A model for syngas production from pyrolysis oil gasification was developed, validated, and used in this work to predict the effect of operating conditions on syngas properties. The model consists of a process line that includes units for pyrolysis-oil drying, decomposition, combustion, and gasification processes. The model was validated using experimental data from the literature, showing a good agreement between the results and the reference method. Syngas potential applications were assumed, e.g., for direct use in fuel cells and fuel production. Sensitivity analysis was carried out to evaluate the impacts of gasifying agent, temperature, and the oil moisture content on syngas composition, lower heating value (LHV), and H2:CO molar ratio. For fuel cells applications, gasifying with O2 and air lead to a substantial decrease in syngas LHV. The syngas should be produced at a high temperature. The moisture content in pyrolysis-oil also should be minimized. For fuel production applications, partial O2 can be used to adjust the H2:CO molar ratio. The syngas should be produced at an appropriate temperature around 1000°C. The moisture content in pyrolysis oil should also be selected at 40%.