Clinical Pulmonary Medicine Research Articles

Editorial introductions.

Editorial introductions.

Editorial introductions

Editorial introductions

“BLACK-MARKET” COSMETIC INJECTIONS IN A TRANSGENDER FEMALE RESULTING IN SILICONE EMBOLI SYNDROME AND INTERSTITIAL LUNG DISEASE

SESSION TITLE: Fellows Diffuse Lung Disease SESSION TYPE: Fellow Case Reports PRESENTED ON: October 18-21, 2020 INTRODUCTION: A thrombotic pulmonary embolism is a commonly encountered diagnosis that is often on the forefront of our minds when evaluating a patient with dyspnea. In direct contrast, nonthrombotic emboli are less frequently encountered, span a diverse set of etiologies, and involve varied pathogenesis, other than traditional mechanical obstruction as with ordinary pulmonary emboli. Septic, fat, talc, venous air, amniotic fluid, tumor, iodinated oil, mercury, hydatid, cotton, and catheter have all been described as different emboli involving the pulmonary circulation. We report a case of cosmetic injections with silicone and mineral oil in a transgender female resulting in silicone emboli syndrome and subsequent interstitial lung disease (ILD) and worsening hypoxia. CASE PRESENTATION: A 40 year old transgender female presented to our hospital with worsening dyspnea, cough, and hypoxemia over the course of a year. Her medical history was notable for multiple silicone and mineral oil cosmetic injections to her breasts, thighs, and buttocks, which the patient described as “black-market procedures.” The patient was hypoxic on presentation, requiring 3L of oxygen via nasal cannula, but otherwise was hemodynamically stable and afebrile. Her physical examination and laboratory studies were unremarkable. A chest radiograph revealed peripheral bibasilar reticular opacities. A CT chest showed diffuse reticulation, interlobular septal thickening, scattered nodules, and ground glass opacities. A bronchoscopy with bronchioalveolar lavage and transbronchial biopsies was performed. Pathology revealed spheroid silicone particles in the lung interstitium and capillaries, with histiocytic reaction and fibrosis. The diagnosis of interstitial lung disease due to silicone embolism syndrome was granted. The patient was trialed on steroids, without improvement in symptoms. She was discharged with supplemental oxygen with referral for lung transplant evaluation. DISCUSSION: Following subcutaneous injection, often from cosmetic procedures by nonmedical practitioners, liquid silicone enters the pulmonary circulation. Once in the pulmonary capillaries, interstitial inflammation, increased vascular permeability, alveolar edema and hemorrhage can ensue. Clinical features include hypoxia, dyspnea, fever, alveolar hemorrhage, and cough, with both acute and chronic presentations. CT findings of reticulonodular opacities and interlobular septal thickening are suggestive. Histopathology reveals globular deposits, alveolar inflammatory infiltrates, fibrosis, and hemorrhage. Treatment with steroids has been reported with favorable outcomes, however, severe cases can lead to ARDS and death. CONCLUSIONS: This case highlights the importance of a thorough exposure history when evaluating patients with ILD. Additionally, it is imperative to promote the awareness of this potentially lethal complication of cosmetic silicone injections. Reference #1: Zamora, A.C., Collard, H.R., Barrera, L. et al. Silicone Injection Causing Acute Pneumonitis: A Case Series. Lung 187, 241–244 (2009) Reference #2: Dawn, Samuel K. MD*; Elicker, Brett M. MD*; Leung, Jessica W. T. MD†; Reddy, Gautham P. MD, MPH*; Gotway, Michael B. MD‡ The Silicone Syndrome, Clinical Pulmonary Medicine: March 2006 - Volume 13 - Issue 2 - p 146-147. Reference #3: Sridhara S, Baksh M, Batool K, Chowdhury J, Reddy V, Norwood S, Sivaswami S. A rare case of delayed chronic pneumonitis following non-medical grade silicone injections in a transgender woman. J Unexplored Med Data 2018;3:1. DISCLOSURES: No relevant relationships by Astrid Carrion Rodriguez, source=Web Response No relevant relationships by Andrew Daya, source=Web Response No relevant relationships by Christine Girard, source=Web Response No relevant relationships by Nydia Martinez, source=Web Response No relevant relationships by Rajaganesh Rajagopalan, source=Web Response

