Hospital information systems (HISs) accelerate hospital-related operations and reduce errors. However, previous HISs lack flexibility and scalability, consequently limiting the development of medical institutions. The characteristics of cloud computing services are crucial in helping hospitals overcome such a deepening dilemma. Nonetheless, only few medical institutions has begun partial utilisation of cloud computing services. Therefore, this research explores the resistance factors encountered during the organisation innovation process using the innovation resistance theory. Furthermore, the developmental barriers of an organisation are summarised into the following seven categories: the expertise barriers, operational barriers, resource barriers, rules barriers, market entry barriers, data security barriers, and barriers of cloud service quality. Utilisation of interpretive structural modelling also facilitates further exploration of the interaction structures among the barriers of organisational innovations. Based on the correlation and causation of the barriers, policy recommendations are proposed for the allocation of resources.