our individual and collective experience with contributing to ELTeC, we end this contribution with some lessons learned regarding collaborative, multilingual corpus building.

Management of Urban Waters with Nature-Based Solutions in Circular Cities—Exemplified through Seven Urban Circularity Challenges

Nature-Based Solutions (NBS) have been proven to effectively mitigate and solve resource depletion and climate-related challenges in urban areas. The COST (Cooperation in Science and Technology) Action CA17133 entitled “Implementing nature-based solutions (NBS) for building a resourceful circular city” has established seven urban circularity challenges (UCC) that can be addressed effectively with NBS. This paper presents the outcomes of five elucidation workshops with more than 20 European experts from different backgrounds. These international workshops were used to examine the effectiveness of NBS to address UCC and foster NBS implementation towards circular urban water management. A major outcome was the identification of the two most relevant challenges for water resources in urban areas: ‘Restoring and maintaining the water cycle’ (UCC1) and ‘Water and waste treatment, recovery, and reuse’ (UCC2). s Moreover, significant synergies with ‘Nutrient recovery and reuse’, ‘Material recovery and reuse’, ‘Food and biomass production’, ‘Energy efficiency and recovery’, and ‘Building system recovery’ were identified. Additionally, the paper presents real-life case studies to demonstrate how different NBS and supporting units can contribute to the UCC. Finally, a case-based semi-quantitative assessment of the presented NBS was performed. Most notably, this paper identifies the most typically employed NBS that enable processes for UCC1 and UCC2. While current consensus is well established by experts in individual NBS, we presently highlight the potential to address UCC by combining different NBS and synergize enabling processes. This study presents a new paradigm and aims to enhance awareness on the ability of NBS to solve multiple urban circularity issues.

Analysis Of Quality Control Plans For Bridge Over The River Maza Jugla Accoring To COST TU 1406 Methodology

Bridges are one of the most expensive elements of the road network, and therefore in the bridge management process, it is very important to make the most technically efficient and cost-effective decisions about planned actions such as maintenance, rehabilitation and reconstruction works. Decisions have to be based both on the current situation and possible future options and alternatives.The European Cooperation in Science and Technology (COST) during the action TU 1406 “Quality specifications for roadway bridges, standardization at a European level (BridgeSpecs)” in the period from 2014 to 2019 has developed the framework for the development of bridge Quality Control Plans (QCP) including the system of data collection, data processing and outcomes.This article analyses and compares different Quality Control Plans developed according to COST TU 1406 methodology for the existing bridge over the river Maza Jugla, located on regional road P10 at km 34.80 in Latvia.

UNGAP best practice for improving solubility data quality of orally administered drugs

An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral drug absorption. Solubility is a general term that refers to the maximum achievable concentration of a compound dissolved in a liquid medium. For orally administered drugs, relevant information on drug properties is crucial during drug (product) development and at the regulatory level. Collection of reliable and reproducible solubility data requires careful application and understanding of the limitations of the selected experimental method. In addition, the purity of a compound and its solid state form, as well as experimental parameters such as temperature of experimentation, media related factors, and sample handling procedures can affect data quality. In this paper, an international consensus developed by the COST UNGAP network on recommendations for collecting high quality solubility data for the development of orally administered drugs is proposed.

Positive Energy Districts: Identifying Challenges and Interdependencies

Positive Energy Districts (PED) are areas within cities that generate more renewable energy than they consume, contributing to cities’ energy system transformation toward carbon neutrality. Since PED is a novel concept, the implementation is very challenging. Within the European Cooperation in Science and Technology (COST) Action, which offers an open space for collaboration among scientists across Europe (and beyond), this paper asks what the needs for supporting the implementation of PEDs are. To answer this, it draws on Delphi process (expert reviews) as the main method alongside the literature review and also uses surveys as supplementary methods to identify the main challenges for developing PEDs. Initial findings reveal seven interacting topics that later were ranked as highest to the lowest as the following: governance, incentive, social, process, market, technology and context. These are interrelated and interdependent, implying that none can be considered in isolation of the others and cannot be left out in order to ensure the successful development of PEDs. The resources that are needed to address these challenges are a common need for systematic understanding of the processes behind them, as well as cross-disciplinary models and protocols to manage the complexity of developing PEDs. The results can be the basis for devising the conceptual framework on the development of new PED guides and tools.

