Solid Clusters Research Articles

Cholesterol-ester prevents lipoprotein core from solidifying: Molecular dynamics simulation.

As an important part of lipid metabolism the liver produces large particles called very low density lipoproteins, filled mostly with triglyceride and cholesterol esters mixture. A large percentage of the mixture composition components has a melting point above physiological temperature. Thus solid cluster formation or phase transition could be expected. Though various single-component triglyceride systems are well researched both experimentally and by various simulation techniques, to our best knowledge, tripalmitin/cholesteryl-palmitate binary mixture was not yet studied. We study tripalmitin single component system, as well as 20%-80% and 50%-50% binary mixtures of cholesteryl-palmitate and tripalmitin using molecular dynamics approach. All systems are studied at the pressure of 1 atm and the physiological temperature of 310 K, which is below the melting points of both tripalmitin and cholesteryl-palmitate. Our results show that at the time of 1000 ns, there is still no phase transition, but there is a noticeable tendency to intermolecular organizing and early signs of clustering. We check fatty acid arrangements of tripalmitin molecules in both single component system and binary mixtures with two different percentages of cholesteryl-palmitate mixed in. Our results show that the more cholesteryl-palmitate molecules are in the mixture the smaller number of tripalmitin molecules transitions to 'a fork/chair' configuration during the same calculation time. Calculated angle distributions between fatty acid chains of tripalmitin molecules confirm that. Thus, our simulation results suggest slowing down or interfering effect of cholesteryl-palmitate on the crystallizing process of the binary mixture.

Spread Through Air Spaces: Interresponder Agreement and Comparison Between Pulmonary and General Pathologists

Spread through air spaces (STAS), an important prognostic indicator included in the 2015 World Health Organization classification, is defined as micropapillary, solid, and/or single tumor cell clusters beyond the edge of the main mass and distinct from processing artifacts. This study aimed to assess the interresponder agreement on current STAS criteria vs artifacts, identify discrepancies, and compare responses between pulmonary and general pathologists. A multiple-choice online questionnaire illustrating multiple criteria for STAS vs artifacts was available internationally for 6 days to Pulmonary Pathology Society members, thoracic pathology course attendees, and International Association for the Study of Lung Cancer pathology committee members. Additional 4 questions gathered demographic and practice setting information. One hundred thirty-six unique responses were analyzed. The majority were from North America and Europe (42.6% and 30.2%), practicing pulmonary pathology (70.6%) in academia (64.7%), and with >20 years of experience (31.6%). Excluding trainees, the greatest overall agreement was in defining solid and micropapillary tumor clusters of STAS located ≥3 alveolar spaces from the main tumor edge (91.5%) and recognizing strips of ciliated cells as artifacts (97.7%). Lesser agreement on STAS was evident when tumor cell clusters were immediately adjacent to the tumor edge, a single tumor cell cluster was present at the tissue edge, tumor cell clusters were jagged edged, or tumor cell clusters were admixed with ciliated cell strips (artifacts). There was no significant difference in agreements on STAS for multiple criteria between pulmonary and general pathologists. Significant interresponder agreement on STAS vs artifacts was achieved only for a few criteria. To improve the reproducibility of STAS vs artifacts, areas of lesser agreement require further clarification.

Extension of the lattice-based aggregation-volume-bias Monte Carlo approach to molecular crystals: Quantitative calculations on the thermodynamic stability of the urea polymorphs.

Motivated by the recent success in using a latticed-based version of the aggregation-volume-bias Monte Carlo method to determine the thermodynamic stabilities of both bcc and fcc clusters formed by Lennard-Jones particles, this approach is extended to the calculation of the nucleation-free energies of solid clusters formed by urea at 300K in two different polymorphs, i.e., form I and form IV. In addition to the lattice confinement, the constraint on the molecular orientation was found necessary to ensure that the clusters sampled in these simulations are in the corresponding form. A model that can reproduce the experimental properties such as density and lattice parameters of form I at ambient conditions is used in this study. From the size dependencies of the free energies obtained for a finite set of clusters studied, the free energies of clusters at other sizes, including an infinitely large cluster, were extrapolated. At the infinite size, equivalent to a bulk solid, form I was found to be more stable than form IV, which agrees with the experimental results. In addition, form I was found to be thermodynamically stable throughout the entire cluster size range investigated here, which contradicts the previous finding that small form I clusters are unstable from the crystal nucleation simulation studies.

