Combining a temperature variable 22-pole ion trap with a cold effusive beam of neutrals, rate coefficients k( T) have been measured for reactions of CO 2 + ions with H, H 2 and deuterated analogues. The neutral beam which is cooled in an accommodator to T ACC, penetrates the trapped ion cloud with a well-characterized velocity distribution. The temperature of the ions, T 22PT, has been set to values between 15 and 300 K. Thermalization is accelerated by using helium buffer gas. For reference, some experiments have been performed with thermal target gas. For this purpose hydrogen is leaked directly into the box surrounding the trap. While collisions of CO 2 + with H 2 lead exclusively to the protonated product HCO 2 +, collisions with H atoms form mainly HCO +. The electron transfer channel H + + CO 2 could not be detected (<20%). Equivalent studies have been performed for deuterium. The rate coefficients for reactions with atoms are rather small. Within our relative errors of less than 15%, they do not depend on the temperature of the CO 2 + ions nor on the velocity of the atoms ( k( T) lays between 4.5 and 4.7 × 10 −10 cm 3 s −1 with H as target, and 2.2 × 10 −10 cm 3 s −1 with D). For collisions with molecules, the reactivity increases significantly with falling temperature, reaching the Langevin values at 15 K. These results are reported as k = α ( T/300 K) β with α = 9.5 × 10 −10 cm 3 s −1 and β = −0.15 for H 2 and α = 4.9 × 10 −10 cm 3 s −1 and β = −0.30 for D 2.