Mediators and Theories of Change in Psychotherapy for Young People With Personality Disorders: A Systematic Review Protocol.

Background: Personality disorders (PDs) are a severe health issue already prevalent among adolescents and young adults. Early detection and intervention offer the opportunity to reduce disease burden and chronicity of symptoms and to enhance long-term functional outcomes. While psychological treatments for PDs have been shown to be effective for young people, the mediators and specific change mechanisms of treatment are still unclear.Aim: As part of the “European Network of Individualized Psychotherapy Treatment of Young People with Mental Disorders” (TREATme), funded by the European Cooperation in Science and Technology (COST), we will conduct a systematic review to summarize the existing knowledge on mediators of treatment outcome and theories of change in psychotherapy for young people with personality disorders. In particular, we will evaluate whether mediators appear to be common or specific to particular age groups, treatment models, or outcome domains (e.g., psychosocial functioning, life quality, and adverse treatment effects).Method: We will follow the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. Electronic databases (PubMed and PsycINFO) have been systematically searched for prospective, longitudinal, and case–control designs of psychological treatment studies, which examine mediators published in English. Participants will be young people between 10 and 30years of age who suffer from subclinical personality symptoms or have a personality disorder diagnosis and receive an intervention that aims at preventing, ameliorating, and/or treating psychological problems.Results: The results will be published in a peer-reviewed journal and at conference presentations and will be shared with relevant stakeholder groups. The data set will be made available to other research groups following recommendations of the open science initiative. Databases with the systematic search will be made openly available following open science initiatives. The review has been registered in PROSPERO (evaluation is pending, registration number ID 248959).Implications: This review will deliver a comprehensive overview on the empirical basis to contribute to the further development of psychological treatments for young people with personality disorders.

Towards a COST MOBILISE Guideline for Long Term Preservation and Archiving of Data Constructs from Scientific Collections Facilities

COST (European Cooperation in Science and Technology) is a funding organisation for research and innovation networks. One of the objectives of the COSTAction called “Mobilising Data, Policies and Experts in Scientific Collections“ (MOBILISE) is to work on documents for expert training with broad involvement of professionals from the participating European countries. The guideline presented here in its general concept will address principles, strategies and standards for long term preservation and archiving of data constructs (data packages, data products) as addressed by and under control of the scientific collections community. The document is being developed as part of the MOBILISE Action targeted towards primarily scientific staff at natural scientific collection facilities, as well as management bodies of collections like museums, herbaria and information technology personnel less familiar with data archiving principles and routines. The challenges of big data storage and (distributed, cloud-based) storage solutions as well as that of data mirroring, backing up, synchronisation and publication in productive data environments are well addressed by documents, guidelines and online platforms, e.g., in the DISSCo knowledge base (see Hardisty et al. (2020)) and as part of concepts of the European Open Science Cloud (EOSC). Archival processes and the resulting data constructs, however, are often left outside of the considerations. This is a large gap because archival issues are not only simple technical ones as addressed by the term “bit preservation” but also envisage a number of logical, functional, normative, administrative and semantic issues as addressed by the term “functional long-term archiving”. The main target digital object types addressed by this COST MOBILISE Guideline are data constructs called Digital or Digital Extended Specimens and data products with the persistent identifier assignment lying under the authority of scientific collections facilities. Such digital objects are specified according to the Digital Object Architecture (DOA , see Wittenburg et al. 2018) and similar abstract models introduced by Harjes et al. (2020) and Lannom et al. (2020). The scientific collection-specific types are defined following evolving concepts in the context of the Consortium of European Taxonomic Facilities (CETAF), the research infrastructure DiSSCo (Distributed System of Scientific Collections), and the Biodiversity Information Standards (TDWG). Archival processes are described following the OAIS (Open Archival Information System) reference model. The archived objects should be reusable in the sense of the FAIR (Findable, Accessible, Interoperable, and Reusable) guiding principles. Organisations like national (digital) archives, computing or professional (domain-specific) data centers as well as libraries might offer specific archiving services and act as partner organisations of scientific collections facilities. The guideline consists of key messages that have been defined. They address the collection community, especially the staff and leadership of taxonomic facilities. Aspects of several groups of stakeholders are discussed as well as cost models. The guideline does not recommend specific solutions for archiving software and workflows. Supplementary information is delivered via a wiki-based platform for the COST MOBILISE Archiving Working Group WG4.

