Close Proximity Research Articles

Design of a novel compact low specific absorption rate multiple input multiple output antenna for 5G sub-6 GHz terminals

This investigation presents a new design and analysis of a fourteen elements massive multiple input multiple output (MIMO) compact low specific absorption rate (SAR) antenna system for 5G and beyond terminals. The MIMO antennas are realized for sub-6 GHz LTE-band 46 (5.1-5.8 GHz) long-term evolution 5G wireless communication services. The proposed antenna system is designed on an FR-4 dielectric constant 4.3 substrate consisting of the main board and four sideboards. The radiating elements are developed on the sideboards consisting of a monopole antenna and two metamaterial unit cells, as well as the feed line is designed on the principal board. The overall volume of the proposed structure is 150×80×7.5 mm. Through the use of the metamaterial unit cells, the proposed antennas have been arranged in close proximity without developing a strong mutual coupling. The results obtained were very important in terms of impedance matching, isolation among the antennas, and good gain. Even, the SAR analysis at the operating frequency band of 5.5 GHz proves that the proposed MIMO antenna system satisfies safety standards set for human exposure at the international level. Therefore, the proposed massive MIMO antenna structure is a potential solution for future communication applications.

The geography of technological innovation systems - The case of forest-based biofuels in a Swedish region

Geographical proximity exerts a substantial influence on structural evolution, developmental trajectory, and pace of sociotechnical system growth. This study explores this aspect within the context of the development of forest biomass-based biofuel technology, employing a Technological Innovation System (TIS) framework with the lens of geographical proximity utilization of system components. The research employed a combination of document analysis and interviews with key system stakeholders as data collection methods. The analysis reveals that the close geographical proximity of the system components and technologies, encompassing both technical aspects and sectors, did not result in synergetic effects, in contrast to prior TIS research findings. Rather than fostering collaboration, it has engendered a competitive dynamic, partially driven by actors vying for knowledge leads and funding from both regional and national agencies. Consequently, the potential benefits of geographical proximity of system components remain largely untapped. In light of these results, this study offers practical recommendations for exploiting untapped opportunities, advocating for more strategic use of geographical proximity to foster system technology development and enhance its role in national TIS development. This case study enriches sustainability transition literature by providing valuable insights into the role of geographical proximity in innovation processes.

Study of γ-Ray Emission from a Compact Radio Galaxy with the Fermi Large Area Telescope

The radio galaxy PKS 1007+142 is classified as a compact steep-spectrum source (CSS) and belongs to the class of young active galactic nuclei (AGNs). In this paper, we investigate the γ-ray emission from this CSS by conducting a comprehensive analysis of the 15 yr Fermi Large Area Telescope (Fermi-LAT) observation data. The Fermi-LAT latest Source Catalog, 4FGL-DR4, includes an unassociated γ-ray source, 4FGL J1010.0+1416, located at 0.°24 away from the radio position of PKS 1007+142. Using the 15 yr Fermi-LAT observation data, we reestimate the best-fit position of the γ-ray source and find that PKS 1007+142 is in close proximity to the γ-ray source and falls within its 68% error circle. Therefore, we conclude that PKS 1007+142 is the most plausible counterpart to the unassociated LAT source with detection test statistics ∼ 43.4 (∼6.6σ). PKS 1007+142 exhibits a steep power-law spectrum in the 0.1–300 GeV band, with a photon spectral index (Γ γ ) of 2.86 ± 0.17. The average flux in the considered time interval is (2.14 ± 0.34) × 10−12 erg cm−2 s−1. Comparing PKS 1007+142 with other γ-ray emitting AGNs in both the L γ –Γ γ and L γ –L 1.4 GHz planes, it shows a softer γ-ray spectrum and lower luminosity compared to other γ-ray emitting CSSs. Furthermore, the possible origins of γ-ray in PKS 1007+142 are also discussed.

