Close Interaction Research Articles

New finding based on Comparative Toxicogenomics Database: Hepatic YY1 mediates drug-induced liver injury

BackgroundYY1 plays a crucial part in the onset and progression of numerous liver diseases, yet the significant contribution of YY1 to drug-induced liver injury (DILI) appears to have been underestimated by researchers. PurposeTo reveal the underlying role of YY1 in DILI. MethodThe compounds that interact with YY1 were queried in the Comparative Toxicogenomics Database (CTD), with the majority found to be hepatotoxic, which includes certain widely used drugs. Molecular docking and SPR characterized the robust binding of hepatotoxic compounds to YY1. The duty of YY1 in DILI was investigated in Diosbulbin B (DIOB), a recently identified hepatotoxic compound that tightly associates with YY1, and further validated on ANIT, LCA, APAP, and CDDP. Transcriptomic analysis disclosed the underlying mechanisms involved in DIOB-induced liver injury. RT-qPCR, immunohistochemistry, immunofluorescence, western blotting, and cellular transfection techniques were employed to validate the specific mechanism. ResultsAmong the 94 compounds affecting YY1 expression in the CTD, 59 compounds exhibited hepatotoxicity, showing close interactions with YY1 and almost consistent binding sites by molecular docking. The SPR validated the tough binding of several hepatotoxic compounds to YY1, including five FDA-approved hepatotoxic drugs. Mechanistically, the involvement of YY1 in DILI was uncovered through the cholestasis lens, mice hepatic YY1 was up-regulated by hepatotoxic DIOB and transcriptionally inhibited FXR and its downstream BSEP and MRP2 expression, initiating early in cholestatic liver injury and persisting to drive the progression of cholestasis. ANIT and LCA-induced model of cholestasis provided evidence for the hypothesis that YY1 frequently mediates drug induced cholestasis (DIC). APAP and CDDP indicated that YY1 may also be involved in hepatocellular and mixed type DILI. ConclusionYY1 widely mediated the development of DIC and also might be engaged in other types of DILI. YY1 presented a common target for hepatotoxic medications and the targeting of liver YY1 for drug development may offer a novel approach for managing DILI.

Otel çalışanlarının perspektifinden gayri ahlaki müşteri davranışları

Hotels operating for customer satisfaction experience some failures in the service delivery process. It is stated that the failures experienced may be caused by customers violating generally accepted behaviours. Jaycustomer behaviours ranging from theft to sexual harassment have severe effects on businesses, employees and other customers. This study aims to reveal various jaycustomer behaviours encountered by hospitality business employees in contact with guests and the approaches employees use to address these behaviours. In this context, semi-structured interviews were held with 12 department employees interacting with customers in five-star hotels in Kuşadası. The fact that employees working in animation, housekeeping, front office and food and beverage services departments, who have close interaction with customers, are included in the sample reflects the originality of the research. The data obtained was analysed using descriptive analysis. In this context, it has been observed that all department employees encounter jaycustomer behaviours. They commonly exhibit behaviours such as transferring information to their superiors, explaining, apologising and moving away from the environment to solve these problems. As a result of the research, essential inferences were provided to the relevant literature and hotel managers.

Characterizing the rhythmic oscillations of gut bacterial and fungal communities and their rhythmic interactions in male cynomolgus monkeys.

The rhythmic oscillation of gut microbiota can impact the physiology activity and disease susceptibility of the host. Until now, most of the studies are focused on bacterial microbes, ignoring other components of gut microbes, such as fungal microbes (mycobiota). Besides, only few studies have addressed the rhythmic correlations between gut bacteria and fungi. Here, we analyzed the rhythmic oscillations of bacterial and fungal communities in male cynomolgus monkeys by performing 16S rRNA and ITS amplicon sequencing. Apart from identifying the rhythmically oscillated bacterial and fungal microbes, we conducted the correlation analysis between these two microbial communities and found that the intestinal bacteria and fungi exhibited close interactions rhythmically, with the most interactions occurring at ZT12. Thus, our study not only investigated the rhythmic oscillations of gut bacterial and fungal communities in male cynomolgus monkeys but also uncovered their rhythmic interactions.

