Closed Joint-Stock Company Research Articles

Morphological changes and luminescence of Escherichia coli in contact with Mn2O3 and Co3O4 ultrafine particles as components of a mineral feed additive.

The spread of antibiotic resistance and mineral depletion in soils encourages an intensive search for highly effective and environmentally safe bactericidal agents and sources of macro- and micro-elements. The most profitable solution would combine both the described tasks. Ultrafine particles (UFPs) have this functionality. Thus, this study aimed to analyze the bioluminescence and external morphological changes of Escherichia coli cells after contact with M2O3 and Co3O4 UFPs at effective concentrations (ECs). The antibiotic properties of the studied samples were determined on a multifunctional microplate analyzer TECAN Infinite F200 (Tecan Austria GmbH, Austria) by fixing the luminescence value of the bacterial strain E. coli K12 TG11 (Ecolum, NVO Immunotech Closed Joint Stock Company, Russia). Morphological changes in the cell structure were evaluated using a Certus Standard EG-5000 atomic force microscope equipped with NSPEC software (Nano Scan Technology LLC, Russia). The obtained results indicate high bactericidal properties of Co3O4 and Mn2O3 UFPs (EC50 at 3.1 × 10-5 and 1.9 × 10-3 mol/L, respectively) due to the degradation of the cell wall, pathological increase in size, disruption of septic processes, and loss of cytoplasmic contents. The prospects for the environmentally safe use of ultrafine materials are outlined. The limits of the dosages of Co3O4 and Mn2O3 UFPs recommended for further study in vitro and in vivo in feeding farm animals are established (no more than 4.9 × 10-4 mol/L for Mn2O3 UFPs and 1.5 × 10-5 mol/L for Co3O4 UFPs). The limitation of the work is the lack of experiments to determine the mechanisms of the toxic effect of UFP on bacteria, protein structures, and DNA and oxidative stress, which is planned to be performed in the future together with in situ and in vivo studies on animals.

РАБОЧИЕ БУДНИ УЛЬЯНОВСКОГО КОЖЕВЕННОГО КОМБИНАТА В 1970-е гг.

The article is based on the materials of the State Archive of the Modern History of the Ulyanovsk region and the State Archive of the Ulyanovsk region, which are introduced to the scientific world for the first time. The authors examine the history and organization of work at one of the light industry enterprises, the Ulyanovsk tannery plant. The main stories are devoted to the analysis of labor discipline, measures of material and moral incentives for workers. The authors pay attention to the scale of staff turnover and measures to reduce it, to suppress non-normative behavior, in particular alcoholism. A conclusion is drawn about the socio-economic importance of the enterprise for the regional economy during the Soviet period. The authors argue that the inherent potential and traditions of maintaining production made it possible to preserve the Ulyanovsk tannery plant in the changed conditions of the 1990s and the continue its activities as the Closed Joint Stock Company "Ulyanovsk Shoe Factory".

Конец колхозной жизни (на примере колхоза «Новая жизнь» Правдинского района Калининградской области)

Based on unpublished materials from the State Archive of the Kaliningrad region and the Archival department of the administration of the municipal entity “Pravdinsky Urban Dis­trict”, including minutes of general meetings and board sessions of the collective farm, mate­rials from the primary party organization, etc., this microhistorical study explores the final years of the “Novaya Znizn (New Life)” collective farm in the Pravdinsky district of the Ka­liningrad region. The research goal is to reconstruct the views of collective farm members on the processes occurring in the country in the late 1980s to early 1990s. The analysis presents the main challenges faced by the farm during the period of Perestroika. Despite numerous transformations initiated by M. S. Gorbachev in the agricultural sector, they did not lead to the expected qualitative changes. Phenomena such as rising prices and shortages of goods caused disillusionment with the ideas of Perestroika. The author examines the process of reor­ganizing the collective farm into a closed joint-stock company. The general conclusion is that, despite the possibility of organizing individual farming enterprises, the majority of peasants chose to preserve the established collective way of life. They saw it as a guarantee of support in the face of the critical economic situation in the Russian countryside in the early 1990s.

