Clinical Practice Research Research Articles

Development and Clinical Validation of Model-Informed Precision Dosing for Everolimus in Liver Transplant Recipients.

Everolimus presents significant dosing challenges due to between- and within-patient pharmacokinetic variabilities. This study aimed to develop and validate a model-informed precision dosing strategy for everolimus in liver transplant recipients. The dosing strategy was initially developed using retrospective data, employing nonlinear mixed-effects modeling. The model included readily measurable covariates, body surface area, albumin, and tacrolimus trough concentration. The dosing strategy was subsequently validated in a prospective trial, recommending 1 to 1.75 mg dosages every 12 h, depending on covariates. Lower dosages were recommended for patients with lower body surface area and albumin with adjustments based on tacrolimus trough concentration. The estimated pharmacokinetic parameters (typical value ± standard error), apparent clearance (CL/F: 15.0 ± 0.5 L/h), and apparent volume of distribution (Vd/F: 862 ± 79.3 L) were refined using prospective clinical data from 20 patients, reducing interindividual variations. This research successfully developed and validated a population pharmacokinetic model for everolimus. The developed "dosE" web-based platform translates our pharmacokinetic model into a practical tool for healthcare providers, exemplifying the application of pharmaceutical research in clinical practice and potentially improving therapeutic outcomes in liver transplantation.

Thrombosis, Translational Medicine, and Biomarker Research: Moving the Needle.

Arterial and venous thromboembolism are leading causes of morbidity and death worldwide. Despite significant advances in the diagnosis, prognostication, and treatment of thrombotic diseases over the past 3 decades, the adoption of findings stemming from translational biomarker research in clinical practice remains limited. Biomarkers provide an opportunity to enhance our understanding of pathophysiological processes and optimize treatment strategies. They hold the promise of revolutionizing patient care. Still, this potential remains untapped, and several factors impede their use for near-patient applications. We sought to provide an overview of biomarker research in arterial and venous thromboembolic disease. We then aimed to discuss key barriers to the broader clinical implementation of biomarker research and highlight promising strategies to overcome them. We emphasize the merits of translational and implementation science to bridge the gaps from bench to bedside. Innovative trial design, data sharing, and collaborative efforts between academia and industry will be essential. Purposeful regression methodology using rational conceptual framework design, causal mediation analysis, and artificial intelligence might better leverage the use of observational data. Dedicated translational science training programs geared toward educating physicians on the appropriate measurement, interpretation, and integration of biomarker data in clinical practice should foster endorsement by frontline physicians. Finally, we make the case in support of a paradigm shift in cardiovascular medicine. Improved recognition of biomarker research and a greater emphasis on mechanistic evidence can better equip clinicians to deal with the uncertainty that defines the practice of thrombosis medicine.

Exploration of attitudes towards research: Operating department practitioners and theatre nurses.

A lack of awareness of who should conduct research, conflicting workload priorities, lack of research skills, lack of confidence and lack of supportive relationships are often cited as barriers for undertaking research within the perioperative environment. Building a robust research capacity for Operating Department Practitioners and Theatre Nurses to engage with and lead primary research is critical to develop perioperative clinical outcomes, and for professional and research excellence. This study aimed to explore the attitudes of Operating Department Practitioners and Theatre Nurses towards research. An online questionnaire was distributed nationally between 1 October 2022 and 31 December 2022. The questionnaire received 164 responses from 114 Operating Department Practitioners, 44 Theatre Nurses and 6 respondents identifying as other. These revealed that those with a positive attitude towards research were most likely to have obtained a Master's level qualification (i.e. MSc) and had gained experience in research post-registration. When explored further, the overall positive attitude to research was found to be possibly linked to a belief in the usefulness of research and to prior exposure. The findings of this study can be used to help support, inform and strengthen research in clinical practice and research career aspirations. Analysis of the data suggests that participants holding a Master of Science degree and having previous experience of research reported a more positive attitude to research. When the specific attitudes to research were explored individually, there was also some evidence that the overall positive attitude to research was more likely to be related to a belief in the usefulness of research.