Editorial introductions

Current Opinion in Infectious Diseases was launched in 1988. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of infectious diseases is divided into 11 sections that are reviewed once a year. Each section is assigned to a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editors for this issue. SECTION EDITORS Matteo BassettiMatteo BassettiMatteo Bassetti is Head of the Infectious Diseases Division of the Santa Maria Misericordia University Hospital in Udine and Associate Professor of Infectious Diseases at the University of Udine, Italy. Dr Bassetti studied at the University of Genoa School of Medicine, Italy and continued his medical education at the Yale University School of Medicine, New Haven, USA with an Infectious Diseases fellowship. Dr Bassetti is chair of the Critically Ill Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the secretary of the Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC). Dr Bassetti is also co-chair of the Intra-abdominal Infections Study Group and secretary of the Bone, Skin and Soft Tissue Infections of the International Society of Chemotherapy (ISC). He is the vice-president of Italian Society of Anti-infective Therapy (SITA). He is member-elected (2018–2022) of International Council of the Immunocompromised Host Society (ICHS). He serves on the editorial board of several journals including Intensive Care Medicine (Associate-Section Editor), Nature Scientific Reports, Italian Journal of Medicine (Section Editor), Drugs in Context (Associate editor), Journal of Infection and Public Health, Journal of Global Antimicrobial Resistance, Reviews in Medical Microbiology, GMS Infectious Diseases, Journal of Chemotherapy, Infectious Disease, Clinical Microbiology and Antimicrobial Chemotherapy and is a reviewer for several international journals. Author or co-author of more than 350 papers (H index 51; 10500 citations) published in international peer-review journals on antibiotic therapy, fungal infections, antimicrobial resistances, infections in immunocompromised patients and critically ill patients. Michael S. NiedermanMichael S. NiedermanProfessor Michael S. Niederman is Clinical Director and Associate Chief in the division of Pulmonary and Critical Care Medicine at Weill Cornell Medical Center, New York, and Professor of Clinical Medicine at Weill Cornell Medical College, New York. Prior to this, he was Professor in the Department of Medicine at State University of New York at Stony Brook, and Chairman of the Department of Medicine at Winthrop University Hospital in Mineola, New York for sixteen years. He obtained his medical degree from the Boston University School of Medicine, Massachusetts, and then completed his training in internal medicine at the Northwestern University School of Medicine, Illinois, before undertaking a Pulmonary and Critical Care fellowship at Yale University School of Medicine, Connecticut. His interests lie in respiratory tract infections, and include mechanisms of airway colonization, the management of community - and hospital-acquired pneumonia, the role of guidelines for pneumonia, and the impact of antibiotic resistance on the management and outcomes of respiratory tract infections. He has published over 400 peer-reviewed or review articles, and has lectured widely both nationally and internationally. Prof. Niederman served as co-chairman of the committees that created the American Thoracic Society 1993 and 2001 guidelines for the treatment of community-acquired pneumonia, as well as the 1996 and 2005 committees that wrote guidelines for the treatment of nosocomial pneumonia. In addition, he was a member of the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) committee that published guidelines for community-acquired pneumonia in 2007 and co-lead author of the 2017 European Respiratory Society/European Society of Intensive Care Medicine (ERS/ESICM) guidelines for nosocomial pneumonia. He served for 6 years as a member of the Board of Regents of the American College of Chest Physicians and in 2013 was elected as a Master of the American College of Physicians. He is also Editor-in-Chief of Clinical Pulmonary Medicine, and serves on the editorial boards of Critical Care Medicine, Intensive Care Medicine, Critical Care, and Chest. He has previously served on the editorial board of The American Journal of Respiratory and Critical Care Medicine.