PECULIARITIES OF THE USE OF INNOVATIVE GROWTH REGULATORS IN POTATO AND SOYBEAN CULTIVATION IN THE FOREST-STEPPE OF THE PRIOB’E AREA

The authors cited the results of comprehensive experiments on the application of innovative environmentally acceptable growth regulators on industrial crops: potatoes and soybeans. The experiments were conducted in 2019-2021 in the soil and climatic zone of the drained forest-steppe in the conditions of chernozem on potato varieties, Lyubava (early) and Tuleevsky (medium maturing), and soybean on grain Zolotistaya (early maturing). These experimental fields belong to the Educational and Experimental Farm “Praktik” of Novosibirsk Region and the Closed Joint-Stock Company Livestock Breeding Farming “Irmen” of Novosibirsk Region. The maximum photosynthetic performance of Novosil and Ecofus applied to potatoes and soybeans is up to 19 % compared to control. The authors of the study treated crops before sowing as well as on the shoots before the beginning of the phase of budding. The yield against the growth regulators used increased significantly by 21-24 % when Novosil and Ecofus were applied during seed treatment and when spraying vegetative plants before the phase of budding. It was statistically established that the potato yield depended on variety by 30 %, on growth regulators by 33, and on conditions of the year by 23 %.

SIGNIFICANCE OF THE METALLURGICAL INDUSTRY OF AZERBAIJAN IN THE NON-OIL SECTOR, THE ROLE OF AZERGOLD CJSC IN THE ECONOMY OF THE REPUBLIC

Geological surveys carried out by the Closed Joint Stock Company (CJSC) AzerGold for the exploration of new deposits and expansion of production areas are giving positive results. For an effective assessment of reserves at the fields, AzerGold CJSC conducts intensive exploration work and drills deep wells in these fields. Since 2017, AzerGold CJSC has been mining Chovdar, Agyokhush, Tulallar, Marakh, Filizchay etc others and Jayirchay gold, as well as it carries out various works on fine metal deposits. The latest financial indicators of AzerGold CJSC give reason to say that it is a stable company. It is expected that AzerGold CJSC will react faster to the growth rates in the world markets due to the work carried out at new gold deposits and efficient use of resources. The net profit of a Closed Joint Stock Company has been growing at a higher rate over the years. AzerGold CJSC produces ingots and coins from Azerbaijani gold and silver in various historical designs. Bars and coins are currently sold in stores owned by Italdizain Group, Levata Group and SI Luxury World, which have a long history of selling premium goods. AzerGold CJSC will soon become better known in the local and international markets as a gold producer of the country. AzerGold CJSC issues bonds, increases the company's technological capabilities for gold production and strengthens production in order to bring more gold to the world market. Recent financial indicators of AzerGold CJSC give grounds to say that it is a stable company. The company's revenue, net profit and total capital of the company in 2019 increased several times compared to 2018. Keywords: AzerGold CJSC, geological exploration works, drilling works, production works, efficiency.

