Future high-resolution microwave background measurements hold the promise of detectinggalaxy clusters throughout our Hubble volume through their Sunyaev–Zel’dovich (SZ)signature, down to a given limiting flux. The number density of galaxy clusters is highlysensitive to cluster mass through fluctuations in the matter power spectrum,as well as redshift through the comoving volume and the growth factor. Thissensitivity in principle allows tight constraints on such quantities as the equation ofstate of dark energy and the neutrino mass. We evaluate the ability of futurecluster surveys to measure these quantities when combined with Planck-like CMBdata. Using a simple effective model for uncertainties in the cluster mass–SZ fluxrelation, we evaluate systematic shifts in cosmological constraints from cluster SZsurveys. We find that a systematic bias of 10% in cluster mass measurements cangive rise to shifts in cosmological parameter estimates at levels larger than the1σ statistical errors. Systematic errors are unlikely to be detected from the massand redshift dependence of cluster number counts alone; increasing survey sizehas only a marginal effect. Implications for upcoming experiments are discussed.