Clinical Signs Of Neurologic Disease Research Articles

Combined Cystometric, Sphincter Electromyographic and Uroflowmetric Studies Before and After Transurethral Resection of the Prostate

Detrusor and urethral function was studied in 10 patients before and 3 months after transurethral resection of the prostate by means of flowmetry, and simultaneous gas cystometry and integrated sphincter electromyography. The patients had no clinical signs of neurological disease. Six had neurogenic exaggeration of the detrusor reflex in the preoperative studies. In 3 patients changes in the detrusor reflex were found postoperatively. Postural changes in detrusor reflex excitability were encountered preoperatively and postoperatively. The preoperative finding of detrusor hyperreflexia in the majority of the patients is ascribed to lesions in the detrusor reflex organization at 2 anatomical sites: 1) a subclinical lesion of the cerebral circuits of the detrusor reflex control owing to arteriosclerosis and 2) an increase of sensory detrusor-reflex triggering stimuli from the morphologically changed prostatic urethra. The study calls for diagnostic techniques for delineation of minimal cerebrospinal impairment and objective assessment of the sensory innervation of the urethra.

Neurologic disease in wapiti naturally infected with meningeal worms.

Four wapiti (Cervus canadensis) from Oklahoma which had shown clinical signs of neurologic disease were submitted for pathological examination. Both mature female and larval meningeal worms (Parelaphostrongylus tenuis Pryadko and Boev, 1971) were either observed in or recovered from the meninges and parenchyma of the brains. Lesions found in the brain of each wapiti included focal meningitis, perivascular cuffing, and focal gliosis; frequently these were associated with the meningeal worms. There appeared to be a direct correlation between the presence of meningeal worms and lesions observed histologically which resulted in neurologic disturbances in the wapiti.

Cerebral nematodiasis in a red squirrel.

Necropsy of a South American red squirrel (Sciurus granatensis), with clinical signs of neurological disease, disclosed multifocal parasitic granulomata in the brain, lung and myocardium. Lesions were noted in the cerebral hemispheres and subcerebellar white matter. The parasite was identified as a larval ascarid. History of close contact with excreta from raccoons suggested the larvae were that of Ascaris columnaris, an intestinal nematode of the raccoon.