Closeby Habitable Exoplanet Survey (CHES). I. Astrometric Noise and Planetary Detection Efficiency Due to Stellar Spots and Faculae

The Closeby Habitable Exoplanet Survey (CHES) is dedicated to the astrometric exploration for habitable-zone Earth-like planets orbiting solar-type stars in close proximity, achieving unprecedented microarcsecond precision. Given the elevated precision, meticulous consideration of photocenter jitters induced by stellar activity becomes imperative. This study endeavors to model the stellar activity of solar-type stars, compute astrometric noise, and delineate the detection limits of habitable planets within the astrometric domain. Simulations were conducted for identified primary targets of CHES, involving the generation of simulated observed data for astrometry and photometry, accounting for the impact of stellar activity. Estimation of activity levels in our sample was achieved through chromospheric activity indices, revealing that over 90% of the stars exhibited photocenter jitters below 1 μas. Notably, certain proximate stars, such as α Cen A and B, displayed more discernible noise arising from stellar activity. Subsequent tests were performed to evaluate detection performance, unveiling that stellar activity tends to have a less pronounced impact on planetary detectability for the majority of the stars. Approximately 95% of the targets demonstrated a detection efficiency exceeding 80%. However, for several cold stars, e.g., HD 32450 and HD 21531, with the habitable zones close to the stars, a reduction in detection efficiency was observed. These findings offer invaluable insights into the intricate interplay between stellar activity and astrometric precision, significantly advancing our understanding in the search for habitable planets.

Barriers to Pulmonary Rehabilitation.

Pulmonary rehabilitation (PR) is one of the most effective therapies for chronic respiratory diseases, yet it is significantly underutilized. There are several patient-related, geographic, societal, and health system-related barriers to PR. People with chronic respiratory disease face a collectively high burden of treatments including health care provider visits, medications, oxygen and other durable medical equipment, and providers' recommendation to undertake PR may be considered an added burden more than a likely benefit. Transportation difficulties, lack of insurance coverage, competing time priorities, low knowledge of PR, lack of perceived likely benefit, comorbidities, and other factors also pose obstacles to participation in PR for patients. Geographic availability of PR is heterogenous; in the United States, out-patient center-based PR programs are often not available within close proximity to patients' residence, posing barriers to patients' access to it. PR programs are lacking altogether in many areas; rural areas are particularly affected. Existing PR programs are often poorly funded and underresourced. Socioeconomic and racial disparities also influence patients' likelihood of receiving PR. Also, health care professionals (HCPs) often do not refer their patients with chronic respiratory disease to PR, owing to a lack of knowledge and awareness of its content and benefits, patient candidacy, or of the referral process. A limited number of multidisciplinary HCPs trained in PR likely also contributes to limited access to PR for patients. Collectively, these multifaceted barriers to PR create unacceptable health care disparities. Strategies to address barriers to PR are urgently needed in order to enable individuals who need to receive it.

Жалобы на когнитивные нарушения при унилатеральной компрессии височной доли

<p>Awareness of cognitive deficits, as a rule, occurs in the form of «memory complaints». Spontaneous narration of problems reveals their semantic hierarchy and can be a model for generating a spontaneous flow of thoughts and memories with the activity of the default brain network. The objective of the study was to study the nature of spontaneously expressed complaints about memory by patients with mild compression of the temporal regions of the resting network of the brain. The study was conducted in a homogeneous clinical group of 48 patients with extracerebral benign neoplasms located in close proximity to the medio-basal parts of the left (25 people) or right (28 people) temporal lobe. The tumor compresses these parts, but does not infiltrate the brain substance. With left-sided compression, complaints about verbal processes dominated, and their quantitative predominance over similar complaints was recorded in the group with right-sided compression and in the control group of healthy subjects (24 people). The severity of cognitive complaints with left-sided exposure to the brain revealed a negative correlation with experimental indicators of the success of spatial distribution of attention and simultaneous perception. With right-sided compression, spontaneously generated cognitive complaints revealed a dependence on the number of recognition errors in the AVP test, but this dependence was paradoxical: the worse this memory indicator was, the fewer cognitive complaints patients presented. The phenomenology of neural network compression makes it possible to register hemispheric specificity in spontaneously generated thoughts and memories.</p>

A Novel Use of Autologous Fibrin by Intracatheter Injection in Persistent Postoperative Biliary Defects: Technical Note on a Preliminary Experience.

