Cloud Computing Tools Research Articles

Cloud computing and big data: Technologies and applications

Cloud computing and big data: Technologies and applications

G-DOC Plus - an integrative bioinformatics platform for precision medicine.

BackgroundG-DOC Plus is a data integration and bioinformatics platform that uses cloud computing and other advanced computational tools to handle a variety of biomedical BIG DATA including gene expression arrays, NGS and medical images so that they can be analyzed in the full context of other omics and clinical information.ResultsG-DOC Plus currently holds data from over 10,000 patients selected from private and public resources including Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and the recently added datasets from REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT), caArray studies of lung and colon cancer, ImmPort and the 1000 genomes data sets. The system allows researchers to explore clinical-omic data one sample at a time, as a cohort of samples; or at the level of population, providing the user with a comprehensive view of the data.G-DOC Plus tools have been leveraged in cancer and non-cancer studies for hypothesis generation and validation; biomarker discovery and multi-omics analysis, to explore somatic mutations and cancer MRI images; as well as for training and graduate education in bioinformatics, data and computational sciences. Several of these use cases are described in this paper to demonstrate its multifaceted usability.ConclusionG-DOC Plus can be used to support a variety of user groups in multiple domains to enable hypothesis generation for precision medicine research. The long-term vision of G-DOC Plus is to extend this translational bioinformatics platform to stay current with emerging omics technologies and analysis methods to continue supporting novel hypothesis generation, analysis and validation for integrative biomedical research. By integrating several aspects of the disease and exposing various data elements, such as outpatient lab workup, pathology, radiology, current treatments, molecular signatures and expected outcomes over a web interface, G-DOC Plus will continue to strengthen precision medicine research. G-DOC Plus is available at: https://gdoc.georgetown.edu.Electronic supplementary materialThe online version of this article (doi:10.1186/s12859-016-1010-0) contains supplementary material, which is available to authorized users.

Perception of cloud computing in developing countries

Purpose – The purpose of this paper is to explore the perceptions of librarians engaged in Indian academic libraries towards cloud computing. Design/methodology/approach – A structured questionnaire was used to collect responses from the library professionals engaged in Indian academic libraries. Overall, 339 respondents participated in the survey. Descriptive survey method was used in the study. Findings – The findings of the study reveal that library professionals are using cloud-computing tools in their daily works. They want to adopt cloud computing in the libraries to improve library services and avoid redundancy of works. Ubiquitous availability, economy and the various service layers are the core drivers of its adoption in the libraries. The respondents showed their concern over security and data privacy in cloud. Practical implications – The study establishes the fact that the benefits of cloud computing are inadequate to convince the libraries to migrate from the traditional computing paradigm to the cloud. Technological advancement may not transform the cloud into a mainstream technology. To motivate the expansion of cloud computing adoption, emphasis has to be laid upon collaboration between the cloud service providers supplemented by solid cloud legislations which need to be worked out. Originality/value – The paper provides the perceptions of library professionals in response to the adoption of cloud computing.

Reframing E-Government Development Indices with Respect to New Trends in ICT

Abstract E-government readiness is an important indicator of the quality of a country’s technological and telecommunication infrastructure and the ability of its citizens, businesses and governments to adopt, use and benefit from modern technologies. To measure and compare selected countries, a lot of benchmarking and ranking indices have been introduced since the beginning of the century. With the increasing importance of trends such as cloud computing, open (big) data, participation tools or social media, new indicators and approaches need to be introduced in the measuring of the e-government development, and the existing indices should to be updated, redefined and restructured. Therefore, this article explores the structure of the existing e-government development indices to show the main indicators and trends. Then, it proposes and implements a new framework to evaluate e-government development using these new trends in ICT. It also examines and compares a basic background on the e-government development, benefits and risks of cloud computing, open (big) data and participation tools in the public sector. Based on the newly proposed framework, the e-government development index is calculated for each EU Member State to clearly identify the indicators to have an influence on the e-government development. In the last part, these results are compared to the already existing indices to validate the conformity of the rank methods using Kendall rank correlation coefficient.

