The integration of industry and education in the era of big data is not only a policy requirement, but also in line with the development trend of technological change. However, from the perspective of colleges, teachers and enterprises, there are many practical difficulties in the integration of industry and education in the current big data era: the level of informatization construction of vocational colleges needs to be improved; the informatization capabilities of teachers cannot meet the development needs of industry and education integration; enterprises there is insufficient motivation to promote the integration of industry and education. This article uses research methods of literature and questionnaire survey, based on big data thinking: use user thinking, centering on the needs of industries and enterprises; use cross-border thinking to promote cross-border integration of talent training; use social thinking to reshape the relationship between industry and education; use iterative thinking to constantly innovate; use platform thinking to build a cloud service platform for integration of industry and education.