The coupler knuckle of railway wagon is a complex forging component with big section change. In this paper, a near-net-shape forming process for coupler knuckle based on closed-die forging without flash was proposed and the preforming operation was designed and optimized. Firstly, the shape and the dimension of the preforging were preliminarily designed based on the geometric features of forged knuckle and the flow characteristics of metal in the forging process, and then a multi-objective optimization approach based on the filling capacity, deformation homogeneity, and damage degree of forgings was established, and the response surface method combined with the finite element simulation was used to obtain the optimum geometric parameters of preforging. In order to verify the effectiveness of the near-net-shape forming process and the optimized results on preform design, forming experiments and measurements were carried out; the analyzed results show that based on the designed preforging, near-net-shape forming process is capable of producing coupler knuckle of high quality and without forming defect.