HISTOMORPHOLGICAL STUDY OF THE PARATHYROID GLAND OF ONE-HUMPED CAMEL (CAMELUS ‎DROMEDARIUM)‎

Parathyroid gland of ten adult one-humped came] has been collected from the slaughter house. Glands have been fixed sectioned and stained by several procedures. The gland measured 1.2 cm in length, 0.4 cm in width and 0.25 cm thick. It differs in position from left to right side due to displacement of thyroid gland. The gland consisted of aggregate of cells arranged as solid masses, clusters, cords or strands. The parenchyma of the gland appeared with different cell density. Four cell type has been distinguished, viz., light as well as dark chief cells, oxyphils and syncytial cells.

An approach to solving the effect of background in fluidized bed on electromagnetic tomography

As a non-invasive measurement technique, electromagnetic tomography (EMT) system based on tunneling magneto resistance (TMR) can detect the distribution of medium in the gas–liquid–solid fluidized bed by the difference of permeability. The distribution of medium in the three-phase fluidized bed is not uniform, and the solid clusters and bubble clusters are formed in the background of the gas–liquid–solid mixture. Since the effect of the background in the pipe of the fluidized bed on the boundary measurement data of the TMR-EMT system is much greater, it is difficult to detect solid clusters and bubble clusters when the image is reconstructed directly using the boundary measurement data. In order to improve the detection of clusters by the TMR-EMT system, a method to weaken the effect of the background is proposed. The equivalent magnetic circuit model is used to estimate the background permeability. Then the magnetic dipole theory and demagnetization effect theory are utilized to establish a simple background compensation model based on the estimated background permeability. Using the compensation model, the effect of the background is weakened from the boundary measurement data and the cluster distribution information is highlighted. Simulation and experimental results demonstrate the effectiveness of the proposed method.

Liquid-like clusters in glassy solids as a unique state of matter: Dissipative but non-diffusive

The field of glassy studies has long speculated about the existence of liquid-like regions within solid amorphous states. However, limited evidence from indirect investigations has left the question of their presence unanswered. In this study, we propose a computational approach to analyze dissipation characteristics at the atomic level. Our findings reveal the actual existence of localized liquid-like dissipation clusters in the glassy state, demonstrating a damping factor similar to liquids and a vanishing shear modulus. Surprisingly, these clusters are only observed at low temperatures and do not involve diffusive motions, unlike typical liquids. This unique state of condensed matter is dissipative but non-diffusive. In metallic glasses, we show that these clusters are responsible for the recently discovered β' relaxation. Our results provide a solid basis for the longstanding concept of liquid-like region in glassy materials and provide a new perspective on establishing structure-property correlations.

Small luminescent silver clusters stabilized in porous crystalline solids.

Subnanometric or small metal clusters (SMCs) have been extensively researched due to their unique electronic, optical, catalytic, and magnetic properties, which differ from those of bulk samples. Among the SMCs, silver (Ag) clusters have received significant interest due to their affordability and unique luminescent properties. Currently, two major approaches, gas-phase and liquid-phase synthesis, have been employed to obtain Ag clusters with precise control of size and structure. More recently, attention has been directed toward the utilization of porous crystalline solids such as metal-organic frameworks (MOFs), zeolites, and porous ionic crystals (PICs) to synthesize and stabilize Ag clusters. In this review, we aim to provide a comprehensive overview of the synthesis, structures, and luminescent properties of Ag clusters in porous crystalline solids.

Cu/CeO2 catalysts for reverse water gas shift reactions: the effect of the preparation method.

The reverse water gas shift reaction is one of the most prospective CO2 utilization approaches. Cu has excellent selectivity for CO and CeO2 is rich in surface oxygen vacancies for CO2 activation. These unique properties are often used to develop efficient Cu/CeO2 catalysts in RWGS. In this paper, Cu/CeO2 is prepared by plasma-induced micro-combustion. The effect of the subsequent calcination after micro-combustion on the structure and catalytic property is systemically studied. Because of the mild temperature of micro-combustion, highly dispersed Cu species load on the surface of CeO2 for the catalyst without calcination (Cu/CeO2-mc). During calcination, the highly dispersed Cu species form two kinds of species, Cu-Ce solid solution structure and small CuO clusters (Cu/CeO2-mcc). The Cu-Ce solid solution effectively enhances the generation of oxygen vacancies, which improves the adsorption and activation of CO2. The catalytic performance of Cu/CeO2-mcc thereby is superior to Cu/CeO2-mc in RWGS. In situ diffuse reflectance infrared fourier transform spectroscopy analysis demonstrates that the formate pathway is the main mechanism of RWGS. CO2 adsorbed on the surface of Cu/CeO2-mcc mainly forms bidentate species. While monodentate generates on the surface of Cu/CeO2-mc. And decomposes to CO easier than , thus Cu/CeO2-mcc exhibits excellent catalytic properties. This work provides a new approach for structural modulation of catalysts with excellent catalytic performance in RWGS.