Determination of clemastine by the HPLC method in the blood

Topicality. Сlemastine fumarate (tavegil)-1-methyl-2 [2-α-methyl-p-chlorobenzhydryloxy)-ethyl]-pyrrolidine fumarate is the first generation H1-histamine receptor blocker. Сlemastine fumarate selectively inhibits histamine H1 receptors and reduces capillary permeability. The drug has a pronounced anti-allergic and antipruritic effect. Clemastine prevents the development of vasodilation and the smooth muscle contraction induced by histamine. Сlemastine fumarate has an isignificant anticholinergic activity, causes sedation. The drug is used to treat pruritus in psoriasis, multiple sclerosis and optic neuritis. Clemastine is characterized by the following side effects: increased fatigue, drowsiness, sedation, weakness, lethargy, impaired coordination of movements; nausea, vomiting, decreased blood pressure, palpitations, hemolytic anemia, skin rash, anaphylactic shock. In case of an overdose, the drug has a neurotoxic effect, which manifests itself in impaired consciousness with the development of generalized anticholinergic convulsive syndrome. The urgent task for monitoring the treatment effectiveness of the population with сlemastine fumarate and diagnosis of drug intoxication is the choice of highly sensitive and selective research methods of its analysis in pharmaceuticals and biological matrices during the treatment. Aim. To develop an algorithm for directed analysis of clemastine in biological extracts from the blood using a unified method of the HPLC research. Materials and methods. The extraction of clemastine was performed with chloroform at Ph 9.0. The extracts were purified from impurities by a combination of TLC and extraction with hexane. The TLC purification and identification of clemastine were carried out under optimal conditions: the system of organic solvents – methanol – 25 % solution of ammonium hydroxide (100 : 1.5) and chromatographic plates – Sorbfil PTLC-AF-A, Rf сlemastine = 0.60 ± 0.03. To detect clemastine, the most sensitive location reagents were used –UV light (λ = 254 nm) and Dragendorff’s reagent modified by Mounier. The chromatographic analysis was performed on a “Milichrome A-02” microcolumn liquid chromatograph (EkoNova, Closed Joint-Stock Company, Russia) under standardized HPLC conditions: the reversed-phase variant using a metal column with a non-polar absorbent Prontosil 120-5C 18 AQ, 5 μm; the mobile phase in the linear gradient mode – from eluent А (5 % acetonitrile and 95 % buffer solution – 0.2 М solution of lithium perchlorate in 0.005 М solution of perchloric acid) to eluent B (100 % acetonitrile) for 40 min. Regeneration of the column was conducted for 2 min with the mixture of solvents; the flow rate of the mobile phase was 100 μl/min, the injection volume – 4 μl. The multichannel detection of the substance was performed using a two-beam multi-wave UV spectrophotometer at 8 wavelengths of 210, 220, 230, 240, 250, 260, 280, and 300 nm; the optimal value of the column temperature – 37-40 °С and the pump pressure – 2.8-3.2 MPa. Results and discussion. Isolation of clemastine from the blood was performed according to the method developed, including the extraction with chloroform at pH 9.0; the extraction purification of extracts with hexane from impurities; the TLC purification and identification of clemastine. Using the unified HPLC method clemastine was identified by retention parameters and spectral ratios. For the quantitative determination, a calibration graph or the straight line equation corresponding to this graph were used. The results obtained indicated the reliability and reproducibility of the method. It was found that the relative uncertainty of the average result in the analysis of clemastine in the blood was ε = ± 4.63 %, the relative standard deviation of the average result was RSDx = 1.67 %. Conclusions. Clemastine was extracted with chloroform at pH 9.0 from the blood. Purification of extracts from co-extractive compounds was performed by combining TLC and extraction with hexane. It has been found that when isolating сlemastine from the blood according to the methods developed it is possible to determine 36.05-39.55 % of the substance (ε = ± 4.63 %, RSDx = 1.67 %). The method of TLC purification and identification of сlemastine in biogenic extracts was tested under the optimal conditions: the system of organic solvents – methanol – 25 % solution of ammonium hydroxide (100 : 1.5), the use of reagents – UV light, Dragendorff’s reagent modified by Mounier, Rf сlemastine = 0.60 ± 0.03 (Sorbfil PTLC-AF-A). The unified HPLC method for identification and quantification of сlemastine was tested in biogenic extracts from the blood according to the algorithm of the directed analysis developed. It has been found that сlemastine can be identified by the retention time – 25.997-26.011 min; the retention volume – 2599.7-2601.1 μl; spectral ratios – 0.741; 0.536; 0.096; 0.023; 0.027; 0.005; 0.003. The сlemastine content was determined by the equation S = 0.15 · 10-3 С + 0.14 · 10-3; the correlation coefficient was equal to 0.9998. Chromatographic methods can be recommended for implementation in practice of the Bureau of Forensic Medical Examination, poison control centers, clinical laboratories regarding the study of medicinal substances in biological objects.