Embedding a culture of research in Canadian community hospitals: a qualitative study

BackgroundIn Canada, academic hospitals are the principal drivers of research and medical education, while community hospitals provide patient care to a majority of the population. Benefits of increasing community hospital research include improved patient outcomes and access to research, enhanced staff satisfaction and retention and increased research efficiency and generalizability. While the resources required to build Canadian community hospital research capacity have been identified, strategies for strengthening organizational research culture in these settings are not well defined. This study aimed to understand how research culture is experienced and shaped in Canadian community hospitals to provide strategies for strengthening research culture in these settings.MethodsThis qualitative descriptive study, as part of a larger study, explored the underlying dimensions of research culture. Participants were purposefully sampled and included healthcare providers, research staff or hospital administrators from community hospitals across Canada, with non-existent, emerging or established research programs. Data were collected via virtual semi-structured interviews and a demographic questionnaire. Interview transcripts were analyzed using reflexive thematic analysis and Schein’s Model of Organizational Culture as a sensitizing framework. Demographic data were analyzed using descriptive statistics.ResultsA total of 38 participants from 20 Canadian community hospitals described their experiences of research culture illustrating three key themes. As community hospital research programs matured, participants described a shift in research culture whereby research became more embedded in “the way things are done” within the community hospital. Recommended strategies to achieve an embedded culture of research involve: communications; relationship building; mentorship, training and education opportunities; selecting locally relevant studies; and systems-level support. A top-down approach to embedding research culture was contrasted with a bottom-up approach.ConclusionsThis study described the underlying dimensions of community hospital research culture and targeted strategies for strengthening research culture at different levels of research program maturity. Community hospitals without pre-existing research infrastructure were able to foster a culture of research from the bottom-up by emphasizing the value of embedding research in clinical practice. Although challenging, fostering a culture of research from the bottom-up may be necessary to propel research forward and initiate the process to build research capacity within a community hospital.

Results of a Multicenter Clinical Study on Adaptation and Validation of the Russian Version of the Clinical Assessment Interview for Negative Symptoms (CAINS)

The aim of the study is to adapt and validate the Russian version of the Clinical Assessment Interview for Negative Symptoms (CAINS).Material and methods. From 2018 to 2024, 89 people were examined: 42 men (47.2%) and 47 women (52.8%), average age 37±9.8 years. Among them, 82 patients (92.1%) were diagnosed with F20.0 according to ICD-10, 5 patients (5.6%) with F21, and 2 patients (2.3%) with F23.1. The mean duration of the mental disorder was 18 [1-42] years, with an average number of hospitalizations of 12 [1-28] times. The CAINS manual and questionnaire text, translated into Russian by a group of young psychiatrists from the RSP YPC, were utilized for assessment.Results: The Cronbach’s alpha for the total score of the questionnaire was 0.91. Convergent validity was demonstrated by a significant positive correlation between CAINS scores and the Marder PANSS factor. Confirmatory factor analysis indicated the preservation of the questionnaire’s two-factor model, explaining 55.8% of the total variance. Discriminant validity was evidenced by the more frequent absence of correlations between CAINS scores and positive and general psychopathological PANSS ratings. Inter-rater reliability was established by a sufficient level of agreement, with Cohen’s kappa coefficient, among independent raters for the majority (91%) of clinical assessments using the CAINS questionnaire.Conclusion: The obtained results demonstrate that the Russian adaptation of the Clinical Assessment Interview for Negative Symptoms (CAINS) is a valid and effective psychometric clinical interview. It can be utilized for both clinical research and everyday clinical practice when working with patients suffering from psychotic disorders within the schizophrenia spectrum.

Editorial: Best practices in clinical research conduct in veterinary medicine

Editorial: Best practices in clinical research conduct in veterinary medicine

Clinical Research Practitioner: Transformation to a Competent Professional Through Reflective Practice.

The National Institute for Health and Care Research (NIHR) has significantly contributed to the growth of clinical research activities in the United Kingdom. Central to this expansion is the pivotal role of Clinical Research Practitioners (CRPs) within the healthcare organization. This narrative explores reflective practice as a dynamic tool and essential requirements for their transformation and development into competent CRPs. Additionally, this article adds to the growing literature to highlight the benefits of having a professionally registered CRP for NHS organizations. By weaving together personal insights, professional development, and the integration of acquired knowledge, the narrative illuminates the profound impact of reflective practice on the evolution of a skilled and adept CRP. This review adds to the current literature on the importance of reflective practice in improving professionalism and competency for registered CRPs. The narrative emphasizes lifelong learning and reflective practice integration in clinical research training programs. It suggests further research on workplace reflection for knowledge integration. This resource is valuable for CRPs, organizations, and policymakers, emphasizing professionalism, competency development, and reflective practice in clinical research.

