Frequency-comb-based optical two-way time and frequency transfer (O-TWTFT) can support future ultra-precise clock networks over free-space links. However, demonstrations have thus far only operated at one corner of a complex parameter space, which balances received optical power, timing performance, and update rate. Here, we analyze the performance of O-TWTFT across this parameter space, with a specific focus on extending the link distance at constant launch power and telescope aperture. We perform experiments across a three-node network spanning 28 km of turbulent air, and successfully demonstrate a more than 2000\ifmmode\times\else\texttimes\fi{} reduction in the required received optical power corresponding to a potential 45\ifmmode\times\else\texttimes\fi{} increase in distance. This distance increase does come with an associated reduction in timing precision, with the uncertainty increasing from 60 as to 20 fs at 10 s averaging times. However, this level of precision is still more than adequate for most applications. In addition, it comes with a reduction in sampling rate, which potentially limits this approach to static links. Interestingly, because this system optimization does not require any hardware modifications, O-TWTFT links could be dynamically tuned to support future long-distance optical clock networks over a range of conditions and applications.