(Invited) Molecular Imaging of the Local Solvation, Nucleation and Growth Processes at Electrode-Electrolyte Interfaces

Electrochemical energy storage is a complex process that requires the synergistic participation of electrodes, electrolytes, and separators in the system. However, the key energy storage functions usually depend critically on the electrode-electrolyte interfaces, which include both the electrode surface and the electrical double layers (EDLs). Here I will discuss our efforts on developing and using electrochemical 3D atomic force microscopy (EC-3D-AFM) to simultaneously image the electrode and EDLs under operando conditions, with atomic-scale resolution. We study the interface between graphite electrode and various types of electrolytes. We observe rich EDL reconfiguration effects at different electrode potentials, which we find to be directly responsible for the capacitive charge storage functions. As the electrode potential goes beyond the electrochemical stability window of the electrolyte, we observe nucleation and growth processes where the EDLs and the deposited solid clusters exhibit intertwined structures. Such initial stage of electrode processes is likely connected to the long-term cycling behaviors of batteries.

Primary pulmonary NUT carcinoma: a clinicopathological analysis of seven cases

Objective: To investigate the clinicopathological characteristics of primary pulmonary NUT carcinoma. Methods: A total of 7 cases of primary pulmonary NUT carcinoma were collected from Fujian Provincial Hospital (n=5), Fuzhou Taijiang Hospital (n=1) and Binzhou City People's Hospital of Shandong Province (n=1) from January 2021 to April 2023. The clinical, histopathological, and immunohistochemical features were analyzed, and NUT rearrangement were detected by fluorescence in situ hybridization (FISH) with break-apart probes. Results: Seven cases were all male with age ranging from 32 to 73 years. The main clinical manifestations were cough, expectoration and chest tightness. Microscopically, NUT carcinoma was composed of monotonous proliferation of primitive-appearing small-to-medium round cells, with few eosinophilic cytoplasm, arranged in solid sheets, nests or clusters. Abrupt keratinization was typically observed in 4 cases (4/7), with high mitotic activities and necrosis. Immunohistochemistry (IHC) showed that the tumors were positive for NUT (7/7), CK7 (4/4), CK5/6 (5/6), p40 (6/7). Ki-67 index were 30%-80%. NUT gene segregation (7/7) was detected by FISH break probes. Conclusions: Primary pulmonary NUT carcinoma is rare and highly malignant. Diagnosis depends on histopathology and IHC, with molecular detection as an adjunct for diagnosis. Pathologists should be aware of the clinicopathological characteristics to avoid misdiagnosis.

Regional clustering and waves patterns due to COVID-19 by the index virus and the lambda/gamma, and delta/omicron SARS-CoV-2 variants in Peru.

Coronavirus disease 2019 (COVID-19) impact varies substantially due to various factors, so it is critical to characterize its main differences to inform decision-makers about where to focus their interventions and differentiate mitigation strategies. Up to this date, little is known about the patterns and regional clustering of COVID-19 waves worldwide. We assessed the patterns and regional clustering of COVID-19 waves in Peru by using the weekly mortality rates for each of the 25 regions as an outcome of interest. We obtained the death counts from the National Informatics System of Deaths and population estimates from the National Registry of Identification and Civil Status. In addition, we characterized each wave according to its duration, peak, and mortality rates by age group and gender. Additionally, we used polynomial regression models to compare them graphically and performed a cluster analysis to identify regional patterns. We estimated the average mortality rate at the first, second, and third waves at 13.01, 14.12, and 9.82 per 100,000 inhabitants, respectively, with higher mortality rates among elders and men. The patterns of each wave varied substantially in terms of duration, peak, impact, and wave shapes. Based on our clustering analysis, during the first wave caused by the index virus, the 25 regions of Peru presented six different wave patterns. However, the regions were clustered in two different wave patterns during the second and third, caused by alpha/lambda/delta and omicron. The propagation of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) variants behaved in Peru with varying wave patterns and regional clustering. During the COVID-19 pandemic, the weekly mortality rates followed different spatiotemporal patterns with solid clustering, which might help project the impact of future waves of COVID-19.