Retrospective and Perspective View of the Next Stage of Privatization in Azerbaijan

When oil prices fell on world markets, privatization in Azerbaijan came to the fore again. This time, the companies to be privatized were transferred to the management of the Azerbaijan Investment Holding on November 5, 2020, for rehabilitation. The list of such state companies and enterprises, as well as joint-stock companies with state share, include the State Oil Company of the Republic of Azerbaijan (SOCAR), Azerbaijan Airlines Closed Joint Stock Company (CJSC), Azerbaijan Railways CJSC, Azerbaijan Caspian Shipping Company CJSC, AzerGold CJSC, Azerenergy Open Joint Stock Company (OJSC), International Bank of Azerbaijan OJSC, Azerbaijan International Telecom (AzInTelecom) LLC, Azerpocht LLC, Baku Telephone Communication LLC,etc. The main directions of the budget and tax policy of the Republic of Azerbaijan in 2021-2024 state that special attention will be paid to stimulating the privatization of state property and creating more favorable conditions for investors next year. However, the projected revenues from privatization in 2021-2024 (111.0 million manats in 2021, 66.0 million manats in 2022, 62.0 million manats in 2023, and 64.0 million manats in 2024) show that this source will receive more funds this year than in the next years. The Azerbaijani government is going to re-privatize with dirty and dubious privatization practices. Therefore, mistakes made in the 1st and 2nd phase of privatization should be studied and lessons should be taken during.

Analysis of the Efficiency of Using Assets Based on Accounting

Considering the advance of technologies and methods aimed at improving the quality of management of the asset complex, new requirements for justifying the effectiveness of funds invested in assets are constantly appearing, they are constantly evolving and becoming more viable, which determines the theoretical and practical interest in the issues studied by the authors. The main purpose of the article is to offer methodological developments and recommendations for analyzing the effectiveness of the use of the asset complex by a research and production concern on the basis of financial statements, to identify reserves and give recommendations for more efficient usage of resources. The subject of the research is activities of an enterprise related to the management of the asset complex. In addition to the introduction of new methods of economic analysis, the authors also developed a generalized model for managing the asset complex in the form of a software product. This model was applied to two real research and production complexes, one of which is the largest Federal Research and Production Center Closed Joint Stock Company Research and Production Concern (Association) “Energia”. The developed model can be applied with the purpose of effective management of the asset complex by the largest industrial companies. The results of the research presented in this scientific article will allow specialists to improve the quality of analytical work in the field of economic analysis of enterprise assets and the search for reserves for their effective use.