AI powered detection and assessment of onychomycosis: A spotlight on yellow and deep learning

AbstractBackgroundDespite significant advances in computer‐aided diagnostics, onychomycosis, a widespread fungal nail infection, lacks an automated approach for objective analysis and classification.ObjectivesOur study aimed to develop and validate automated machine learning models to accurately detect and classify onychomycosis‐affected areas in toenails.MethodsThe images in this study were captured using the Scarletred® Vision mobile App and SkinPatch, a CE certified medical device system working seamlessly together to deliver auto‐color calibrated, high‐resolution clinical images. Considering a total of 1687 images from 440 subjects, the research explores various degrees of onychomycosis and evaluates the infection extent in the toenails detected. We developed an advanced machine learning algorithm for precise segmentation and classification of onychomycosis‐affected toenails, utilizing expert annotations and advanced post‐processing techniques. Additionally, an analysis of nail growth was performed, and a comparison graph with the percentage of infection was estimated.ResultsUsing advanced machine learning algorithms, we successfully detected toenails, enabling detailed analysis of intricate structures within the images. We achieved a final validation loss of 0.0236 and an F1 score of 0.8566 for accurate toenail detection, while the Random Forest algorithm demonstrated 81% accuracy in classifying and distinguishing between infected and healthy toenail areas. Our applied superpixel method furthermore improved the algorithm's precision in identifying the infected regions.ConclusionsOur AI‐powered image analysis method, initially focused on the big toe's toenail, shows great promise for broader validation on comprehensive datasets, enabling more detailed assessments of onychomycosis severity and disease dynamics. The potential impact of limited patient diversity, particularly with darker skin tones, needs further assessment. Proven to measure nail growth and assess treatment effectiveness over time, our developed AI is the first of its kind to demonstrate this capability, representing a significant advancement as a novel decision support tool for clinical research and routine medical practice.

Addressing Challenges to Enhance Clinical Research in Portugal: Insights from the OncoT3 Expert Group Delphi Study.

Introduction Over the past decades, clinical research has evolved significantly, driven by advances in regulatory frameworks, technological innovations, and methodological approaches. In Portugal, while there has been progress - such as increased regulatory alignment with European standards and the adoption of digital trial management tools - various challenges remain. These may include, among others, limited access to funding, slower patient recruitment rates, and regulatory hurdles that can delay trial approvals. Our goal was to identify key areas for improvement toward the optimization of clinical research practices in the country. Methods A modified three-round Delphi study was conducted online (2023-2024) to achieve a nationwide expert consensus. The scientific committee, composed of seven experts, developed 45 initial statements across five topics: dedication time to clinical research, organization of integrated research centers, conditions for implementing clinical trials, the role of institutional authorities, and patient recruitment and referral. A five-point Likert-type scale was used (1 - 'strongly disagree', 2 - 'disagree', 3 - 'neither agree nor disagree', 4 - 'agree', and 5 - 'strongly agree') to rate each statement. The consensus threshold was established as a percentage of agreement among participants (≥90% in the first round and ≥85% in the second round). The level of consensus achieved by the panel was discussed by the scientific committee during virtual meetings. Results Fifty-one experts completed the exercise (86.4% response rate). Consensus was reached on 32 of the 45 initial statements (71.1%) in the first round, with most of them (n = 20, or 62.5%) presenting high concordance rates (>95%). Four new statements were added for the second round, grounded on the feedback from the experts. By the end of the study, consensus was achieved on 45 out of the 49 final statements (91.8%), with the greatest agreement on the organization of integrated research centers and conditions for implementing clinical trials. Three statements regarding patient recruitment and referral, and one statement on the role of institutional authorities to promote clinical research, did not reach consensus, highlighting the need for further dialogue and innovative solutions in these fields. Conclusion The insights of this study can inform health organizations, regulatory agencies, and other stakeholders about the barriers and opportunities to improve clinical research in Portugal. By learning from global best practices and tailoring strategies to local contexts, the country can become a more prominent player in the international community.