Embryonic development of the chick pineal gland throughout the incubation periods.

Birds have a very different pineal gland structure morphologically and cytologically. The structure of the organ shows significant changes during the incubation periods. This study, which follows the embryological development of the pineal gland and makes histomorphometric measurements of the cellular elements that make up the gland parenchyma, is a current reference for studies in these areas. These brains were taken from 24 Babcock White Leghorn chick embryos on the 10th, 13th, 16th and 21st days of incubation. At 10th embryonic day, the pineal recess was in the structure of an elongated pineal canal. Solid rosette-shaped cell clusters were transforming into round vesicles with a small lumen. These vesicles had developed into larger, oval-shaped follicles with a well-defined central lumen. On 13th day, it was observed that the number and development of follicles increased considerably. The pineal gland showed a follicular-solid structure in 16th day embryos. While the mean follicle diameter was determined as 123.46 ± 13.28 μm on the 10th embryonic day, the highest value was measured as 187.62 ± 7.37 μm on the hatching day (p < 0.05). While the mean follicle area had the lowest value in the 10th day embryos, it was determined that this value gradually increased compared to the advancing embryonic days (p < 0.05). As conclusion, it is thought that this study provides new data to the literature about pineal gland development by monitoring the histological and histomorphometric developments of chick pineal gland in different incubation periods.

Catalytic Sequences and Kinetic Requirements for C–O Bond Scission and Formation in Methanol and Trioxane on Solid Polyoxometalate Clusters

Catalytic Sequences and Kinetic Requirements for C–O Bond Scission and Formation in Methanol and Trioxane on Solid Polyoxometalate Clusters

THU525 Atypical Presentation Of Parathyroid Carcinoma In The Lungs

Abstract Disclosure: J.N. Jacinto: None. O. Reyes: None. M. Cating-Cabral: None. R. Santiago: None. J. Andal: None. A 66-year-old female with a history of parathyroid adenoma underwent partial parathyroidectomy and thyroidectomy of the right lobe in 2006. She has the following comorbidities: pre-diabetes, hypertension, multiple liver cysts, medullary nephrocalcinosis and nephrolithiasis, ureterolithiasis and uterine intramural myoma. She also has a strong familial disposition of endocrine tumors. During the last quarter of 2018, parathyroid hormone and calcium levels were elevated and parathyroid imaging revealed an adenoma on the posteromedial aspect of the left thyroid lobe. Removal of the adenoma was offered but insisted on medical treatment. In 2022, she was admitted for subarachnoid hemorrhage due to fall. There was an incidental finding of a lung mass with minimal pleural effusion on the right lung lobe. PET-scan revealed five FDG-avid nodules (SUV up to 9.6) with the largest in the right middle lobe measuring 2 x 2 x 2 cm. Percutaneous needle biopsy was performed which showed a tumor with fairly uniform cells in organoid nests and solid clusters. By immunohistochemistry (IHC), the tumor cells were diffusely and strongly positive for CK and GATA-3; focally positive for chromogranin and synaptophysin; and negative for TTF-1, Pax-8, and S100. This was signed out as an epithelial tumor with neuroendocrine features; the differential diagnosis includes pulmonary neuroendocrine tumor versus metastasis from the prior parathyroid lesion. She subsequently underwent completion thyroidectomy and video-assisted thoracoscopic surgery. The lung wedge resections both showed tumors with similar morphology and IHC staining pattern as the biopsy. Additional stains were also performed to rule out other entities, which were all negative (CK7, CK20, CD56, mammaglobin, GCDFP-15, TTF-1, S100, ER, Pax-8, HSA, and SALL-4). The Ki-67 proliferation index was 17.26%. Because the overall findings were not definitive, comprehensive genomic profiling by next generation sequencing (NGS) was recommended and subsequently performed. NGS showed gene alteration in CDC73, with a variant allele frequency of 50%; this finding has been documented in parathyroid carcinoma. Pre-operative parathyroid hormone levels remained unchanged (408 to 397 pg/ml) despite surgery. Currently, there is no available targeted therapy to address her genomic alteration. Hyperparathyroidism-jaw tumor syndrome was entertained. The multidisciplinary team advised en-bloc resection of the lung tumor and additional gene testing for family members. She opted for palliative care and is on cinacalcet for her hyperparathyroidism. Presentation: Thursday, June 15, 2023

Direct evidence on the crossover from BCC to FCC stability: A lattice-based aggregation-volume-bias Monte Carlo approach to polymorphism.