The "GEnomics of Musculo Skeletal Traits TranslatiOnal NEtwork": Origins, Rationale, Organization, and Prospects.

Musculoskeletal research has been enriched in the past ten years with a great wealth of new discoveries arising from genome wide association studies (GWAS). In addition to the novel factors identified by GWAS, the advent of whole-genome and whole-exome sequencing efforts in family based studies has also identified new genes and pathways. However, the function and the mechanisms by which such genes influence clinical traits remain largely unknown. There is imperative need to bring multidisciplinary expertise together that will allow translating these genomic discoveries into useful clinical applications with the potential of improving patient care. Therefore “GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork” (GEMSTONE) aims to set the ground for the: 1) functional characterization of discovered genes and pathways; 2) understanding of the correspondence between molecular and clinical assessments; and 3) implementation of novel methodological approaches. This research network is funded by The European Cooperation in Science and Technology (COST). GEMSTONE includes six working groups (WG), each with specific objectives: WG1-Study populations and expertise groups: creating, maintaining and updating an inventory of experts and resources (studies and datasets) participating in the network, helping to assemble focus groups defined by phenotype, functional and methodological expertise. WG2-Phenotyping: describe ways to decompose the phenotypes of the different functional studies into meaningful components that will aid the interpretation of identified biological pathways. WG3 Monogenic conditions - human KO models: makes an inventory of genes underlying musculoskeletal monogenic conditions that aids the assignment of genes to GWAS signals and prioritizing GWAS genes as candidates responsible for monogenic presentations, through biological plausibility. WG4 Functional investigations: creating a roadmap of genes and pathways to be prioritized for functional assessment in cell and organism models of the musculoskeletal system. WG5 Bioinformatics seeks the integration of the knowledge derived from the distinct efforts, with particular emphasis on systems biology and artificial intelligence applications. Finally, WG6 Translational outreach: makes a synopsis of the knowledge derived from the distinct efforts, allowing to prioritize factors within biological pathways, use refined disease trait definitions and/or improve study design of future investigations in a potential therapeutic context (e.g. clinical trials) for musculoskeletal diseases.

Effects of climate change on combined labour productivity and supply: an empirical, multi-model study

Although effects on labour is one of the most tangible and attributable climate impact, our quantification of these effects is insufficient and based on weak methodologies. Partly, this gap is due to the inability to resolve different impact channels, such as changes in time allocation (labour supply) and slowdown of work (labour productivity). Explicitly resolving those in a multi-model inter-comparison framework can help to improve estimates of the effects of climate change on labour effectiveness. In this empirical, multi-model study, we used a large collection of micro-survey data aggregated to subnational regions across the world to estimate new, robust global and regional temperature and wet-bulb globe temperature exposure-response functions (ERFs) for labour supply. We then assessed the uncertainty in existing labour productivity response functions and derived an augmented mean function. Finally, we combined these two dimensions of labour into a single compound metric (effective labour effects). This combined measure allowed us to estimate the effect of future climate change on both the number of hours worked and on the productivity of workers during their working hours under 1·5°C, 2·0°C, and 3·0°C of global warming. We separately analysed low-exposure (indoors or outdoors in the shade) and high-exposure (outdoor in the sun) sectors. We found differentiated empirical regional and sectoral ERF's for labour supply. Current climate conditions already negatively affect labour effectiveness, particularly in tropical countries. Future climate change will reduce global total labour in the low-exposure sectors by 18 percentage points (range -48·8 to 5·3) under a scenario of 3·0°C warming (24·8 percentage points in the high-exposure sectors). The reductions will be 25·9 percentage points (-48·8 to 2·7) in Africa, 18·6 percentage points (-33·6 to 5·3) in Asia, and 10·4 percentage points (-35·0 to 2·6) in the Americas in the low-exposure sectors. These regional effects are projected to be substantially higher for labour outdoors in full sunlight compared with indoors (or outdoors in the shade) with the average reductions in total labour projected to be 32·8 percentage points (-66·3 to 1·6) in Africa, 25·0 percentage points (-66·3 to 7·0) in Asia, and 16·7 percentage points (-45·5 to 4·4) in the Americas. Both labour supply and productivity are projected to decrease under future climate change in most parts of the world, and particularly in tropical regions. Parts of sub-Saharan Africa, south Asia, and southeast Asia are at highest risk under future warming scenarios. The heterogeneous regional response functions suggest that it is necessary to move away from one-size-fits-all response functions to investigate the climate effect on labour. Our findings imply income and distributional consequences in terms of increased inequality and poverty, especially in low-income countries, where the labour effects are projected to be high. COST (European Cooperation in Science and Technology).