Editorial introductions

Editorial introductions

Editorial introductions

Current Opinion in Infectious Diseases was launched in 1988. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of infectious diseases is divided into 11 sections that are reviewed once a year. Each section is assigned to a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editors for this issue. SECTION EDITORS Matteo BassettiMatteo BassettiProfessor Matteo Bassetti is Head of the Infectious Diseases Division of the Santa Maria Misericordia University Hospital, Udine, Italy and Associate-Professor of Infectious Diseases at the University of Udine. He studied at the University of Genoa School of Medicine, Italy and continued his medical education at the Yale University School of Medicine, Connecticut, USA with an infectious diseases fellowship. He also completed a PhD in solid organ transplantation and infectious diseases at the University of Genoa School of Medicine. Professor Bassetti is the chair of the Critically Ill Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and a member of the executive committee of the Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC). Professor Bassetti is also co-chair of the Intra-Abdominal Infections Study Group and secretary of the Bone, Skin and Soft Tissue Infections of the International Society of Chemotherapy (ISC). Professor Bassetti is the vice-president of Italian Society of Anti-Infective Therapy (SITA). He serves on the editorial board of several journals including Intensive Care Medicine (Associate-Section Editor), Journal of Global Antimicrobial Resistance, Journal of Infection and Public Health, Italian Journal of Medicine (Section Editor), Reviews in Medical Microbiology, Journal of Chemotherapy, and Scientific Reports and is reviewer for various international journals. Prof. Bassetti has authored or co-authored over 250 papers published in international peer-reviewed journals with more than 7000 citations (H-index 42). His main interests are bacterial resistance, fungal infections and infections in critically ill patients. Michael S. NiedermanMichael S. NiedermanProfessor Michael S. Niederman is Clinical Director and Associate Chief in the division of Pulmonary and Critical Care Medicine at Weill Cornell Medical Center, New York, and Professor of Clinical Medicine at Weill Cornell Medical College, New York. Prior to this, he was Professor in the Department of Medicine at State University of New York at Stony Brook, and Chairman of the Department of Medicine at Winthrop University Hospital in Mineola, New York for sixteen years. He obtained his medical degree from the Boston University School of Medicine, Massachusetts, and then completed his training in internal medicine at the Northwestern University School of Medicine, Illinois, before undertaking a pulmonary and critical care fellowship at Yale University School of Medicine, Connecticut. His interests lie in respiratory tract infections, and include mechanisms of airway colonization, the management of community- and hospital-acquired pneumonia, the role of guidelines for pneumonia, and the impact of antibiotic resistance on the management and outcomes of respiratory tract infections. He has published over 400 peer-reviewed or review articles, and has lectured widely both nationally and internationally. Prof. Niederman served as co-chairman of the committees that created the American Thoracic Society 1993 and 2001 guidelines for the treatment of community-acquired pneumonia, as well as the 1996 and 2005 committees that wrote guidelines for the treatment of nosocomial pneumonia. In addition, he was a member of the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) committee that published guidelines for community-acquired pneumonia in 2007 and co-lead author of the 2017 European Respiratory Society/European Society of Intensive Care Medicine (ERS/ESICM) guidelines for nosocomial pneumonia. He served for 6 years as a member of the Board of Regents of the American College of Chest Physicians and in 2013 was elected as a Master of the American College of Physicians. He is also Editor-in-Chief of Clinical Pulmonary Medicine, and serves on the editorial boards of Critical Care Medicine, Intensive Care Medicine, Critical Care, and Chest. He has previously served on the editorial board of The American Journal of Respiratory and Critical Care Medicine.