Abstract B1-44: G-DOC Plus: A cloud based next-generation systems medicine platform for precision medicine

Abstract Systems medicine leverages complex computational tools and high dimensional data offering the potential for effective individualized diagnosis, prognosis and treatment options. Our flagship web platform, the Georgetown Database of Cancer (G-DOC), was deployed with the goal of enabling translational research by integrating patient characteristics and clinical outcome data with a variety of high-throughput research data in a unified environment. With the goal of improving health outcomes through genomics research, we present G-DOC Plus, our enhanced web platform offering precision medicine, translational research and population genetics workflows. This enhanced platform takes advantage of cloud computing to handle next generation sequencing (NGS) data so that they can be analyzed in the full context of other omics and clinical information. G-DOC Plus uses cloud computing and other advanced computational tools to enable analysis of NGS and medical images in the full context of other omics and clinical information. It allows translational science researchers to explore data one sample at a time, as a sub-cohort of samples; or as a population as a whole, providing the user with a comprehensive view of the data. G-DOC Plus tools have been leveraged in cancer to support detection of prognostic markers for relapse in colorectal cancer samples, and to detect key metabolites related to disease severity; hypothesis generation; biomarker detection and multi-omic analysis, in-silico and population genetics analysis; and to explore somatic mutation and breast cancer MRI images. The long-term vision of G-DOC Plus is to extend this systems medicine platform to hospital networks to provide clinical decision support using multi-omics and relevant clinical information to support personalized patient care. G-DOC Plus was released in October 2014, and is available at: https://gdoc.georgetown.edu. Citation Format: Krithika Bhuvaneshwar, Anas Belouali, Varun Singh, Robert M. Johnson, Lei Song, Adil Alaoui, Michael Harris, Yuriy Gusev, Robert Clarke, Subha Madhavan. G-DOC Plus: A cloud based next-generation systems medicine platform for precision medicine. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B1-44.

The American conference on pharmacometrics 2014 (ACoP5)

Welcome to ACoP5 in Las Vegas. ACoP represents the annual meeting of the International Society of Pharmacometrics (ISoP), which continues to grow with members from over 30 countries and 5 continents. The mission of ISoP is to advance and promote the scientific discipline of pharmacometrics and broaden its impact. The outstanding programming at ACoP5 reflects this mission and features innovative methods and strategies for integrating pharmacometrics and advancing its role in making critical decisions in drug discovery, development, and utilization. The structure and format of ACoP continues to evolve. This year we have added a formal awards session before the opening reception, along with an inspiring Keynote address from Dr. Leslie Benet (UCSF). We have continued to feature concurrent sessions to provide high quality content for a broad range of topics so that you can choose sessions that address your specific interests. Also, based on the overwhelming positive responses to our free ‘‘tutorials’’ section, we have increased the number of tutorials offered this year, providing an excellent opportunity to learn new skills related to model simplification techniques, cloud computing, or pharmacometrics research tools in R. Our society is also interested in expanding its scope into systems pharmacology, and our state-of-the-art lecture from Dr. Bernhard Palsson (UCSD) will highlight the latest approaches to predictive biology using genome-scale models. The scientific program of ACoP5 is exceptional, and the symposia, special lectures, open forum, and tutorials address critical needs in theoretical and applied pharmacometrics and systems pharmacology. Sessions include leaders in these fields with insights into approaches for the effective integration of new techniques in translational pharmaceutical research. The record number of posters to be presented at ACoP5 also showcase the excellence and diversity of scientific research in our field. On behalf of the ISoP membership, we acknowledge and thank Vikram Sinha (Programming Committee Chair), Jing Liu (Abstract Committee Chair), and all the members of the ACoP5 planning team, for their outstanding efforts in organizing this exciting conference. In addition to the main ACoP5 conference, we hope that you will take advantage of the excellent preand postmeeting educational workshops. ACoP5 will provide the opportunity for you to discover new innovative approaches and powerful applications of pharmacometrics, and to make the most of the many networking opportunities provided during ACoP5 to meet old friends and make new acquaintances with a shared passion for pharmacometrics. Enjoy ACoP5!

Platformation: Cloud Computing Tools at the Service of Social Change

IntroductionThere are now more devices connected to the Internet than there are people on the planet. By 2020, CISCO predicts that 50 billion devices will be connected. While some may feel overwhelmed by this proliferation of connectedness, others see opportunity. We envision connectivity as a driver of social change.The implications of connectivity on business have been

Platformation: Cloud Computing Tools at the Service of Social Change

IntroductionThere are now more devices connected to the Internet than there are people on the planet. By 2020, CISCO predicts that 50 billion devices will be connected. While some may feel overwhelmed by this proliferation of connectedness, others see opportunity. We envision connectivity as a driver of social change.The implications of connectivity on business have been

Cloud Computing, Big Data, and Open Access at EDUCAUSE 2009

Soon after first major snowstorm of season, 3,800 delegates to EDUCAUSE 2009 were greeted in Denver by warm temperatures and blue skies over distant front range from November 3-6, 2009. With a national climate of shrinking IT budgets and increasing needs at institutions of higher education, many sessions and conversations centered around taking advantage of economies represented by new technologies such as cloud computing and distributed communication tools. Higher education IT professionals gathered at Colorado Convention Center and simultaneously online to uncover the best thinking in higher education.