Determination of quifenadine by HPLC method in blood

Topicality. Quifenadine hydrochloride (phencarol) – quinuclidinyl-3-diphenyl carbinol hydrochloride – first generation H1-histamine receptor blocker. The drug reduces the content of histamine in tissues due to the activation of the enzyme diamine oxidase, which breaks down up to 30 % of tissue histamine. Quifenadine hydrochloride is superior to diphenhydramine in duration of antihistamine action. Unlike diphenhydramine and diprazine, quifenadine does not inhibit the CNS, is characterized by weak sedative properties. Quifenadine hydrochloride can be used in the development of tolerance to other sedative antihistamines. Quifenadine hydrochloride is used to treat anaphylactic shock, urticaria, hay fever, Quincke’s edema, dermatoses, allergic rhinitis, food and drug allergies. In case of overdose of quifenadine hydrochloride causes dryness of the mucous membranes, headache, vomiting, stomach pain and dyspepsia. At high doses, it can affect the cardiovascular system, gastrointestinal tract, liver and kidneys. Detection and quantification of quifenadine hydrochloride in pharmaceuticals and biological matrices during treatment are based on the choice of highly sensitive and selective research methods, which is an urgent task for monitoring the effectiveness of treatment of the population with antihistamines and diagnosis of drug intoxication.Aim. To develop an algorithm for directed analysis of quifenadine in biological extracts from blood using a unified method of HPLC research.Materials and methods. The extraction of quifenadine was carried out with chloroform at pH 9.0. The extracts were purified from impurities by a combination of TLC and extraction with hexane. TLC purification and identification of quifenadine were carried out under optimal conditions: system of organic solvents – chloroform-n-butanol-25 % solution of ammonium hydroxide (70:40:5) and chromatographic plates – Sorbfil PTLC-AF-A. For the detection of quifenadine, the most sensitive location reagents were used – UV light (λ = 254 nm) and reagent Dragendorff in the modification of Mounier. Chromatographic analysis has been carried out on a microcolumn liquid chromatograph “Milichrome A-02” (EkoNova, Closed Joint-Stock Company, Novosibirsk, Russia) using standardized HPLC conditions: reversed-phase variant with the use of metal column with non-polar absorbent Prontosil 120-5C 18 AQ, 5 μm; mobile phase in the mode of linear gradient – from eluent А (5 % acetonitrile and 95 % buffer solution – 0.2 М solution of lithium perchlorate in 0.005 М solution acid perchloric) to eluent B (100 % acetonitrile) as during 40 min. Regeneration of column has been conducted during 2 min with mixture of solvents; the flow rate of the mobile phase has been formed 100 μl/min, injection volume – 4 μl. Multichannel detection of the substance was carried out using a two-beam multi-wave UV spectrophotometer at 8 wavelengths of 210, 220, 230, 240, 250, 260, 280, and 300 nm; the optimal value of column temperature – 37-40 °С and pressure of pump – 2.8-3.2 MPa.Results and discussion. Isolation of quifenadine from blood has been carried out according to the developed method, including extraction with chloroform at pH 9.0; extraction purification of extracts with hexane from impurities; TLC purification and identification of quifenadine. By using a unified HPLC method, quifenadine was identified by retention parameters and spectral ratios. For quantitative determination, a calibration graph or a straight line equation corresponding to this graph were used. The obtained results indicated the reliability and reproducibility of the method. It was found that the relative uncertainty of the average result in the analysis of quifenadine in blood was e = ± 6.65 %, the relative standard deviation of the average result was RSDx = 2.25%.Conclusions. Quifenadine was extracted with chloroform at pH 9,0 from blood. Purification of extracts from co-extractive compounds was performed by combining TLC and extraction with hexane. It was established that when isolating quifenadine from blood according to the developed methods it is possible to allocate 32.5-37.6 % of substance (e = ± 6.65 %, RSDx = 2.25 %). The method of TLC purification and identification of quifenadine in biogenic extracts was tested under optimal conditions: system of organic solvents – chloroform-n-butanol-25 % solution of ammonium hydroxide (70:40:5), location reagents – UV light, reagent Dragendorff in the modification of Mounier, Rf quifenadine = 0.25-0.30 (Sorbfil PTLC-AF-A). The unified HPLC method for identification and quantification of quifenadine has been tested in biogenic extracts from blood according to the developed algorithm of directed analysis. It was found that quifenadine can be identified by retention time – 20.27 ± 0.03 min; retention volume 2026.9 ± 0.34 μl; spectral ratios – 0.634; 0.255; 0.041; 0.022; 0.027; 0.001; 0.001. Equation was used to determine the quifenadine content S = 0.42·10-3 С + 0.94·10-3 the correlation coefficient was equal to 0.9985.Chromatographic techniques can be recommended for implementation in practice of the Bureau of Forensic Medical Examination, poison control centers, clinical laboratories regarding the study of medicinal substances in biological objects.

Substantiation of technologies and technical means for disposal of mining and metallurgical waste in mines

