Close Family Contacts Research Articles

Prophylaxis of varicella in children with neoplastic disease: Comparative results with zoster immune plasma and gamma globulin

The incidence and severity of varicella following a close family contact were evaluated in children with neoplastic diseases who received prophylaxis either with commerical gamma globulin or with zoster immune plasma, as compared to patients who did not receive any prophylaxis. In the untreated group, all 14 patients developed varicella, complicated by 1 case of encephalitis and 2 cases of fatal pneumonia. In the group of 17 patients who received 0.6-1.2 ml/kg body weight of gamma globulin, 16 developed varicella, complicated by pneumonia in 2 cases, with 1 death. In the third group of 27 patients who received 10 ml/kg body weight of zoster immune plasma (ZIP), obtained from healthy adults convalescing from herpes zoster, there were only 8 cases of varicella, all very mild. Thus, prophylaxis with ZIP significantly reduced the incidence of clinical varicella (p less than 0.01) and attenuated the severity of its course.

Conjunctivitis and subclinical infection in smallpox.

SUMMARYAttempts were made to demonstrate variola virus in the conjunctival exudate of 84 smallpox patients who developed conjunctivitis in the acute stage of the illness or during convalescence. Variola virus was isolated from 60 but not from the remaining 24. Of the 64 from whom virus was isolated the conjunctivitis developed from the onset up to the 15th day of illness. From conjunctivitis developing later virus was not recovered. In some patients who developed conjunctivitis early in the disease we failed to recover virus from the conjunctival exudate.Of 55 close family contacts who stayed in hospital with smallpox patients four developed smallpox. In 21, conjunctivitis but no other illness developed. From 12 of these, variola virus was recovered from the conjunctival exudate and four of these 12, who were further investigated, showed after the appearance of conjunctivitis antibody titres similar to those seen in typical smallpox cases. From nine of the contacts who developed conjunctivitis virus was not recovered. One of these had antibody titres in serum collected before the onset of conjunctivitis which indicated recent smallpox infection. In another there was a marked antibody rise during her hospital stay although examination of conjunctival exudate on three separate occasions failed to yield variola virus. Twenty-six family contacts who developed no illness in hospital had antibody determinations made on sera collected soon after admission to hospital. In eight of these antibody titres were such as to indicate recent smallpox infection although there were no signs, in the form of scarring, or history of recent smallpox infection. These findings have been discussed in relation to the occurrence of minimal and subclinical infection in close family contacts of smallpox patients.This investigation was supported in part by Public Health Service Grant AI–1632–16 VR from the National Institute of Allergy and Infectious Diseases, by the World Health Organization and by the Marcus T. Reynolds III Fund.

Prevalence of Tuberculin Sensitivity in the Panama Canal Zone

1. The tuberculin tests were completed on 87.7 per cent of the total pupil enrollment in the U. S. schools, and on 84.3 per cent of the total enrollment in the Latin-American schools on the Canal Zone. 2. The prevalence of infection among the U. S. students was lower and the data suggest the possible minimal risk of infection through family and community infection. 3. The prevalence of infection among the Latin-American students was higher than the U. S. students, but much lower than the same age groups in the terminal cities of Panama and Colon, demonstrating the high community risk of infection through close family and community contacts in these cities.

415. Prevalence of tuberculosis among close family contacts of tuberculosis patients in South India, and influence of segregation of the patient on the early attack rate.

415. Prevalence of tuberculosis among close family contacts of tuberculosis patients in South India, and influence of segregation of the patient on the early attack rate.