Clozapine-induced Myocarditis Research Articles

P.3.c.036 Clinical efficacy, body weight change and cardiac safety of zotepine in schizophrenic patients

The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler’s Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of the 2011 publications on adverse reactions to antipsychotic drugs covers amisulpride, aripiprazole, chlorpromazine, chlorprothixene, clozapine, fluphenazine, haloperidol, iloperidone, loxapine, olanzapine, paliperidone, perphenazine, pimozide, prochlorperazine, quetiapine, risperidone, sertindole, sulpiride, thioridazine, ziprasidone, zotepine, and zuclopenthixol, and includes two special reviews on thromboembolism associated with antipsychotic drugs and on clozapine-induced myocarditis and pericarditis.

Clozapine-Induced Hypersensitivity Myocarditis

A rare, but frequently fatal, side effect of the antipsychotic drug clozapine is myocarditis. We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first time through endomyocardial biopsy and was successfully treated with corticosteroids. Histologic diagnosis was based on the evidence of eosinophilic infiltration of the endomyocardium and eosinophil degranulation. Endomyocardial biopsy was performed in order to establish or exclude a clear-cut relationship between cardiac dysfunction and clozapine, and was crucial to establish a correct diagnosis and appropriate treatment. Clozapine withdrawal and targeted 8-day, low-dose corticosteroid therapy resolved the symptoms and restored cardiac function.

Alterations of glucose metabolism during treatment with clozapine versus amisulpride

The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler’s Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of the 2011 publications on adverse reactions to antipsychotic drugs covers amisulpride, aripiprazole, chlorpromazine, chlorprothixene, clozapine, fluphenazine, haloperidol, iloperidone, loxapine, olanzapine, paliperidone, perphenazine, pimozide, prochlorperazine, quetiapine, risperidone, sertindole, sulpiride, thioridazine, ziprasidone, zotepine, and zuclopenthixol, and includes two special reviews on thromboembolism associated with antipsychotic drugs and on clozapine-induced myocarditis and pericarditis.