The object of research is environmental and resource-saving technologies in underground mining of mineral deposits with the laying of the developed space. One of the most problematic places is the delivery of hardening filling mixtures to the place of their installation and the lack of components for their preparation. This increases the importance of managing the state of ore-bearing massifs and the preservation of the earth’s surface.The paper presents the main scientific and practical results of the substantiation of technologies and technical means for the disposal of mining and metallurgical production wastes into underground mined spaces (man-made voids) as components of hardening filling mixtures. Methods of theoretical generalizations are described using mathematical statistics, physical and mathematical modeling, with calculations and feasibility studies, laboratory and field experimental studies, industrial tests in operating enterprises. It is established that the use of vibration, mechanical and electroactivation of the components of the hardening filling mixture in mining enterprises leads to an increase in the activity of substandard materials by up to 10–40 % for each device. In particular, the enrichment of substandard inert materials at the vibrating screen GV-1.2/3.2 (Ukraine) increases the activity by 15–20 %. It is proved that the activation of binders (blast furnace granulated slag) in the DU-65 disintegrator (Disintegrator, Estonia) increases the activity of the binder by 20–25 %, with the output of the active class of fractions of 0.074 mm in size – by 55 % versus 40 % in ball mills. Vibration transport unit are recommended, which increase the activity of the solid components of the hardening filling mixture by 10–15 %, and electrodialysis apparatus for activating mixing water increase its activity by 30–40 %. It is shown that the use of vibration gravity transport systems ensures the filling of the filling mixture at a distance exceeding the height of the vertical stand by 15–20 times. A set of technical means is proposed for activating the components of hardening filling mixtures (binder, inert aggregate and electrochemically purified mine mixing water) during the manufacture and transportation of them to the installation site. This complex was introduced at such mining enterprises as:– State Enterprise «Eastern Mining and Processing Plant» and Balaklava Mining Administration (Ukraine);– Joint-stock company «Tselinnyi Mining and Chemical Combine» (Republic of Kazakhstan);– Public Joint-Stock Company «Priargunsky Industrial Mining and Chemical Association» and Closed Joint-Stock Company «Uralzoloto» (Russian Federation) in other developed mining countries.

The analysis of activity of the construction organizations based on studying of profit indicators

The aim of research. Construction belongs to one of types of economic activity and key industry, thereby having significant effect on economy and growth of well-being of nation and its economic entities. However, the crisis conditions of the last few years could not but affect the construction activity. In this regard, the analysis of the existing situation in the sphere of construction and studying of the factors, influencing increase in efficiency of activity of the construction organizations is a relevant task. The goal of this article is to study and analyze construction area by studying individual organizations, which were chosen in database “SPARK”. One of the most important quality indicators, characterizing the organization’s activities is profit, which is the final financial result and allows replenishing the organization’s financial resources. The work has evaluated the effectiveness of the formation and use of profits of the analyzed organizations, identifying existing problems. The profit is a factor that determines productivity of organization, its liquidity, ability to pay, financial sustainability in the modern market. A part of research performs economics and statistics analysis of main economic indicators, characterizing the formation and use of profit in organizations of the construction industry, and financial activity analysis of the two largest construction organizations in part of profit formation and its use.Materials and methods. Informational background is statistical data and analytical information about financial activity of construction organizations. Methodological basis of the research is statistical methods of data analysis: comparative and dynamical analysis, variational analysis, correlation and regression analysis.Results. The role of construction area in economics of Russia was analyzed. Construction is the key industry that influences the formation of the national economy. Main indicators that describe efficiency of activity of construction organizations were considered; analysis of number of indicators about activity of construction area was implemented; a group of organizations was chosen by using database “SPARK”; interrelationship between earnings and net profit was studied, comparative analysis between Ltd “Stroyregistr” and Closed Joint Stock Company “SEDO” is implemented. The main types of profit such as gross profit, profit on sales, before-tax profit and net profit were considered. It is worth noting that these types of profit are interrelated, since one category arises from the other depending on the income and expense items inherent in one or another type of profit. Analysis of the state of construction organizations involves the study of factors affecting their activity. For this purpose correlation and regression analysis was used in the work. Conclusion. To study the process of forming and using profits as an object of research, Ltd “Stroyregistr”, which operates in Moscow region, was chosen. As the competitor, Closed Joint Stock Company “SEDO”, which is also carrying out activity in Moscow region, was considered. During the analysis of these organizations, it was revealed that the activity of Ltd “Stroyregistr” is more stable and successful compared to Closed Joint Stock Company “SEDO”, which showed a sharp decline in financial indicators in 2016. However, the value of profitability on net profit in Ltd “Stroyregistr” is lower than the industry average value, which is associated with a low value of the net profit.As a result, the reasons that influenced the low value of net profit were identified. One of the main reasons is the high cost of the rendered services.

