This study is conducted with the aim of investigating the efficiency of open and closed-circuit molybdenite ore comminution processes (primary and secondary mill, respectively), through mineralogical study of mills feed and product. For this purpose, particle size distribution, minerals distribution, degree of liberation and interlocking of minerals in mills feed and product were studied. According to the results, chalcopyrite, molybdenite, pyrite and covellite constitute the major part of the mineral composition of open-circuit mill feed. Minerals at the mill product, in the order of abundance include liberated molybdenite particles, liberated chalcopyrite and interlocked chalcopyrite with pyrite, liberated and interlocked pyrite particles, and associated silicate gangues. The d50 values of the feed and product particles of the open-circuit mill are equal to 13.80 and 13.40 microns, respectively. Degree of liberation of molybdenite for the feed and product of this mill is almost the same and is equal to 98.0%. Closed-circuit mill feed includes, in order of is abundance, liberated molybdenite particles in the form of blades and irregular polygonal shapes, liberated and interlocked chalcopyrite, and liberated and interlocked pyrite particles with gangue minerals. Molybdenite particles in the mill product are almost completely liberated, and the degree of liberation values of chalcopyrite and pyrite are 84.40% and 91.40%, respectively. According to particles size distribution of the feed (d50 equal to 25.03 microns) and the product (d50 equal to 24.24 microns) of closed-circuit mill, it can be stated that comminution is not well-operated in closed-circuit mill due to the low solid percentage of closed-circuit mill feed and the inefficiency of hydrocyclone. Examination of Mo, Cu, and Fe grade variations for 10 days in both off and on modes of mill shows that closed-circuit mill does not have an impact on comminution process. It can even be concluded that the mill has a destructive effect the flotation process by producing slimes.