Editorial introductions

Editorial introductions

Editorial introductions

Current Opinion in Infectious Diseases was launched in 1988. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of infectious diseases is divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editors for this issue. SECTION EDITORS Matteo BassettiMatteo BassettiMatteo Bassetti is Head of the Infectious Diseases Division of the Santa Maria Misericordia University Hospital, Udine, Italy and Associate-Professor of Infectious Diseases of the University of Udine. He studied at the University of Genoa School of Medicine and continued his medical education at the Yale University School of Medicine, New Haven, USA with an Infectious Diseases fellowship. He also completed a PhD in Solid Organ Transplantation and Infectious Diseases at the University of Genoa School of Medicine. Professor Bassetti is the chair of the Critically Ill Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and member of executive committee of the Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC). Professor Bassetti is also co-chair of the Intra-Abdominal Infections Study Group and secretary of the Bone, Skin and Soft Tissue Infections of the International Society of Chemotherapy (ISC). Prof Bassetti is the vice-president of Italian Society of Anti-infective Therapy (SITA). He serves on the editorial board of several journals including Intensive Care Medicine (Associate-Section Editor), Journal of Global Antimicrobial Resistance, Journal of Infection and Public Health, Italian Journal of Medicine (Section Editor), Reviews in Medical Microbiology, Journal of Chemotherapy, Infectious Disease, Scientific Reports and is reviewer for various international journals. Prof Bassetti has authored or co-authored over 250 papers published in international peer-reviewed journals with more than 7000 citations (Hindex 42). The main interest are bacterial resistance, fungal infections and infections in critically ill patients. Michael S. NiedermanMichael S. NiedermanMichael S. Niederman is Clinical Director, and Associate Chief, in the division of Pulmonary and Critical Care Medicine, at Weill Cornell Medical Center, and Professor of Clinical Medicine at Weill Cornell Medical College. Prior to this, he was Professor in the Department of Medicine at the State University of New York at Stony Brook, and Chairman of the Department of Medicine at Winthrop-University Hospital in Mineola, New York for 16 years. He obtained his medical degree from Boston University School of Medicine, and then completed his training in internal medicine at Northwestern University School of Medicine, before undertaking a pulmonary and critical care fellowship at Yale University School of Medicine. His interests lie in respiratory tract infections, and include mechanisms of airway colonization, the management of community- and hospital-acquired pneumonia, the role of guidelines for pneumonia, and the impact of antibiotic resistance on the management and outcomes of respiratory tract infections. He has published over 400 peer reviewed or review articles, and has lectured widely, both nationally and internationally. Dr Niederman served as co-chairman of the committees that created the American Thoracic Society 1993 and 2001 guidelines for the treatment of community-acquired pneumonia and the 1996 and 2005 committees that wrote guidelines for the treatment of nosocomial pneumonia. He was a member of the ATS/IDSA committee that published guidelines for community-acquired pneumonia in 2007. He served for 6 years as a member of the Board of Regents of the American College of Chest Physicians and in 2013 was elected as a Master of the American College of Physicians. He is also Editor-in-Chief of Clinical Pulmonary Medicine, and serves on the editorial boards of Critical Care Medicine, Intensive Care Medicine, Critical Care and Chest. He has previously served on the editorial board of The American Journal of Respiratory and Critical Care Medicine.

