The main objective of this paper is to explore the success factors and barriers to digital co-creation between Higher Education Institutions (HEI) and Non-Governmental Organizations (NGO). The analysis is based on a qualitative approach, and particularly 80 semi-structured interviews with experts in digital co-creation from HEIs and NGOs from Poland, Germany, Turkey and Italy. The article identifies key success factors, including country's level of digitalization, individual's motivation to engage with digital platforms and methods, common goals, attitudes, and expectations. The study also highlights several barriers to successful digital co-creation, including variety of digital platforms, interpersonal connection, disengagement, and decreased attention spans. Among the success factors and barriers both external and internal factors were identified, all comprising a network of driving fosters and limitations to digital co-creation. Main of them include country's level of digitalization, motivation to engage with digital technology, digital literacy, incentives for engagement, shared goals and mutual understanding, variety of digital platforms, fear from losing interpersonal interactions, disengagement, and decreased attention span. The findings of this study will be of interest to HEIs, NGOs, policymakers, and other stakeholders involved in digital co-creation initiatives, providing insights on how to overcome barriers and optimize success factors to achieve effective and sustainable partnerships.