Nomadic and Settled Worlds: The Mutual Diffusion of Economic Institutions on the Example of the Xi Xia, Liao and Song Empires

There is a commonplace in the historical scholarship that nomadic peoples, adopting a settled way of life, borrow from the agrarian sedentary population their methods of economy managing and state administration. Chinese historical tradition tells that the nomadic periphery fell under Chinese influence and adopted from the Han people both their political and economic institutions. However, sources let us know that the situation is not so simple. There are periods of reverse influence of the nomadic world on agrarian China. In the pre-Mongolian period, the Chinese empire was at the same time at the peak of its development, stood on the threshold of the industrial revolution, but was also heavily dependent on its neighbors, being forced to pay tribute to them. Practices of regular close interaction led to diffusion, that is, the mutual borrowing of various management methods. Using the example of the Chinese Song Empire and its neighbors of the Western Xia and Liao empires, the article shows that borrowings did not always go exclusively from the Han to nomads, but, on the contrary, there was a mutual penetration of both economic and political institutions in the sphere of finance and taxation.

Challenges in laboratory testing of patients suspected of antiphospholipid syndrome: practical implications for clinicians.

This paper focuses on the laboratory tests necessary for the diagnosis of antiphospholipid syndrome (APS). Diagnosis starts with the selection of patients suspicious of having APS. The timing related to the clinical event is important to avoid false classification of APS patients. For the interpretation of the test results of antiphospholipid antibodies (aPL) understanding of all pitfalls and interferences is necessary. Lupus anticoagulant (LA) measurement remains a complex procedure with many pitfalls and interferences. The effect of anticoagulant therapy, the main confounder of LA measurement, can be overcome by removal agents for direct oral anticoagulants (DOAC) or by considering assays as Taipan snake venom time / Ecarin clotting time not affected by antivitamin K therapy and anti-Xa DOAC. However, both procedures have limitations. Solid-phase assays for anticardiolipin antibodies (aCL) and anti-β2-glycoprotein 1 antibodies (aβ2GPI) show inter-assay differences. Diagnosis is based on the measurement of three groups of aPL: LA, aCL and aβ2GPI, of IgG and IgM isotype. This allows to make antibody profiles that helps in identifying patients at risk. Other aPL, such as antibodies against the domain I of β2GPI and anti-phosphatidylserine-prothrombin antibodies may be useful in risk stratification of APS patients and in some specific situations of patients with incomplete antibody profile, but are not needed for diagnosis. Laboratory diagnosis of APS remains challenging. To increase the diagnostic efficacy and reliability, an integrated interpretation of all results and an interpretative comment should be provided on the laboratory report. Therefore, a close interaction between clinical pathologists and clinicians is mandatory.

Destigmatizing borderline personality disorder with social justice and intersectional cultural humility: How researchers can construct and deconstruct stigma

Borderline personality disorder (BPD) is a serious psychiatric condition, especially stigmatized in women. Stigma is a social injustice, as it discredits and reduces the wholeness of a person to one of taint and discount. Psychological scientists play a uniquely powerful role in the stigmatization and destigmatization of BPD by constructing the meaning of BPD at each step of the research process. We discuss this powerful role and how to destigmatize BPD by incorporating an intersectionality framework that includes disability as a category of difference (as with gender, race, and sexuality). This framework centers the role of systems and structures in creating and maintaining stigma, while emphasizing the close interactions between interpersonal and structural stigma. This article illustrates researchers’ power to assign meaning to BPD in research and highlights the importance of considering individuals as embedded in intersectional social categories, which are multidimensional and dynamic in nature. We propose that intersectional cultural humility, with its social justice aim and feminist origins, can guide BPD researchers to conduct nonstigmatizing and rigorous research on BPD. To inform clinical practice and advance social justice, we offer action steps for researchers to destigmatize BPD with intersectional cultural humility at multiple steps in the research process.