2000~2023년 국내 음악치료 연구의 트렌드 분석: 키워드 의미 네트워크 접근

Objectives The purpose of this study is to select literature related to music therapy in South Korea published in KCI academic journals from 2000 to 2023, in order to examine trends in domestic music therapy research and to suggest future directions for music therapy research. Methods From August 2022 to January 2024, a total of 542 research articles were selected from major domestic academic journal sites. Among 705 types of refined 1,799 keywords identified, 100 keywords that appeared six or more times were extracted. Synonyms were represented with a consistent expression, and compound words were separated and standardized. The refined keywords were validated for appropriateness by three experts. The UCINET 6.0 program visualized the keyowrds with NetDraw. Results The overall keyword network, consisting of 100 nodes connected by 1,422 links, had a density of .144. The keywords ‘instrument playing,’ ‘sociality,’ ‘depression,’ and ‘anxiety’ showed high centrality in terms of degree, closeness, and betweenness, confirming them as the core keywords in domestic music therapy research. Conclusions By identifying the core keywords in domestic music therapy research, this study sheds light on past research trends and discusses the considerations for applying current research in clinical practice, as well as the direction and factors to consider for future research. This is the significance of this study.

Real-Time Data Collection Utilizing Mobile Technology in Clinical Research: A Secondary Analysis of a Prospective Cohort.

Clinical research faces the challenge of declining physician participation in the pursuit of advancing evidence-based medicine. This secondary analysis focuses on the interactive mobile health (mHealth) application's utility as a real-time data collection tool in clinical settings, specifically targeting cow's milk protein allergy (CMPA) management. The study assesses the mHealth application's potential to alleviate data collection inefficiencies and improve physician engagement in clinical research. The analysis utilized de-identified survey data from a prospective cohort of 61 physicians who employedan interactive mobile survey application over 12 weeks, documenting 808 patient visits. Of these physicians, 52 (85%) completed initial and follow-up surveys, with the predominant reason for exclusion being incomplete or non-submission of data. Of the 404 patient surveys collected, 75 (19%) were excluded primarily due to the absence of follow-up information. These results underscore the application's practicality in streamlining clinical data collection, evidenced by the high rate of survey completion and the efficiency of data management among participating physicians. The findings indicate that interactive mobile health applications aided in collecting and managing clinical data, with 85% of physicians completing surveys for initial and follow-up visits. This high completion rate suggests the potential for mobile applications to mitigate traditional barriers to physician participation, such as time constraints and complex data management. The study contributes empirical evidence to the potential of mobile technology in enhancing research efficiency and engagement among physicians in the context of CMPA management. While the results are insightful, further studies are encouraged to extend the utility of the interactive mobile survey application and similar technologies across diverse clinical research areas, reinforcing mobile technology's role in transforming clinical research practices.

Clinical indications associated with new opioid use for pain management in the United Kingdom: using national primary care data.

Prescription opioids for noncancer pain in the United Kingdom have increased over the past 2 decades, alongside associated harms. Policies addressing opioid prescribing must be tailored to individual patient needs with specific disease systems. The aim of this study was to evaluate clinical conditions associated with new opioid initiation in noncancer pain using nationally representative UK data. Primary care electronic health records from January 1, 2006, to September 31, 2021, were used from the Clinical Research Practice Datalink to identify incident opioid prescriptions. Patient histories were reviewed using code lists for opioid-related conditions with a 5-year look-back for chronic conditions and a 1-year look-back for surgical indications before opioid initiation. In total, 3,030,077 new opioid use episodes in 2,027,402 patients were identified, with 61% being women, 77% aged 45 years and older, and 48% from the highest deprivation quintile. Ten systems associated with opioid initiation were identified, which were not mutually exclusive, as patients could have opioids prescribed for multiple indications. The most common were musculoskeletal (80.8%), respiratory (57.6%), infections (30.4%), trauma/injury (20.4%), neurology (19.9%), and postsurgical indications (5.5%). Osteoarthritis (60.7%) and low back pain (41.0%) were the most frequent musculoskeletal conditions. Orthopedic surgeries accounted for 41.2% of all postsurgical indications. This is the first study in the United Kingdom evaluating large-scale national data to assess indications associated with opioid initiation. Nearly 3 quarters of new opioid prescriptions for noncancer pain were in patients with musculoskeletal conditions, often for conditions with limited evidence for opioid efficacy. These findings could inform targeted interventions and future policies to support nonpharmacological interventions in the most common conditions where opioid harms outweigh benefits.

Ensuring Quality in Clinical Research: The Impact of Quality Assurance and Quality Control in the Field of Good Clinical Practice

Good Clinical Practice (GCP) compliance delivers assurance that the study participants' safety is protected and that the obtained data are legitimate and credible. One of the tools to obtain quality in clinical research is to assure robust quality assurance and quality control as part of the quality management system. This is considered essential for sponsors to assure that the data from the clinical trial have integrity and reliability. One of the purposes of this article was to provide information to allow clinical research, quality assurance professionals, academics, and members of ethics committees to stay up to date with clinical research and good practice developments. This article investigates the enormous value of quality assurance and control in clinical trials, highlighting their pivotal role in ensuring the integrity, safety, and efficacy of research findings.

