SERUM PROTEINOGRAM IN COPPER-POISONED SHEEP Sheep have a tendency to accumulate copper in the body. When the liver storage capacity is exhausted, there is a sudden release of the accumulated copper into the blood causing clinical signs of poisoning. This study investigates the changes in serum proteins during pre-hemolytic and hemolytic phases of chronic copper poisoning. A total of 6 lambs were randomly divided into two groups: control group (Group 1); and experimental group (Group 2). In addition to the daily diet, animals from the second group received 3mg of CuSO4 5H2O/Kg LW per day during the first week, after which it was increased at weekly intervals. Blood biochemical components were assessed at various times: M0, M1, M2, M3, M4, M5 and M6. Serum analysis revealed reduction of ceruloplasmin levels, whereas transferrin levels, the 35,000 Da protein, and IgG light chains increased in M2.