Discriminating the HTM and MLRSM models in collider studies via doubly charged Higgs boson pair production and the subsequent leptonic decays * *The research has been supported by the Polish National Science Center (NCN) under grant 2015/17/N/ST2/04067, COST (European Cooperation in Science and Technology) Action CA16201 PARTICLEFACE and the research activities co-financed by the funds granted under the Research Excellence

We present a case study for the doubly charged Higgs boson pair production in and pp colliders with their subsequent decays to four charged leptons. We consider the Higgs Triplet Model ( ), which is not restricted by the custodial symmetry, and the Minimal Left-Right Symmetric Model ( ). These models include scalar triplets with different complexities of scalar potentials and, because of experimental restrictions, completely different scales of non-standard triplet vacuum expectation values. In both models, a doubly charged Higgs boson can acquire a mass of hundreds of gigaelectronvolts, which can be probed at the HL-LHC, future , and hadron colliders. We take into account a comprehensive set of constraints on the parameters of both models coming from neutrino oscillations, LHC, , and low-energy lepton flavor violating data and assume the same mass of . Our finding is that the pair production in lepton and hadron colliders is comparable in both models, though more pronounced in the . We show that the decay branching ratios can be different within both models, leading to distinguishable four-lepton signals, and that the strongest are events yielded by the . Typically, we find that the signals are one order of magnitude larger those in the . For example, the signal for 1 TeV mass results in a clearly detectable significance of for the HL-LHC and for the FCC-hh. Finally, we provide quantitative predictions for the dilepton invariant mass distributions and lepton separations, which help to identify non-standard signals.

Red europea para la investigación de la presión arterial en niños y adolescentes (COST Action CA19115)

High blood pressure is a clearly established modifiable risk factor for cardiovascular and renal disease. Although most of its adverse effects develop in adulthood, it has become clear that high BP is a lifelong problem that can manifest early in life. While few would dispute the importance of taking effective steps to identify and manage this condition in middle-aged and elderly individuals, relatively little attention has been paid to the problem of high BP in children and adolescents. Therefore, the development of actions focused on early childhood, childhood and adolescence and the investigation of the underlying causes of this epidemic are of utmost importance. There is a pressing need for comprehensive pan-European action to increase the knowledge on the prevention, diagnosis and treatment of high blood pressure in children and adolescents, the current scarcity of which impedes the development of consensus across different research fields and hinders efforts to introduce changes in clinical practice. There are some aspects that demand urgent action: the definition of hypertension, the prevalence of high BP in Europe, accurate measurement for early identification, the assessment of hypertension-mediated organ damage and the development and implementation of prevention strategies. In order to provide answers to all of these unanswered questions and challenges, a multidisciplinary network was established, maintained and funded by the European Cooperation in Science and Technology (COST) Association. COST is a funding organization for the creation of research networks known as COST Actions. In this case, the network will promote coordinated and collaborative activities on personalized preventive measures for children and adolescents across Europe.

European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.

Designed by a group of ME/CFS researchers and health professionals, the European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE) has received funding from the European Cooperation in Science and Technology (COST)—COST action 15111—from 2016 to 2020. The main goal of the Cost Action was to assess the existing knowledge and experience on health care delivery for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in European countries, and to enhance coordinated research and health care provision in this field. We report our findings and make recommendations for clinical diagnosis, health services and care for people with ME/CFS in Europe, as prepared by the group of clinicians and researchers from 22 countries and 55 European health professionals and researchers, who have been informed by people with ME/CFS.