To introduce percutaneous selective injection of autologous platelet-rich fibrin as a novel technique for persistent bile leakage repair and sharing the results of our preliminary experience. Seven patients (57.1% females; mean age 69.6 ± 8years) with the evidence of persistent bile leak secondary to hepatobiliary surgery and ineffective treatment with percutaneous transhepatic biliary drainage were submitted to fibrin injection. Platelet-rich fibrin, a dense fibrin clot promoting tissue regeneration, was obtained from centrifuged patient's venous blood. Repeated percutaneous injections through a catheter tip placed in close proximity to the biliary defect were performed until complete obliteration at fistulography. Technical and clinical success were evaluated. Bile leaks followed pancreaticoduodenectomy in five and major hepatectomy in two patients. Technical success defined as fibrin injection at BD site was achieved in all seven patients, and clinical success defined as a complete healing of the BD at fistulography was achieved in six patients. The median time to BD closure was 76.7 ± 40.5days and the average procedure number was 3 ± 1 per patient. In one patient, defect persistance after four treatments required gelatin sponge injection. No major complications occurred. One case of post-procedural transitory hyperpirexia was registered. In persistent biliary defects, despite prolonged biliary drainage stay, percutaneous injection of autologous platelet-rich fibrin appears as a readily available and feasible emergent technique in promoting fistulous tracts obliteration still mantaining main ducts patency.

Hydrodynamic Behavior of a Submerged Spheroid in Close Proximity to the Sea Surface

Hydrodynamic Behavior of a Submerged Spheroid in Close Proximity to the Sea Surface

Immune cell patterns before and after neoadjuvant immune checkpoint blockade combined with chemoradiotherapy in locally advanced esophageal squamous cell carcinoma

BackgroundNeoadjuvant immune checkpoint blockade (ICB) combined with chemoradiotherapy offers high pathologic complete response (pCR) rate for patients with locally advanced esophageal squamous cell carcinomas (ESCC). But the dynamic tumor immune microenvironment modulated by such neoadjuvant therapy remains unclear.Patients and methodsA total of 41 patients with locally advanced ESCC were recruited. All patients received neoadjuvant toripalimab combined with concurrent chemoradiotherapy. Matched pre- and post-treatment tissues were obtained for fluorescent multiplex immunohistochemistry (mIHC) and IHC analyses. The densities and spatial distributions of immune cells were determined by HALO modules. The differences of immune cell patterns before and after neoadjuvant treatment were investigated.ResultsIn the pre-treatment tissues, more stromal CD3 + FoxP3 + Tregs and CD86+/CD163 + macrophages were observed in patients with residual tumor existed in the resected lymph nodes (pN1), compared with patients with pCR. The majority of macrophages were distributed in close proximity to tumor nest in pN1 patients. In the post-treatment tissues, pCR patients had less CD86 + cell infiltration, whereas higher CD86 + cell density was significantly associated with higher tumor regression grades (TRG) in non-pCR patients. When comparing the paired pre- and post-treatment samples, heterogeneous therapy-associated immune cell patterns were found. Upon to the treatment, CD3 + T lymphocytes were slightly increased in pCR patients, but markedly decreased in non-pCR patients. In contrast, a noticeable increase and a less obvious decrease of CD86 + cell infiltration were respectively depicted in non-pCR and pCR patients. Furthermore, opposite trends of the treatment-induced alterations of CD8 + and CD15 + cell infiltrations were observed between pN0 and pN1 patients.ConclusionsCollectively, our data demonstrate a comprehensive picture of tumor immune landscape before and after neoadjuvant ICB combined with chemoradiotherapy in ESCC. The infiltration of CD86 + macrophage may serve as an unfavorable indicator for neoadjuvant toripalimab combined with chemoradiotherapy.

Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2.

Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical to unravel key regulatory mechanisms in host antiviral defense. Here, we leverage TurboID-based proximity labeling coupled with affinity purification-mass spectrometry to comprehensively map the proximal human proteomes of all seven canonical type I IFN signaling cascade members under basal and IFN-stimulated conditions. This uncovers a network of 103 high-confidence proteins in close proximity to the core members IFNAR1, IFNAR2, JAK1, TYK2, STAT1, STAT2, and IRF9, and validates several known constitutive protein assemblies, while also revealing novel stimulus-dependent and -independent associations between key signaling molecules. Functional screening further identifies PJA2 as a negative regulator of IFN signaling via its E3 ubiquitin ligase activity. Mechanistically, PJA2 interacts with TYK2 and JAK1, promotes their non-degradative ubiquitination, and limits the activating phosphorylation of TYK2 thereby restraining downstream STAT signaling. Our high-resolution proximal protein landscapes provide global insights into the type I IFN signaling network, and serve as a valuable resource for future exploration of its functional complexities.