Editorial introductions

Current Opinion in Infectious Diseases was launched in 1988. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of infectious diseases is divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editors for this issue. SECTION EDITORS Matteo BassettiMatteo BassettiMatteo Bassetti is Head of the Infectious Diseases Division of the Santa Maria Misericordia University Hospital, Udine, Italy. He is also Professor of Infectious Diseases at School of Medicine of the University of Udine. Dr Bassetti studied at the University of Genoa School of Medicine, Italy, and continued his medical education at the Yale University School of Medicine, New Haven, USA, with an Infectious Diseases fellowship. He also completed a PhD in Solid Organ Transplantation and Infectious Diseases at the University of Genoa School of Medicine. Dr Bassetti is the Secretary of the Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC) and Vice-Chair of the Critically Ill Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Dr Bassetti is also Co-Chair of the Intra-abdominal Infections Study Group and Secretary of the Bone, Skin and Soft Tissue Infections of the International Society of Chemotherapy (ISC). Dr Bassetti is a member of many professional societies, including the Infectious Diseases Society of America (IDSA) and ESCMID. He is the Vice-President of Italian Society of Anti-infective Therapy (SITA). He serves on the editorial board of several journals including Intensive Care Medicine (Associate-Section Editor), Italian Journal of Medicine (Section Editor), Journal of Global Antimicrobial Resistance, Reviews in Medical Microbiology, Journal of Chemotherapy, Infectious Disease, Scientific Reports and is a reviewer for various international journals. He has been principal investigator for many trials on antibiotics and antifungal agents. Dr Bassetti has authored or co-authored over 250 papers published in international peer-reviewed journals with more than 4500 citations (Hindex 35). Michael S. NiedermanMichael S. NiedermanMichael S. Niederman is Professor of Clinical Medicine at Weill Cornell Medical College, Cornell University, USA. He obtained his medical degree from Boston University School of Medicine, USA, and then completed his training in internal medicine at Northwestern University School of Medicine, USA, before undertaking a pulmonary and critical care fellowship at Yale University School of Medicine, USA. His interests lie in respiratory tract infections, and include mechanisms of airway colonization, the management of community- and hospital-acquired pneumonia, the role of guidelines for pneumonia, and the impact of antibiotic resistance on the management and outcomes of respiratory tract infections. He has published over 350 peer reviewed or review articles, and has lectured widely, both nationally and internationally. Dr Niederman served as co-chairman of the committees that created the American Thoracic Society 1993 and 2001 guidelines for the treatment of community-acquired pneumonia and the 1996 and 2005 committees that wrote guidelines for the treatment of nosocomial pneumonia. He was a member of the American Thoracic Society/Infectious Diseases Society of America committee that published guidelines for community-acquired pneumonia in 2007. He is also Editor-in-Chief of Clinical Pulmonary Medicine, and has served on the editorial boards of The American Journal of Respiratory and Critical Care Medicine, Critical Care Medicine, Critical Care, Intensive Care Medicine and Chest.

Health-related quality of life in a nationwide cohort of patients with COPD related to other characteristics

BackgroundIn chronic obstructive pulmonary disease (COPD), various factors, such as dyspnoea, obstruction, exacerbations, smoking, exercise capacity, and body mass index, have been found to influence mortality and health-related quality of life (HRQOL). In order to identify subgroups of patients needing special attention, the aim of the present study was to explore the relationships between disease progression factors and HRQOL across COPD stages.MethodsBaseline registrations from the Swedish COPD register of demographic, clinical, and patient-reported variables of 7,810 patients are presented. Dyspnoea was measured by the modified Medical Research Council (mMRC) dyspnoea scale and HRQOL by the Clinical COPD Questionnaire (CCQ).ResultsThis study shows as expected that patients with spirometrically more severe COPD had a significantly higher number of exacerbations and hospitalisations, significantly increasing dyspnoea, significantly decreasing body mass index and exercise capacity, and significantly worsening HRQOL. When adjusting for spirometric stage of COPD, deteriorated HRQOL was predicted by increasing dyspnoea, depression/anxiety, increasing number of exacerbations, and decreased exercise capacity. Further, these data show that an mMRC value of 2 corresponds to a CCQ value of 1.9.ConclusionThe COPD patients suffered from a significant symptom burden, influencing HRQOL. A surprisingly great proportion of patients in spirometric stages II–IV showed marked changes of CCQ, indicating a need for an improved collaboration between clinical pulmonary medicine and palliative care.