A New Tool for Faster Construction of Marine Biotechnology Collaborative Networks

The increasing and rapid development in technologies, infrastructures, computational power, data availability and information flow has enabled rapid scientific advances. These entail transdisciplinary collaborations that maximize sharing of data and knowledge and, consequently, results, and possible technology transfer. However, in emerging scientific fields it is sometimes difficult to provide all necessary expertise within existing collaborative circles. This is especially true for marine biotechnology that directly addresses global societal challenges. This article describes the creation of a platform dedicated to facilitating the formation of short or mid-term collaborative networks in marine biotechnology. This online platform (https://www.ocean4biotech.eu/map/) enables experts (researchers and members of the marine biotechnology community in general) to have the possibility to showcase their expertise with the aim of being integrated into new collaborations/consortia on the one hand, or to use it as a search tool to complement the expertise in planned/running collaborations, on the other. The platform was created within the Ocean4Biotech (European transdisciplinary networking platform for marine biotechnology) Action, funded under the framework of the European Cooperation in Science and Technology (COST). To build the platform, an inquiry was developed to identify experts in marine biotechnology and its adjunct fields, to define their expertise, to highlight their infrastructures and facilities and to pinpoint the main bottlenecks in this field. The inquiry was open to all experts in the broad field of marine biotechnology, including non-members of the consortium. The inquiry (https://ee.kobotoolbox.org/single/UKVsBNtD) remains open for insertion of additional expertise and the resulting interactive map can be used as a display and search tool for establishing new collaborations.

The need for standardisation in life science research - an approach to excellence and trust.

Today, academic researchers benefit from the changes driven by digital technologies and the enormous growth of knowledge and data, on globalisation, enlargement of the scientific community, and the linkage between different scientific communities and the society. To fully benefit from this development, however, information needs to be shared openly and transparently. Digitalisation plays a major role here because it permeates all areas of business, science and society and is one of the key drivers for innovation and international cooperation. To address the resulting opportunities, the EU promotes the development and use of collaborative ways to produce and share knowledge and data as early as possible in the research process, but also to appropriately secure results with the European strategy for Open Science (OS). It is now widely recognised that making research results more accessible to all societal actors contributes to more effective and efficient science; it also serves as a boost for innovation in the public and private sectors. However for research data to be findable, accessible, interoperable and reusable the use of standards is essential. At the metadata level, considerable efforts in standardisation have already been made (e.g. Data Management Plan and FAIR Principle etc.), whereas in context with the raw data these fundamental efforts are still fragmented and in some cases completely missing. The CHARME consortium, funded by the European Cooperation in Science and Technology (COST) Agency, has identified needs and gaps in the field of standardisation in the life sciences and also discussed potential hurdles for implementation of standards in current practice. Here, the authors suggest four measures in response to current challenges to ensure a high quality of life science research data and their re-usability for research and innovation.

The need for standardisation in life science research - an approach to excellence and trust.

Today, academic researchers benefit from the changes driven by digital technologies and the enormous growth of knowledge and data, on globalisation, enlargement of the scientific community, and the linkage between different scientific communities and the society. To fully benefit from this development, however, information needs to be shared openly and transparently. Digitalisation plays a major role here because it permeates all areas of business, science and society and is one of the key drivers for innovation and international cooperation. To address the resulting opportunities, the EU promotes the development and use of collaborative ways to produce and share knowledge and data as early as possible in the research process, but also to appropriately secure results with the European strategy for Open Science (OS). It is now widely recognised that making research results more accessible to all societal actors contributes to more effective and efficient science; it also serves as a boost for innovation in the public and private sectors. However for research data to be findable, accessible, interoperable and reusable the use of standards is essential. At the metadata level, considerable efforts in standardisation have already been made (e.g. Data Management Plan and FAIR Principle etc.), whereas in context with the raw data these fundamental efforts are still fragmented and in some cases completely missing. The CHARME consortium, funded by the European Cooperation in Science and Technology (COST) Agency, has identified needs and gaps in the field of standardisation in the life sciences and also discussed potential hurdles for implementation of standards in current practice. Here, the authors suggest four measures in response to current challenges to ensure a high quality of life science research data and their re-usability for research and innovation.