Higher surface folding of the human premotor cortex is associated with better long-term learning capability

The capacity to learn enabled the human species to adapt to various challenging environmental conditions and pass important achievements on to the next generation. A growing body of research suggests links between neocortical folding properties and numerous aspects of human behavior, but their impact on enhanced human learning capacity remains unexplored. Here we leverage three training cohorts to demonstrate that higher levels of premotor cortical folding reliably predict individual long-term learning gains in a challenging new motor task, above and beyond initial performance differences. Individual folding-related predisposition to motor learning was found to be independent of cortical thickness and intracortical microstructure, but dependent on larger cortical surface area in premotor regions. We further show that learning-relevant features of cortical folding occurred in close spatial proximity to practice-induced structural brain plasticity. Our results suggest a link between neocortical surface folding and human behavioral adaptability.

HIV1-Nef perturbs the integrity of blood testis barrier in rat model

ABSTRACT The blood-testis barrier is a specialized feature within the mammalian testis, located in close proximity to the basement membrane of seminiferous tubules. This barrier serves to divide the seminiferous epithelium into distinct basal and adluminal (apical) compartments. The selectivity of the BTB to foreign particles makes it a safe haven for the virus, and the high affinity of HIV for testis might lead to the vertical transmission of the virus. In the present study, recombinant HIV1-Nef (rNef) protein was injected intravenously to examine the effect of rNef on BTB. SD male rats received 250 µg and 500 µg of rNef along with 2% Evans blue dye within 1 ml through the tail vein. After 1 hour of perfusion, the animals were sacrificed for analysis. The dye migration assay and ELISA confirmed a significant impairment in the blood-testis barrier (BTB) and the manifestation of rNef in testes tissues, respectively. Moreover, a decline in the expression of tight junction proteins, including ZO1 and Occludin, was observed during rNef-induced BTB disruption. Overall, our findings demonstrated that rNef induces BTB disruption through various signaling events. At the site of ectoplasmic specialization of the seminiferous epithelium, the localization of cadherins was found to be disrupted, making the testis a vulnerable site. In conclusion, rNef perturbs the integrity of the blood-testis barrier in rat models; hence, it can also serve as a suitable model for studying the dynamics of the blood-testis barrier.

The influence of conspecific and heterospecific neighbours on avian reproductive success

Abstract We investigated the influence of conspecific and heterospecific neighbours on the reproductive success of mountain bluebirds (Sialia currucoides) and tree swallows (Tachycineta bicolor) over eight breeding seasons. The abundance of heterospecific neighbours was negatively associated with reproductive success in mountain bluebirds but positively associated with reproductive success in tree swallows during the early nesting period (i.e., hatching rate). For bluebirds, conspecific and heterospecific neighbour abundance was associated with higher reproductive success (i.e., fledging rate) during the later stages of the nesting period; the same was true for conspecific abundance for tree swallows. These findings could be explained by either positive behavioural interactions (e.g., shared defence) or by habitat quality. We found contrasting effects of nearest neighbour distance. For both mountain bluebirds and tree swallows, having a tree swallow neighbour in close proximity was positively associated with reproductive success during the early nesting period, while having a mountain bluebird neighbour in close proximity was negatively associated with reproductive success during the late nesting period for mountain bluebirds. Together, these results indicate that the effects of conspecific and heterospecific neighbours on reproductive success are species-specific and vary depending on the phase of reproduction.

“Living the stories of your great-grandmother”: Making sense of Russia’s war in Ukraine through Polish intergenerational family storytelling

ABSTRACT After the 2022 Russian invasion of Ukraine, the Polish people were tasked with making sense of war in close proximity while supporting millions of Ukrainian refugees fleeing to Poland. In times of distress, such as war and refugee crises, intergenerational storytelling helps people make sense of their experience. Interviews with 28 Polish adults during the first five months of the war revealed that intergenerational family storytelling prompted them to: cope with war, connect with Ukraine, and help others. These narrative functions were informed by various levels of culture, as proposed by ecological systems theorizing. Findings expand communication narrative sense-making theory by accounting for sociohistorical influences in intergenerational family storytelling and highlighting how family storytelling can motivate action during crisis.