Increase in efficiency of the land relations as one of factors of development of agro-industrial complex

In article formation and development of the land relations during the period from 2000 to 2016 on the example of the Voronezh region is considered. Need of a land reform which purpose in agriculture was a transformation of the land relations providing efficiency of use of land resources is shown. In article it is shown that objectives are partially solved. By 2016 joint stock companies, the joint-stock company, closed joint stock company, Ltd company, KFH, etc. were created, modern legal forms therefore the conclusion is drawn that limited liability companies at the moment prevail Are analysed, they make 73,8%. Results of their work in recent years are shown. The number of the unprofitable enterprises in 2016 in comparison with 2005 has decreased in percentage terms by 5,5 times and is only 6%, and profitable – 94%. The profit size for this period has increased more than by 10 times. Their characteristics and shortcomings are considered. It is noted that increase in efficiency of the land relations was promoted in no small measure by the following conditions: use of new technologies, introduction new highly productive, grades, rational use of fertilizers, acquisition of the new equipment, observance of crop rotations, improvement of personnel policy, etc. During land reforms due attention hasn't been paid to legal support of the mechanism of optimization of use of the earth that seriously slows down development of new land legal relations. Besides, the material and technical resources are still insufficiently created, selection and breeding work isn't completely restored, there are shortcomings and of formation of the financial and credit relations. For more effective use of land resources a number of actions for improvement of the organizational and economic mechanism are offered.

ДОСЛІДЖЕННЯ ІНФУЗІЙНИХ РОЗЧИНІВ НА УКРАЇНСЬКОМУ ФАРМАЦЕВТИЧНОМУ РИНКУ

ДОСЛІДЖЕННЯ ІНФУЗІЙНИХ РОЗЧИНІВ НА УКРАЇНСЬКОМУ ФАРМАЦЕВТИЧНОМУ РИНКУ

Application of Thermomechanically Treated Ti-Ni SMA

The main fields of the practical application of Ti-Ni-based alloys, with shape memory and superelasticity effects, in engineering and medicine, have been identified in the past decade. There are temperature-sensitive elements for the actuators, damping devices, fasteners, medical instruments and implants (correctors, clamps, stents), for trauma, spine, dentistry, soft tissues and vessels. The development of science and high technologies to produce semi-finished methods (thin-walled tubes, tapes and thin wire), as well as processing methods (laser cutting and welding) of Ti-Ni-based shape memory alloys (SMA) over the last 10 years has contributed to the creation and implementation into practice of more complicated and advanced devices, based on solid and porous shape memory materials. New technologies require not only the creation of fundamentally new shape-memory devices, but also, more importantly, the achievement of the highest possible functional properties (FP) of the SMA, by creating an optimal type of structure by thermomechanical treatment. Techniques for the regulation of FP are different for Ti-Ni SMA of different compositions. For the non-ageing equiatomic and near-equiatomic Ti-Ni SMA, the basic method of FP control is thermomechanical treatment (ТМT), including severe plastic deformation (SPD), forming various structures: from a well-developed recovered and polygonized dislocation substructure to a nanocrystalline structure. In the framework of the scientific direction, fundamental and applied research in the field of SMA thermomechanical treatment (TMT) has been carried out since 1977, by the Shape Memory Alloys Research Group of the National University of Science and Technology MISIS.The present review provides a brief description of the devices running on the shape-memory effect and superelasticity, developed jointly by NUST MISIS and various companies: Globetek 2000 Ltd (Melbourne, Australia); Semashko Central Clinical Hospital of Ministry of Railway Communications; Closed Joint-Stock Company ARMGAS-NT; Scientific-production Enterprise AVTOMATPROM (Moscow, Russia), et al. In addition, it presents the analysis of medical problems that can be solved using data devices, including work items of thermomechanically treated Ti-Ni SMA.