Tactile and kinesthetic communication glove with fusion of triboelectric sensing and pneumatic actuation

Dexterous manipulation of hand plays a crucial role in daily life, industrial productivity, and research laboratory, etc. Evolution of humanoid robot and virtual training technique raise the demand of human machine interface with fusion of both sensing and feedback functions to realize the close loop interactions. Here, we present a modular glove which combines triboelectric sensor and pneumatic actuator for enabling multi-modal and multi-dimensional sensing and feedback. Owing to commonalities of materials and structural design, pneumatic actuator and triboelectric sensor can be seamlessly merged. The integration of fingertip module and finger module offers cutaneous and kinesthetic feedback with the corresponding sensing functions. The whole glove can perform sensing and actuation for most of the interactive activities, such as touching, twisting, grabbing, rubbing, etc. With the customized wearable signal processing and control system, the robotic hand manipulation and virtual training program were demonstrated to verify the capabilities of improving the tactile perception in different scenarios. In general, the proposed device with a minimalistic design and multi-modal sensing and feedback can improve the issue of missing or mismatch of tactile communication in robotic teleoperation, virtual training, and rehabilitation.

Ultrathin 2D/2D MoS2/Bi2WO6 S-scheme heterojunction for boosting photocatalytic degradation of ciprofloxacin

A series of 2D/2D MoS2/Bi2WO6 S-scheme heterojunctions consisting of ultrathin MoS2 nanosheets (MS, 1.6 nm) and ultrathin Bi2WO6 nanosheets (BWO, 1.5 nm) were developed for photocatalytic degradation of ciprofloxacin. The samples with 5 % mass ratio of MS (5 %MS/BWO) exhibits the almost complete degradation of ciprofloxacin (≈100 %) under visible light. It is evidenced that the formation of S-scheme heterojunction with close interfacial interaction facilitates the photoinduced carrier separation and the generation of surface acid sites. The activation of ciprofloxacin molecules is realized through the coordinately interaction of C-N and C=O with the surface W sites. Moreover, the OVs in BWO side is a convenient pathway for activated of O2, embodying in the generation of •O2− and •OH under visible light over photocatalyst. Such an association of charge transfer mechanism with coordination activation shows the enhanced photocatalytic performance toward ciprofloxacin. This work provides a motivation which designs an S-scheme heterojunction photocatalyst with the ability to activate the specific group in molecules to comprehend the degradation of antibiotics.

Profiles and interactions of gut microbiome and intestinal microRNAs in pediatric Crohn's disease.

Since previous studies have focused on the change of the fecal gut microbiome and intestinal tissue miRNA in pediatric Crohn's disease (CD), the relationship between them in different stages is still not clear. This is the first study to explore the gut microbiota and miRNA and their correlations with the Pediatric Crohn's Disease Activity Index (PCDAI). Crohn's Disease Endoscopic Index of Severity (CDEIS), and calprotectin, by applying two omics approach in three different groups (active CD, CD in remission with exclusive enteral nutrition or infliximab induction therapy, and the healthy controls). Both gut microbiome structure and the miRNA profiles were significantly changed in the different stage of CD. Seven key gut microbiome at species and eight key miRNAs were found, and their close interactions were further fully investigated by miRNA target prediction.

Demographic and zoological drivers of infectome diversity in companion cats with ascites.

Frequent studies reported the risks of cats as an intermediate host of zoonotic pathogens (e.g., SARS-CoV-2). Cats have a physically close interaction with their owners through activities like petting, kissing, and being licked on the cheek and hands. However, there are still limited studies that systematically investigate the infectome structure of cats. In this study, we employed a meta-transcriptomics approach to characterize 15 species of pathogens in cats, with Candidatus Rickettsia tarasevichiae first characterizing infection in diseased cats. Most feline diseases were better explained by the presence of virus-bacteria or virus-virus coinfection. The increase in infectome diversity could be influenced by a variety of predictors including age growth, temperature increase, and a higher proportion of females. A higher diversity of pathogens was harbored in young cats rather than adults. Importantly, we showed the value of linking the modern influx of meta-transcriptomics with comparative ecology and demography and of utilizing it to affirm that ecological and demographic variations impact the total infectome.

Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder.

Background/Objectives: Attention deficit hyperactivity disorder (ADHD) is the most common childhood-onset neurodevelopmental disorder, characterized by difficulty maintaining attention, impulsivity, and hyperactivity. While the cause of this disorder is still unclear, recent studies have stated that heredity is important in the development of ADHD. This is linked to a few comorbidities, including depression, criminal behavior, and anxiety. Although genetic factors influence ADHD symptoms, there are also non-genetic factors, one of which is oxidative stress (OS), which plays a role in the pathogenesis and symptoms of ADHD. This review aims to explore the role of OS in ADHD and its connection to antioxidant enzyme levels, as well as the gut-brain axis (GBA), focusing on diet and its influence on ADHD symptoms, particularly in adults with comorbid conditions. Methods: The literature search included the main available databases (e.g., Science Direct, PubMed, and Google Scholar). Articles in the English language were taken into consideration and our screening was conducted based on several words such as "ADHD", "oxidative stress", "diet", "gut-brain axis", and "gut microbiota." The review focused on studies examining the link between oxidative stress and ADHD, the role of the gut-brain axis, and the potential impact of dietary interventions. Results: Oxidative stress plays a critical role in the development and manifestation of ADHD symptoms. Studies have shown that individuals with ADHD exhibit reduced levels of key antioxidant enzymes, including glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), as well as a diminished total antioxidant status (TOS) compared to healthy controls. Additionally, there is evidence of a close bidirectional interaction between the nervous system and gut microbiota, mediated by the gut-brain axis. This relationship suggests that dietary interventions targeting gut health may influence ADHD symptoms and related comorbidities. Conclusions: Oxidative stress and the gut-brain axis are key factors in the pathogenesis of ADHD, particularly in adults with comorbid conditions. A better understanding of these mechanisms could lead to more targeted treatments, including dietary interventions, to mitigate ADHD symptoms. Further research is required to explore the therapeutic potential of modulating oxidative stress and gut microbiota in the management of ADHD.

Domesticating Human Capital

This article investigates the consumption of knowledge in early modern Amsterdam. A dataset of seventeenth- and eighteenth-century probate inventories is employed to examine the synergies and inequalities between the skilled and educated middle classes and the intellectual elites. A series of democratisation waves in the ownership of books, writing equipment, and measuring tools confirms the unprecedented levels of basic literacy and numeracy skills in the urban centres of the early modern Low Countries revealed by research on signature proficiency and age heaping. The concentration of secular books and advanced knowledge objects in the hands of a small but growing group of affluent households, on the other hand, corresponds to other research that has fixated instead on the role of upper-tail human capital in scientific, technological, and economic progress. Yet, the relatively low value estimates of libraries and scientific instruments, together with a more qualitative examination of two amateur scientists of middling background, dovetails with the hypothesis that the Dutch Scientific Revolution and Enlightenment were marked by a close interaction and mobility between craftsmen and scientists. An above-average income and enough leisure time to develop intellectual interests could be sufficient for inhabitants of Amsterdam to cross the Rubicon from consuming to (re)producing knowledge.

Nuclear Magnetic Resonance Treatment Induces ßNGF Release from Schwann Cells and Enhances the Neurite Growth of Dorsal Root Ganglion Neurons In Vitro.