Editorial introductions

Editorial introductions

Editorial introductions

Current Opinion in Infectious Diseases was launched in 1988. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of infectious diseases is divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editors for this issue. SECTION EDITORS Matthew S. DrydenMatthew S. DrydenMatthew S. Dryden is a Clinical Director of Infection at the Hampshire Hospitals Trust in Winchester, UK, and the Rare and Imported Pathogens Department, PHE and an honorary senior lecturer at Southampton University Medical School, UK. He is a visiting Professor at St George's University School of Medicine in Grenada, West Indies, and consultant to the Falkland Islands and St Helena Governments Health Services. He is General Secretary of the British Society for Antimicrobial Chemotherapy, a member of the executive committee of the International Society of Chemotherapy and a Fellow of the Royal Geographical Society and the Royal College of Pathologists. Dr Dryden has an interest in travel medicine and is a partner in Winchester Travel Health. His department has a link with Yei Hospital in Southern Sudan. His research interests have been in staphylococcal infection, skin and soft tissue infection, the development of new antibiotics, antibiotic stewardship, the management of MRSA infections, and Lyme disease in the UK. Michael S. NiedermanMichael S. NiedermanMichael S. Niederman is Professor and Vice-Chairman of the Department of Medicine at the State University of New York at Stony Brook, USA, and Chairman of the Department of Medicine at Winthrop-University Hospital in Mineola, New York, USA. He obtained his medical degree from Boston University School of Medicine, USA, and then completed his training in internal medicine at Northwestern University School of Medicine, USA, before undertaking a pulmonary and critical care fellowship at Yale University School of Medicine, USA. His interests lie in respiratory tract infections, and include mechanisms of airway colonization, the management of community- and hospital-acquired pneumonia, the role of guidelines for pneumonia, and the impact of antibiotic resistance on the management and outcomes of respiratory tract infections. He has published over 350 peer reviewed or review articles, and has lectured widely, both nationally and internationally. Dr Niederman served as co-Chairman of the committees that created the American Thoracic Society 1993 and 2001 guidelines for the treatment of community-acquired pneumonia and the 1996 and 2005 committees that wrote guidelines for the treatment of nosocomial pneumonia. He was a member of the ATS/IDSA committee that published guidelines for community-acquried pneumonia in 2007. He is also Editor-in-Chief of Clinical Pulmonary Medicine, and has served on the editorial boards of The American Journal of Respiratory and Critical Care Medicine, Critical Care Medicine, Critical Care, Intensive Care Medicine and Chest.

Editorial introductions

Current Opinion in Infectious Diseases was launched in 1988. It is part of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The field of infectious diseases is divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Section Editors for this issue. SECTION EDITORS Roderick James HayRoderick James HayProfessor Hay was born in Cobham, Surrey, he grew up in Devon and now lives in Shipton under Wychwood, Oxfordshire. He was educated at Oxford University, UK and Guys Hospital Medical School, London, UK and has been a Lecturer/Senior Registrar at the London School of Hygiene and Tropical Medicine, UK and at the St. Johns Hospital for Diseases of the Skin, London, UK. He has also been a Research Fellow at the Centers for Disease Control, Atlanta, USA. Professor Hay is currently Chairman of the International Foundation of Dermatology, London, Honorary Professor at the London School of Hygiene and Tropical Medicine and Consultant Dermatologist in Infectious Skin Disease at Kings College Hospital, London, UK. He is a former Head of the School of Medicine and Dentistry and Dean of the Faculty of Medicine and Health Sciences at Queens University, Belfast, Ireland and emeritus Professor of Dermatology. Professor Hay was President of the British Association of Dermatologists 2001–2002, the British Society for Medical Mycology 1997–2002, and the European Confederation of Medical Mycology 1998–2002. He serves on a number of boards including: the Eastern Health and Social Services Board and the International Committee of Dermatology; Professor Hay has authored over 500 scientific papers, books and reports on medical mycology and tropical dermatology, focusing on antifungal chemotherapy, cellular immunology and epidemiology. His present areas of research include studies of the virulence factors of pathogenic fungi and molecular diagnosis as well as health systems research in tropical skin disease. Michael S. NiedermanMichael S. NiedermanMichael Niederman is Professor and Vice-Chairman of the Department of Medicine at the State University of New York at Stony Brook, USA, and Chairman of the Department of Medicine at Winthrop-University Hospital in Mineola, New York, USA. He obtained his medical degree from Boston University School of Medicine, USA, and then completed his training in internal medicine at Northwestern University School of Medicine, USA, before undertaking a pulmonary and critical care fellowship at Yale University School of Medicine, USA. His interests lie in respiratory tract infections, and include mechanisms of airway colonization, the management of community- and hospital-acquired pneumonia, the role of guidelines for pneumonia, and the impact of antibiotic resistance on the management and outcomes of respiratory tract infections. He has published over 350 peer reviewed or review articles, and has lectured widely, both nationally and internationally. Dr Niederman served as co-chairman of the committees that created the American Thoracic Society 1993 and 2001 guidelines for the treatment of community-acquired pneumonia and the 1996 and 2005 committees that wrote guidelines for the treatment of nosocomial pneumonia. He was a member of the ATS/IDSA committee that published guidelines for community-acquried pneumonia in 2007. He is also Editor-in-Chief of Clinical Pulmonary Medicine, and has served on the editorial boards of The American Journal of Respiratory and Critical Care Medicine, Critical Care Medicine, and Chest.