P.123 Is there an association between geographical location of patients in NS and management of unruptured, incidental intracranial aneurysm?

Background: Managing unruptured cerebral aneurysms involves monitoring or repair, with complex factors influencing decision-making. Geographical distance from treatment centers is an understudied factor. This study explores a potential relationship in Nova Scotia between proximity to the sole neurosurgical center in Halifax and aneurysm management. Methods: A prospectively collected neurosurgery database was used to identify all adults seen for unruptured cerebral aneurysm between Jan 1, 2015 - Dec 31, 2020. Demographic data, aneurysm characteristics, follow-up and treatment information were collected. Univariate and multivariate analyses assessed management differences based on geography, controlling for relevant factors including aneurysm size and location. Results: Among 390 patients, 40% were in Halifax, and 60% were outside. No significant difference existed in elective repair (34% vs. 26%, p=0.143) and imaging follow-up frequency (2.26 vs. 2.22, p=0.858). In-person follow-up was higher within Halifax (1.83 vs. 1.43, p=0.008), while virtual follow-up was significant outside Halifax (1.44 vs. 1.01, p=0.003). Overall, in-person and elective repair frequencies declined with the COVID-19 peak, whereas virtual follow-up increased. Conclusions: No significant association was found between patient location and repair decisions. Patients in closer proximity had more in-person follow-ups, while those farther away had more virtual follow-ups. The COVID-19 pandemic affected follow-up frequencies universally.

Microbial assessment of commercial pet foods marketed in the United Arab Emirates

Examining the microbiological characteristics of pet food is imperative to safeguard the health and well-being of companion animals, pet owners, and the surrounding environment. Domestic animals, known for carrying harmful microorganisms, pose a significant health risk, especially in close proximity to people and children. Notably, no studies have previously investigated pet food quality in the Gulf Cooperation Council countries, in particular, the United Arab Emirates (UAE). This study examined the microbiological quality of all stock keeping units (SKUs) of pet foods marketed in UAE (n = 118). Parameters assessed include Total Aerobic Microbial Count (TAMC), Enterobacteriaceae, Total Yeast and Mold Count (TYMC), Salmonella, Listeria monocytogenes, and Clostridium species. Among the 118 samples, 33 (28%) exceeded the acceptable TAMC limit of 106 CFU/g, highlighting significant variations based on manufacturers and ingredients. Eight samples (7%) surpassed the maximum Enterobacteriaceae limit of 3 × 102 CFU/g. TYMC levels exhibited variation, with 33 (28%) exceeding the limit of 104 CFU/g. L. monocytogenes was identified in 44 (37%) of the samples, while Salmonella was not detected. Clostridium contamination was observed in 28 (24%) of the samples. Statistical analyses revealed associations between pet food characteristics and microbial quality, underscoring the imperative for international standards to ensure the safety of pet food. These findings carry significant implications for pet owners, regulatory bodies, and the pet food industry, emphasizing the need for ongoing efforts to enhance the overall quality and safety of pet food products.

Visualization of cristae and mtDNA interactions via STED nanoscopy using a low saturation power probe

Mitochondria are crucial organelles closely associated with cellular metabolism and function. Mitochondrial DNA (mtDNA) encodes a variety of transcripts and proteins essential for cellular function. However, the interaction between the inner membrane (IM) and mtDNA remains elusive due to the limitations in spatiotemporal resolution offered by conventional microscopy and the absence of suitable in vivo probes specifically targeting the IM. Here, we have developed a novel fluorescence probe called HBmito Crimson, characterized by exceptional photostability, fluorogenicity within lipid membranes, and low saturation power. We successfully achieved over 500 frames of low-power stimulated emission depletion microscopy (STED) imaging to visualize the IM dynamics, with a spatial resolution of 40 nm. By utilizing dual-color imaging of the IM and mtDNA, it has been uncovered that mtDNA tends to habitat at mitochondrial tips or branch points, exhibiting an overall spatially uniform distribution. Notably, the dynamics of mitochondria are intricately associated with the positioning of mtDNA, and fusion consistently occurs in close proximity to mtDNA to minimize pressure during cristae remodeling. In healthy cells, >66% of the mitochondria are Class III (i.e., mitochondria >5 μm or with >12 cristae), while it dropped to <18% in ferroptosis. Mitochondrial dynamics, orchestrated by cristae remodeling, foster the even distribution of mtDNA. Conversely, in conditions of apoptosis and ferroptosis where the cristae structure is compromised, mtDNA distribution becomes irregular. These findings, achieved with unprecedented spatiotemporal resolution, reveal the intricate interplay between cristae and mtDNA and provide insights into the driving forces behind mtDNA distribution.