Peripheral nerve regeneration depends on close interaction between neurons and Schwann cells (SCs). After nerve injury, SCs produce growth factors and cytokines that are crucial for axon re-growth. Previous studies revealed the supernatant of SCs exposed to nuclear magnetic resonance therapy (NMRT) treatment to increase survival and neurite formation of rat dorsal root ganglion (DRG) neurons in vitro. The aim of this study was to identify factors involved in transferring the observed NMRT-induced effects to SCs and consequently to DRG neurons. Conditioned media of NMRT-treated (CM NMRT) and untreated SCs (CM CTRL) were tested by beta-nerve growth factor (ßNGF) ELISA and multiplex cytokine panels to profile secreted factors. The expression of nociceptive transient receptor potential vanilloid 1 (TRPV1) channels was assessed and the intracellular calcium response in DRG neurons to high-potassium solution, capsaicin or adenosine triphosphate was measured mimicking noxious stimuli. NMRT induced the secretion of ßNGF and pro-regenerative-signaling factors. Blocking antibody experiments confirmed ßNGF as the main factor responsible for neurotrophic/neuritogenic effects of CM NMRT. The TRPV1 expression or sensitivity to specific stimuli was not altered, whereas the viability of cultured DRG neurons was increased. Positive effects of CM NMRT supernatant on DRG neurons are primarily mediated by increased ßNGF levels.

Anti-hypertensive medications and erectile dysfunction: focus on β-blockers.

Although anti-hypertensive medications, including thiazides and β-blockers (BBs) in particular, have been suggested to cause erectile dysfunction (ED) their real contribution is still conflicting. The aim of this paper is to summarize available evidence providing an evidence-based critical analysis of the topic. An overall comprehensive narrative review was performed using Medline, Embase and Cochrane search. In addition, to better understand the impact of BBs on ED a specific systematic review was also performed. The negative role of centrally acting drugs, such as clonidine and α-methyldopa, is well documented althuogh limited controlled trials are available. Angiotensin-converting enzyme inhibitors (ACEis), angiotensin receptor blockers (ARBs), and calcium-channel-blockers (CCBs) have neutral (CCBs) or even positive (ACEis and ARBs) effects on erectile function. Despite some preliminary negative reports, more recent evidence does not confirm the negative impact of thiazides. BBs should be still considered the class of medications more often associated with ED, although better outcomes can be drawn with nebivolol. Sexual function should be assessed in all patients with arterial hypertension, either at diagnosis or after the prescription of specific medications. A close related patient-physician interaction and discussion can overcome possible negative outcomes allowing a successful management of possible side effects.

Study of the static response and zoning of the existing tunnel adjacent to the suspension bridge's tunnel-type anchorage

Due to the ability to utilize the strength of the surrounding rock to enhance bearing capacity, tunnel-type anchorages have been consistently utilized in suspension bridges. Nevertheless, a close interaction occurs between the tunnel and the tunnel-type anchor when a highway tunnel is connected to a suspension bridge. This study employed numerical simulation and theoretical analysis based on the G317 Line Huangjiayuan tunnel and Zipingpu Bridge tunnel-type anchorage project, focusing on this specific type of adjacent engineering. Firstly, the discriminant degree of adjacent influence suitable for the interaction between the tunnel-type anchorage and the tunnel structure is established. The calculation conditions are distinguished by the influencing factors determined in the discriminant. The interaction law between tunnel-type anchorage and pre-built tunnel structure is further obtained. Using the method of curve regression, based on the criterion of proximity influence degree, the partition of mutual influence degree between the tunnel-type anchorage and the tunnel structure is obtained. At the same time, it is concluded that under the original design condition, the displacement degree of the tunnel structure will be greatly affected, and the tunnel structure is located in the strong influence area. According to the partition result, under the benchmark engineering geological condition, it is suggested that the angle of intersection between tunnel anchorage and tunnel structure should be increased to 3.3° and the anchor body inclination should be increased to 44°.