Degradation of 09H2S steel under the conditions of petroleum refining

We study the changes in the properties of 09H2S + 08Kh13 bimetal from the K-6 and K-2 columns of the “LYNYK” Closed Joint-Stock Company after operation for 27 and 12 yr, respectively. At 20 and 200°C, the mechanical properties of 09H2S steel after operation are compared with the properties of the metal in the as-delivered state. It is shown that, the most informative parameters among the mechanical characteristics of the metal are σ0.2, σu, and δ, and the complex quantity σ0.2 /σu. The relative narrowing ψ and impact toughness are insufficiently informative due to the significant spread of the data of measurements. The long-term operation of the bimetal results in the pitting corrosion of the inner surface of the column, corrosion cracking in the heat-affected zone of welded joints, and knife-line corrosion. It is shown that the theory of dislocations adequately explains the causes and mechanism of hardening of steels operating in corrosive media.

Biooxidation of Refractory Gold Sulfide Concentrate of Olympiada Deposit

Results of research on technological processes for treatment of refractory gold-arsenic ores using bioleaching of concentrates are presented. In October 2001 the first line of bioreactors on Mill-2 began operation with projected throughput of 3 million tons a year. In July 2007 Mill-3 began operation with projected throughput of 5 million tons a year. At present the closed joint stock company Gold Mining Company «Polyus» occupies a leading position in gold extraction from hard rocks in the Russian Federation. Processing of refractory gold-arsenic ores is conducted on Mill-2 and Mill-3 by a flotation-cyanide scheme using a unique biooxidation technology, BIONORD®, designed to process concentrates in the extreme climatic conditions of the North, . The achieved productivity of the Olympiada Mining Combine, from the processing of both oxidized and refractory ores of the Olympiada deposit, is 26.7 tons of gold a year. The gold is mostly present as finely dispersed and submicroscopic particles in close association with sulfide minerals, usually pyrite, pyrrhotite, arsenopyrite and antimonite. The average productivity of the lines is 1000 t/day. The process time is 100-150 h. The pulp density is 150-200 g/l. The working temperature is 39-40oC. The microbial association is represented by three species of chemolithotrophs: “Sulfobacillus olympiadicus”, Leptospirillum ferrooxidans, and Ferroplasma acidiphilum present in proportions 60-80%, 10-20%, and 10-17%, respectively. During the process 87% of sulfide minerals are oxidized. Thus, 98% of the pyrrhotite, 95.4% of the arsenopyrite, 70% of the antimony sulfides and 60% of the pyrite is oxidised. Biooxidation enables 97% of the gold to be released.

New Catalysts for Hydrorefining of Crude Oil Cuts. Experience in Use

The results of using new catalysts of hydrogenation processes in oil refineries are reported. These catalysts were developed at KATAKhIM Corp. Ltd. and are manufactured by Industrial Catalysts Closed Joint—Stock Company (Tyumen Oil Company) under the brand name RK. Experience in using them in catalytic systems utilizing domestic technologies demonstrates the possibility of manufacturing environmentally clean diesel fuel that satisfies international requirements.

92. Concerning the Complaint of the Closed Joint-Stock Company Commercial Production Company “Pyramid” Regarding the Violation of Constitutional Rights and Freedoms by Point 4 of Article 14 of the Law of the Russian Federation “On Currency Regulation and Currency Control”

92. Concerning the Complaint of the Closed Joint-Stock Company Commercial Production Company “Pyramid” Regarding the Violation of Constitutional Rights and Freedoms by Point 4 of Article 14 of the Law of the Russian Federation “On Currency Regulation and Currency Control”

The Closed Joint-Stock Company Amico (X-ray Engineering)

The Closed Joint-Stock Company Amico (X-ray Engineering)

37. In the Case Concerning Verification of the Constitutionality of the Provisions of the First Part of Article 131 and the First Part of Article 380 of the Customs Code of the Russian Federation in Connection with the Complaint of the Closed JointStock Company “Sibirskoe Agenstvo ‘Express’” and of Citizen S. I. Tenenev, as well as the Complaint of the

37. In the Case Concerning Verification of the Constitutionality of the Provisions of the First Part of Article 131 and the First Part of Article 380 of the Customs Code of the Russian Federation in Connection with the Complaint of the Closed JointStock Company “Sibirskoe Agenstvo ‘Express’” and of Citizen S. I. Tenenev, as well as the Complaint of the