Pulsating heat pipes (PHPs) are passive heat transfer devices where the heat transfer is much higher as compared to the general heat transfer devices such as metal fins. The main reason for this is the two phase phenomenon happening inside PHPs with the oscillatory motion of the bubbles. It can be used in various applications, space satellites, laptops or any other place where you want heat transfer to be very high in a small temperature drop. CFD analysis for the PHP is tested with different working fluids binary mixtures like water-methanol and water-ethanol for 50% fill ratio viz., for different inner diameters of 2mm and 3mm. At evaporator boundary, heat flux that is equivalent to 10W to 70W is supplied and the condenser boundary is set as heat flux of range 1000w/m2 and in the adiabatic section heat flux is zero. A CFD modelling is done in ANSYS CFX with two turns of PHP. The temperature distribution across the heat pipe was measured. The performance parameters such as temperature difference between evaporator and condenser, thermal resistance evaluated. CFD results demonstrate the heat transfer characteristics observing the performance of PHP is a numerical approach. The obtained CFD results are compared with the experimental paper [1].The CFD analysis is performed and the outputs of the simulations are plotted in graphs and contours.