Ready or not…here we grow! Evaluating the competency of nursing faculty in supporting nursing student mental health: A quantitative investigation

BackgroundCollege students are amid a mental health crisis with campuses seeing the highest rates of mental health disorders in over a decade. College nursing students stand out as particularly affected, experiencing elevated levels of anxiety, stress, and depression compared to the general student population. At the forefront of addressing this issue are college faculty, especially nursing faculty, who play a unique role in identifying and referring students with mental health needs due to their close interactions in smaller teaching-learning settings such as clinicals, simulations, and one-on-one validations. AimThis study evaluated the perceived competency, knowledge, engagement, and fear levels of nursing faculty in supporting the mental health of Bachelor of Science in Nursing students. Additionally, the study explored whether faculty members with prior MH training differed in these levels. MethodsSurvey data from 63 faculty members employed across six prominent nursing schools in the southeast region of the United States, all offering Bachelor of Science in Nursing programs, were analyzed. Employing a cross-sectional design, the study utilized the “College Mental Health Perceived Competency Scale” (CMHPCS) to assess faculty's competence, knowledge, engagement and fear in supporting student mental health. ResultsAmong the 63 participants, significant differences were observed in engagement levels between nursing faculty with and without prior mental health training (p < .012). Overall, the surveyed nursing faculty demonstrated high levels of competence, engagement and knowledge and low levels of fear in supporting the nursing student's mental health. ConclusionThe results prompt recommendations for future research aimed at developing a comprehensive approach to equip nursing faculty with effective mental health training and interventions. Such efforts seek to empower student nurses with the tools necessary to support their own mental health, enabling them to competently care for patients and communities.

Kollegialitet i den videregående skolen: Lektoridentitet i en skoleorganisasjon i endring 1960–2010

Collegiality in upper-secondary school: Teacher identity in a changing school organization (1960–2010). In this article, it is argued that the teachers at the Norwegian upper secondary school had a distinct collegial practice characterised by both formal and informal aspects of collegiality, as well as close interaction between institutional and disciplinary bodies at the school. This practice enabled the teachers to be involved in their own academic and professional development, as well as in the governance of the school. With the democratisation of the school in the 1960s and 70s, and with the new ideals of governance in the 1990s, the characteristics of the teachers’ collegial culture were seen as a hindrance rather than a resource in the development of the school and the teaching profession. Drawing on unique sources from school archives, the article examines the teachers’ collegiality and how it changed from 1960 to 2010.

Monkeypox: A Growing Global Health Challenge and the Need for Vigilant Preparedness

The Ongoing Public Health Challenge of Monkeypox Monkeypox is relatively a new threat to the global community as it has brought into focus the issue of improved surveillance and response to infectious diseases[1]. Initially, a rather exotic zoonotic pathogen limited to certain regions of Central and West Africa, monkeypox is being detected in the countries that previously did not report its occurrence, which creates new challenges for the health care systems of the world[2]. Understanding the Disease Monkeypox is an infectious disease that results from the attack of monkeypox virus which is in the Ortho poxvirus group of the virus family Poxviridae though the smallpox virus has been eradicated. The disease has some symptoms are similar to smallpox and includes fever, body aches, and rash that goes through different stages. Despite the fact that monkeypox is less severe when compared with smallpox, significant morbidity and potentially mortality cannot be ruled out[3]. Direct human-to-human transmission is by contact with infected body fluids, aerosols, or fomites such as used clothing, beddings among others. Recent epidemics have been experienced in the urban areas as this makes it easier for the virus to spread due to high population densities. This has transformed the disease from one which affected isolated African communities to a problem in developed, globally connected cities[4]. Why Should We Be Concerned? The stoppage of smallpox vaccination has exposed the people to Ortho poxviruses such as monkeypox. The constant risk of getting zoonotic diseases due to factors such as deforestation, urbanization and close interaction with animals means that diseases, which are mainly associated with animals, can easily infect human beings. Furthermore, the flexibility in the global interconnectivity of today’s world through travel and business has facilitated the spread of the virus across the borders. In 2022, 34 monkeypox cases were reported in European countries, the Americas, and other areas of the world, where the disease had not been identified[5, 6]. The Public Health Response To this recent outbreak of the disease, the WHO and the CDC have scaled up awareness campaigns and encouraged surveillance as well as put in place measures to contain the spread of the disease. Mass vaccination campaigns using smallpox vaccines that work against monkeypox have been intensified in the affected countries, however, there are several problems with implementing this approach: the difficulties of delivering vaccines in time and the scarcity of the vaccines themselves[7]. These are important in educating communities on how to avoid the disease and this include avoiding contact with sick persons, washing hands regularly and consulting a doctor when experiencing early symptoms of the disease. It also means that health systems need to be ready and able to identify such patients and isolate them to avoid spreading of the virus[8, 9]. Looking Forward The spread of monkeypox in the non-endemic countries is a cause of concern and questions the efficiency of our societies’ prevention, detection, and controlling of infectious diseases. Even as the current outbreaks have informed the world of the virus, it is important to note that this is not a one-off case[10]. Zoonotic diseases, which can be transmitted from animals to people, will remain a threat into the future as people increase in numbers and expand their living space into the domain of wildlife. The fight against monkeypox is the fight against all other infectious diseases that can be most effectively fought for with a proper approach and mutual cooperation of all countries[11]. Monkeypox is not as dangerous as some other infectious diseases but looking at the example of how this disease affected people one can conclude that public health cannot be unguarded. Prevention of such diseases in the future would require increased investment in the global health care system, outcome of research on new diseases and vaccination exercises. We cannot afford to wait for another pandemic to happen in order to start acting[12, 13].