A lattice-based version of the aggregation-volume-bias Monte Carlo method that was introduced recently has allowed for the extension of the calculation of the nucleation free energies from liquid clusters to solid clusters. Here, it was used to calculate the nucleation free energies of both bcc and fcc clusters formed by Lennard-Jones particles. Under the simulation conditions considered in this study, a cross-over of the thermodynamic stability from the bcc to the fcc structure was observed directly from the free energy results. In addition, the free energies obtained for both types of clusters were used to extrapolate bulk phase information, including chemical potential and surface tension, which revealed that bcc clusters are favored due to the lower surface tension. These results corroborate a recent classical density functional theory study. This work also demonstrates that this approach can be used to predict the entire thermodynamic landscape (i.e., free energies for clusters of different structures and sizes, including an infinitely large cluster, which is the bulk phase), which is important to answer fundamental questions related to crystallization such as the origin of polymorphism.

Diaryl(fluorinated)-mercury species as potential precursors of triaryl(fluorinated)-gallium to be used in the synthesis of cyclometallated Ga compounds and unexpected formation of aryl-Ga clusters

The first goal of this work was to explore the feasibility of diaryl-mercury species as the synthetic precursors of triaryl-gallium species GaAr*3 (where Ar*= pH, 4; Ar*= 3,5-difluorophenyl, 5; and Ar*= 3,5-trifluoromethylphenyl, 6). Expecting that 4–6 behave as Lewis acids of different strength, the second purpose was to use them for the synthesis of either rollover or classic cyclometallated Ga compounds. Three analogous diaryl-mercury HgAr*2 species, 1–3, were successfully synthesized. The structures of compounds 2 and 3 were confirmed by gas chromatography - mass spectrometry experiments. Additionally, compound 3 was analyzed through X-ray diffraction; in the crystal structure obtained, π-stacking interactions were observed. The only Ga compound synthesized was GaPh3, 4, because the presence of fluorine-containing groups in meta-position caused sublimation of the respective mercury diaryl compounds, impeding their reaction with gallium. The attempts toward the synthesis of the rollover or classic cyclometallated compounds in the reaction of 4 with bipyridine-, pyrazole- or benzo-imidazole- type ligands have failed. On the other hand, under the experimental conditions applied, water traces favored formation of the solid aryl-Ga cluster containing twelve Ga atoms [Ga12], whereas the above-mentioned ligands were quantitatively recovered in the solution. The identity of aryl-gallium cluster was confirmed by electrospray ionization - high resolution mass spectrometry. Although Ga cluster was not expected, it is considered an important finding of this work, owing to the variety of possible applications and still limited data available on the synthesis and structural characterization of such compounds.

Understanding the Stability of an Unprecedented Si-Be Bond within Quantum Confinement.

As of today, the Si-Be bond remains underexplored in the literature, and therefore its anomalous behavior continues to be an unsolved puzzle to date. Therefore, the present study aims at evaluating the integrity of an unprecedented Si-Be bond within quantum confinement. To accomplish this, first-principles-based calculation are performed on Be-doped silicon clusters with atomic sizes 6, 7, and 10. Silicon clusters are sequentially doped with one, two, and three Be atoms, and their thermal response is registered in the temperature range of 200-1500 K, which discloses several research findings. During the course of the simulations, the clusters face various thermal events such as solid cluster phase, rapid structural metamorphosis, and fragmentation. Si-Be nanoalloy clusters are noted to be thermally stable at lower temperatures (200-700 K); however, they begins to disintegrate earlier at a temperature as low as 800 K. This lower stability is attributed to the weak nature of Si and Be heteroatomic interactions, which is corroborated from the structural and electronic property analysis of the doped clusters. In addition to this, the performance of Be-doped clusters at finite temperatures is also compared with the thermal response of two other popular systems, viz., C- and B-doped silicon clusters.

Conductivity of Multicomponent Alloy under Solid Solution Short-Range Order Cluster Model.

