Due to the needs of today's society, there must be a particular group of people working in a high-temperature thermal radiation environment. High-temperature environments can quickly cause significant harm to the human body, while thermal protective clothing can effectively reduce the harm to the human body caused by high temperatures. We can solve this problem by building a model. Set up a multi-layer protective clothing for heat conduction formula under the temperature variation of heat conduction model of the MATLAB to map the temperature with time, 3 d surface figure, the variation of the temperature distribution can lead the Excel data tables, and processing the data in the table data, using MATLAB software to curve fitting, the fitting curve of time and skin temperature. At the same time, on the optimal thickness of protective clothing, can be based on the initial conditions and boundary conditions, construct the objective function, and use the improved particle swarm algorithm for solving, specific calculation will difference algorithm as local search of particle swarm optimization algorithm, the particle swarm algorithm with differential evolution algorithm is the local optimization solution as the initial population of generation of differential evolution operations, thickness of solving it is concluded that the optimal approximate solution, and it is concluded that the optimal thickness. The convection and radiation heat transfer coefficients, convection and radiation heat transfer, and skin temperature were calculated. Then, by using the extensibility of CFD simulation and the flexibility of environmental temperature setting, the human thermal radiation stress response model was embedded into the CFD simulation, to predict the real-time changes of human core temperature in a high-temperature thermal radiation environment. Combined with the core temperature threshold and exposure time, people's rescue operation time under different thermal radiation environment conditions can be reasonably scheduled and arranged to reduce the level of thermal stress, improve rescue efficiency and guarantee people's life safety. Finally, the thermal protection clothing is studied to determine the temperature distribution of each layer of thermal protective clothing. It provides a theoretical reference for the functional design of thermal protective clothing.