Breast-cancer specific comprehensive archive of Patient-Reported Outcome Measures (PROMs) for clinical research and clinical practice in oncology: Results from the PRO4All project

BackgroundInclusion of patient-reported outcomes (PROs) in oncology clinical trials is strongly recommended. However, selecting the most appropriate patient-reported outcome measures (PROMs) is not easy. This study aimed to develop a breast cancer (BC) specific comprehensive archive of PROMs. MethodsAs part of the PRO4All project, we identified available PROMs in oncology by searching facit.org, eortc.org, eprovide.mapi-trust.org, PubMed, ema.europa.eu (European Public Assessment Reports) and published reviews. For this analysis, only BC tools were extracted. We described information about PROM name, type of questionnaire, questionnaire variant(s), recall period, number of items, and presence of minimum clinically important difference (MCID) reference in literature. Then, we assigned each item to a specific domain according to a predefined taxonomy of 38 items for outcome classification. ResultsWe identified and analyzed 383 PROMs. Of these, 29 were BC specific, but 2 were excluded because the questionnaires description was not available. 6 (22.2 %) were variants of another questionnaire. All questionnaires were self-reported. In 6 cases (22.2 %) the recall period to consider was the “last week”. The mean number of items per questionnaire was 25.81 (range 6–71). 602 items were assigned to an outcome domain: emotional functioning/wellbeing in 26.6 % of cases, physical functioning in 14.1 %, delivery of care in 10.8 %, and general outcomes in 10.5 %. MCID reference was found only in 4 (14.8 %) cases. ConclusionsThe newly developed archive represents a useful tool to optimize the use of PROMs in the evaluation of treatments in BC patients, promoting a patient-centered approach both in clinical research and practice.

Importance of ferritin research in clinical practice

Serum ferritin (SF) is typically present in serum at concentrations directly related to iron (Fe) storage and is therefore traditionally used as an indicator of Fe levels in body tissues. Reducing its level is the “gold standard” for diagnosing widespread iron deficiency conditions. No less significant is hyperferritinemia — a nonspecific syndrome that occurs when Fe reserves are overloaded, a number of immunoinflammatory, infectious, oncological diseases, liver diseases, etc. In many pathological conditions, the level of SF determines the severity and prognosis of the disease. Ferritin concentrations greater than 1000 ng/mL, regardless of cause, have been shown to be associated with higher mortality. The reason for the increase in the level of SF in liver pathologies (cancer, hepatitis, cirrhosis) is associated with the process of its release from hepatocytes during their destruction. On the other hand, excessive synthesis and/or cellular secretion of ferritin occurs under the influence of various stimuli (cytokines, oxidative stress, hypoxia, oncogenes and growth factors). The interpretation of elevated ferritin values goes far beyond the role of an indicator of replenishment of Fe stores in tissues. Only 10% of cases of hyperferritinemia are associated with iron overload; in most patients, it is defined as the result of the acute phase and a reactive increase in ferritin levels against the background of any disease. The variety of symptoms of iron deficiency syndromes and hyperferritinemia is due to the involvement of many organs and systems, which requires a thorough examination (study of complaints, anamnesis, family and concomitant diseases, as well as the necessary laboratory and instrumental studies) to search for possible causes. Systemic Fe homeostasis must be closely monitored on a regular basis. It is required to comply with the conditions for blood sampling for SF. Reference values for SF concentrations vary depending on the analytical methods used and the population studied. Age and gender play an important role. Given the range of reference values, it is important for a particular patient to focus on the initial level of his ferritin, determined against the background of health and well-being during clinical observation.

"Academic Influence and Industry Funding in Nerve Allograft Research: A Co-Authorship Network Analysis".