The characteristic of short-range order of multicomponent alloy solid solution promotes the necessity of deeply studying and establishing the microatomic structure behind the alloy components as well as the association with the corresponding macro-physical properties, so as to guide the development of high-performance multicomponent alloys through effective composition theory design. In this research, the popular Inconel 718 nickel-base superalloy with wide application and development is taken as an example. On the one hand, on the basis of the method of "the nearest neighbor cluster plus connecting atom" qualitatively proposed by predecessors to characterize the short-range order atomic arrangement structure of multicomponent alloy solid solution due to the interaction between electrons of atoms introduced into solid solution, Friedel oscillation potential function is generated and associated with the radial density of the corresponding atomic arrangement. On the other hand, according to the construction method of the nearest neighbor cluster in alloy phase that proposes the definition of using the maximum density of atomic radial arrangement to meet the minimum principle of energy stacking, the creatively accurate expression on the spatial structure of short-range order cluster of multicomponent alloy solid solution is achieved in a quantitative manner. Furthermore, with the impact of spatial distribution content of atoms in multicomponent alloy on the external current electron scattering rate (i.e., resistivity), the accurate analysis on the conductivity of multicomponent alloy by using the short-range order cluster model of alloy solid solution is realized through the weighting idea of atomic content of each element to the resistivity (the prediction rate is within 5%).

Detection of Calreticulin as a Candidate Prognostic Biomarker in Invasive Breast Carcinoma from a Biological Scaffold-Based 3D Co-culture System

Introduction: Breast cancer is the most common cancer in women and the world’s second leading cause of death in women, after lung cancer. Calreticulin (CRT), an endoplasmic reticulum (ER) multipurpose protein, has been proposed as a potential biomarker for breast cancer. However, reports on the correlation between CRT expression and cell invasiveness in breast cancer micro-tissues are scarce. Thus, in the current study, we analyzed the potential correlation between CRT and invasiveness of breast cancer in a biological scaffold-based 3D co-culture system. Methods: MCF7, MDA-MB-231 and MCF-10A breast cell lines were co-cultured in a 3-dimensional (3D) system with MRC-5 lung fibroblast cell line in the cell density ratio of 3:1. Thereafter, calreticulin gene and protein expression levels were determined based on quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and immunohistochemistry, respectively. Moreover, via RT-qPCR analysis, the gene expression levels of calreticulin-related candidate metastasis genes in breast cancer micro-tissues were carried out. Results: The results showed occasional foci of lumen-like morphology in the non-cancerous breast micro-tissues and the formation of solid clusters for breast cancer micro-tissues. Moreover, immunohistochemistry results revealed protein expression of calreticulin in non-cancerous and cancerous breast micro-tissues with cytoplasmic and nucleic acid localizations. It was found that PCMT1 and ER-α genes were significantly downregulated (p &lt; 0.01) in invasive breast cancer micro-tissues. Conclusion: This study suggests that CRT and CRT-related candidate metastasis genes may potentially serve as prognostic biomarkers in invasive breast carcinoma.

A PERMEABILITY HYSTERESIS MODEL FOR FRACTAL POROUS MEDIA BASED ON ELASTIC-STRUCTURAL DEFORMATION OF CAPILLARY CROSS SECTION

Permeability hysteresis under cyclic pressure loading and unloading has received a lot of attention in both science and engineering. But most of the existing model is only for a one-time pressure cycle. Therefore, a permeability hysteresis model is established based on the theory of elastic-structural deformation of capillary cross section and the fractal theory of porous media. Both the triangular and quadrilateral structures are considered. The stress sensitivity of structural deformation decreases with the increase in the cycle. The porosity hysteresis can also be predicted by the proposed model. Compared with experimental data with different permeability hysteresis, the prediction of the proposed model is consistent with the experimental results. Compared with other models, the proposed model has a smaller average error and a better agreement with experimental data. The proposed model can predict the permeability hysteresis under not only a one-time pressure cycle like the existing model but also multiple pressure cycles. The influence of parameters shows that the decrease in Young’s modulus and Poisson’s ratio of the solid cluster increases the permeability stress sensitivity but does not influence the permeability hysteresis. The increase in the proportion of quadrilateral structure and stress sensitivity of structural deformation increases the permeability hysteresis and stress sensitivity at the same time, while the capillary fractal dimension, tortuosity fractal dimension, and the decay rate of stress sensitivity of structural deformation during the cycles show the opposite. The proposed model has a significant meaning in underground resource mining and the study of permeability hysteresis mechanism.