Biomedical Metal–Organic framework materials on antimicrobial therapy: Perspectives and challenges

As a barrier between the structure of the human body's internal organs and the outside environment, the skin serves crucial physiological tasks like protection, regulation, and metabolism. The skin's close interaction with the outside makes it particularly vulnerable to many injuries. Bacterial infections cause wound healing to take longer, raise the risk of chronic harm, and serve as a breeding ground for drug-resistant bacteria. As a result, it is critical to eliminate bacterial species from the wound region rapidly and efficiently. Metal-organic frameworks (MOFs), are critically adjustable hybrid materials that integrate organic ligands with coordination metals to generate a range of topologically isomorphic structures. MOFs' creation and shape are investigated by the metal source and ligand utilized in the reaction process, and the structural benefits of this near-infinite combination of structures allow boundless potential for their surface functionalization. MOF has a large effective surface area, tunable structure, adaptability, excellent biodegradability, high drug load, adjustable release of drugs, robust targeting, etc. It can be loaded with therapeutic materials and has programmability. It is more conducive to treating complex wounds while realizing the synergistic effects of antibacterial, anti-inflammatory, and pro-angiogenesis, effectively improving treatment safety. This review summarizes the most recent research advances on various MOFs for antimicrobial therapy, using diverse types of metal-ion-based MOFs as an entry point. Finally, it covers several important challenges in the antimicrobial treatment of metal-ion-based MOFs.

Social Changes in the community After 24-Hour Electricity in Temajuk Village, Paloh District, Sambas Regency

This study aims to find out and describe the social changes in the community in Temajuk Village after the existence of 24-hour electricity from the social, economic, and cultural aspects. The theory used in this study is the Theory of the Dimension of Social Change (Himes and Moore). The method used in this study is qualitative research with a descriptive approach. The data collection technique uses observation, interview, and documentation techniques. The informants of this research were determined using the purposive sampling technique according to the criteria that had been determined, namely inn owners, homemakers who sell online, the general public, village heads, village officials, and PLN technical supervisors. The data analysis technique used is an analysis model from Miles and Huberman that goes through three stages: data reduction, data presentation, and conclusion. The results of this study are, first, the structural dimension related to the economic aspects of the community. There is a change in the role/emergence of a new role for homemakers to become online traders and changes in access to the activities of inn owners by utilizing 24-hour electricity facilitated by PT PLN to increase income. Both dimensions relate to cultural changes in children's language and habits. The use of language from social media began to grow, and traditional game habits began to be abandoned. The three interactional dimensions are related to social aspects, namely community interaction, which is the reduction of interaction intimacy in the family and the closer interaction between communities in Temajuk Village.