Clinical use of acellular nerve allografts is rapidly increasing despite limited high-quality, comparative evidence of superiority. Simultaneously, non-research payments to clinicians by the nerve allograft industry exceeds $14,000,000 over the last decade. In this study, the authors hypothesized that nerve allograft-related academic influence would correlate with industry funding. PubMed studies on nerve allografts in plastic and reconstructive surgery journals were reviewed. Using author lists from extracted studies, a co-authorship network was generated and degree centralities - quantitative measurements of influence within a network - were calculated. Open Payments data from the nerve allograft industry was summated for each author. Finally, Pearson correlation and linear regression were used to analyze the relationship between centrality and payments received. 185 studies were included, with 581 unique authors (nodes) and 2,406 co-authorships (ties) between them. Among authors with exceptional network influence (centrality >10, 75th percentile; n=113), 56 were clinicians with valid NPIs and therefore eligible for inclusion in the Open Payments database. 44 (79%) of these authors received at least one payment from the industry. Pearson correlation revealed a moderate (0.4<r<0.6) positive correlation between centrality and payments received (r=0.51, p<0.001). Linear regression demonstrated an estimated 16% increase in total pay per additional unit of centrality (p<0.001; 95% CI [8%, 25%]). There is a significant connection between academic influence and financial support from the nerve allograft industry. Such results warrant discussion concerning conflicts of interest in clinical research and best practices for mitigating potential bias related to commercially backed treatments.

Lack of Integration of Research in Clinical Practice: A Qualitative Study of Clinical Academics’ Challenges in the Workplace Environment of Danish Hospitals

Lack of Integration of Research in Clinical Practice: A Qualitative Study of Clinical Academics’ Challenges in the Workplace Environment of Danish Hospitals

Transfer of results into clinical practice and citizen participation in health care research

Transfer of results into clinical practice and citizen participation in health care research

Factors Affecting Health Research Utilization Among Health Professionals in Nigeria

The utilization of health research in clinical practice is hindered by individual, organizational, and systemic barriers, including insufficient research literacy and unsupportive organizational cultures. Enhancing research literacy, fostering supportive environments, and implementing evidence-based policies are crucial for bridging the gap between research and practice, ultimately improving patient outcomes. This study investigates the factors affecting health research utilization among health professionals in Nigeria, an essential aspect for advancing healthcare systems and patient outcomes. Utilizing a cross-sectional descriptive design, data were collected via an online survey distributed to public health professionals and policymakers. The survey explored demographics, research utilization, dissemination effectiveness, barriers, and recommendations for improvement. Key findings indicate significant demographic disparities, with a higher proportion of younger and non-public health degree holders reporting unused research findings. The study identified major barriers, including inadequate communication, poor dissemination practices, and lack of access to research findings. Despite 87.6% of respondents conducting potentially impactful research, only 13.6% reported actual utilization of their findings. The recommendations for improvement emphasized the role of knowledge brokers, fostering research-attuned and decision-relevant cultures, enhancing communication and interaction between researchers and users, and building capacity among all stakeholders. Additionally, establishing effective dissemination systems, securing funding, and promoting international collaboration were highlighted as critical strategies. The study underscores the necessity of addressing structural, cultural, and communicative barriers to improve the practical application of health research in Nigeria, aligning with global trends and literature advocating for a multifaceted approach to enhance health outcomes.

Enhancing the physician-scientist workforce: evaluating a mentored research program for medical students' research competencies and intentions.

The growing recognition of the need to incorporate scientific discoveries into healthcare decisions underscores an urgency for a robust physician-scientist workforce to advance translational research. Despite the correlation between medical students' research engagement and their academic productivity and success, significant gaps remain in the scientific workforce exacerbated by the "leaky pipeline" phenomenon from medical school to academic medicine, where potential physician-scientists veer away from research careers.The purpose of this study was to assess the effectiveness of a structured mentored research program for enhancing medical students' research competencies and sustaining their interest in research careers, thereby potentially enhancing the physician-scientist workforce. The Medical Student Research Program (MSRP) implemented at the University of California, Irvine (UCI) was designed to provide comprehensive research training and support to medical students through a series of structured lectures, mentorship by dedicated faculty, and administrative support for research activities. Students were surveyed upon enrollment and one year later to assess the change in research competencies from baseline to follow-up (paired samples t-test), students' intent to use research in clinical practice (paired samples t-test), and their intent to conduct research in the future (McNemar's test and McNemar Bowker test). Preliminary evaluations indicated that the MSRP enhanced students' research competencies and has the potential to enhance medical students' research skills. However, similar to national trends, there was a decrease in students' intentions to engage with research in their future clinical career. Our preliminary findings demonstrate MSRP students' enhanced research competencies during the first year of the program. However, the decline in students' intentions to engage in future research highlights the need for continued innovation in research training programs to sustain future intent to conduct research, in turn helping to address the "leaky pipeline" in the physician-scientist workforce. Future studies should focus on mid and long-term outcomes to fully assess research program impact on the physician-scientist pipeline and on integrating such programs more broadly into medical education.