COVID-19 Across Professions - Infection, Hospitalisation, and ICU Patterns in a Swedish County.

To study infection, hospitalisation, and admission to ICU for COVID-19 in different occupations and pandemic waves in a Swedish county. Individual registry data of infection and hospitalisation were merged with occupational data in, this cross-sectional study. Infected, hospital- and ICU-admission were analysed by occupational groups. 22,095 cases of COVID-19 from 21 February 2021 to 31 August 2022 were identified. Healthcare workers and others working in close physical proximity showed a higher rate of confirmed COVID-19 infections in all waves and higher risk for hospital admission early in the pandemic. Exposure to diseases and physical proximity played a decisive role. Workers in close-contact occupations experienced a higher rate of confirmed infections throughout the pandemic and higher hospitalisation rates in the first pandemic wave, suggesting a need for more effective initial safety measures in a future pandemic.

Intermediate ions as indicator for local new particle formation

Abstract. Atmospheric aerosol particles have a considerable influence on climate via both aerosol–radiation and aerosol–cloud interactions. A major fraction of global aerosol particles, in terms of their number concentration, is due to atmospheric new particle formation (NPF) that involves both neutral and charged clusters and particles. NPF is the major source of atmospheric intermediate ions, i.e., charged particles with mobility diameters between approx. 2 and 7 nm. We investigate ion concentrations between 1.7 and 3.1 nm at the SMEAR II (Station for Measuring Forest Ecosystem–Atmosphere Relations II) measurement station in Hyytiälä, Finland. Both negative and positive ion number size distributions measured by a Neutral cluster and Air Ion Spectrometer (NAIS) are used. Our aim is to find the best diameter size range of ions for identifying and evaluating the intensity of local intermediate ion formation (LIIF). Intermediate ion formation (IIF) refers to the formation of intermediate ions through NPF, while local means that the growth of such ions from smaller clusters has occurred in close proximity (e.g., within 500 m to 1 km) to the measurement site, i.e., locally. We find that the ions in the mobility diameter size range of 2.0–2.3 nm are the best suited for detection of LIIF. The ion concentrations in this size range indicate the elevated rates of IIF, and the potential distances the growing ions have traveled are smaller than those for larger ions. In addition, in Hyytiälä, the negative ion concentrations are more sensitive to IIF than the positive ion concentrations due to the higher difference in concentrations between periods of IIF and the background. Therefore, we recommend the concentrations of ions with diameters 2.0–2.3 nm as the best choice for identifying and evaluating the intensity of LIIF.

Halogenation of Alkenes Using Three‐Component Reactions: A Decade of Development

Alkenes are valuable feedstocks in organic synthesis. One effective method for synthesizing organic halides with functional groups in close proximity involves the direct difunctionalization of alkenes via three‐component reactions. This approach not only reduces the number of steps involved in the synthesis process, but also minimizes waste generation and enables the formation of complex molecules from simple starting materials. In this review, we mainly discuss decade developments (2013‐2023) in two categories: (1) halogenation via three‐membered ring intermediates, involving haliranium, thiiranium, seleniranium, aziridinium and epoxide species; (2) halogenation via a radical pathway. Reactions with I2, BiI3, NaI, Bu4N+[I(O2CAr)2]‐, NIS, NBS, NCS, DBH, BsNMeBr, HBr, HCl, KI, NH4I, I2O5, Et3N·3HF, Selectfluor, CuI, CuBr, CuCl, LiCl, KBr, NaCl, SOCl2, Py·9HF, NFSI, TBSCl et al have been recorded and how the added reagents work will be discussed. We hope this review will do help for future research in this area.