Building-Related Illness

Abstract:Building-related illnesses represent a spectrum of disease. Important to their genesis are the unique features of the indoor air environment involving exposures to air pollution, mold spores, and various allergens. Specific building-related illnesses are primarily infectious, but also inclu

Interpreting Chest X-rays, 1st ed.

Clinical Pulmonary Medicine: November 2010 - Volume 17 - Issue 6 - p 311 doi: 10.1097/CPM.0b013e3181f9d7e4

Teaching pulmonary gas exchange physiology using computer modeling

Students often have difficulty understanding the relationship of O(2) consumption, CO(2) production, cardiac output, and distribution of ventilation-perfusion ratios in the lung to the final arterial blood gas composition. To overcome this difficulty, I have developed an interactive computer simulation of pulmonary gas exchange that is web based and allows the student to vary multiple factors simultaneously and observe the final effect on the arterial blood gas composition (available at www.siumed.edu/medicine/pulm/vqmodeling.htm). In this article, the underlying mathematics of the computer model is presented, as is the teaching strategy. The simulation is applied to a typical clinical case drawn from the intensive care unit to demonstrate the interdependence of the above factors as well as the less-appreciated importance of the Bohr and Haldane effects in clinical pulmonary medicine. The use of a computer to vary the many interacting factors involved in the arterial blood gas composition appeals to today's students and demonstrates the importance of basic physiology to the actual practice of medicine.

Proteomics in Pulmonary Medicine

Proteomics is the study of the entire protein complement of the genome (the proteome) in a biological system. Proteomic studies require a multidisciplinary approach and have only been practical with the convergence of technical and methodologic improvements including the following: advances in mass spectrometry and genomic sequencing that now permit the identification and relative quantization of small amounts (femtomole) of nearly any single protein; new methods in gel electrophoresis that allow the detection of subtle changes in protein expression, including posttranslational modifications; automation and miniaturization that permit high-throughput analysis of clinical samples; and new bioinformatics and computational methods that facilitate analysis and interpretation of the abundant data that are generated by proteomics experiments. This convergence makes proteomics studies practical for pulmonary researchers using BAL fluid, lung tissue, blood, and exhaled breath condensates, and will facilitate the research of complex, multifactorial lung diseases such as acute lung injury and COPD. This review describes how proteomics experiments are conducted and interpreted, their limitations, and how proteomics has been used in clinical pulmonary medicine.

Pulmonary Trends

Clinical Pulmonary Medicine: July 2003 - Volume 10 - Issue 4 - p 241-245 doi: 10.1097/01.cpm.0000080907.11193.fc

Editorial Comment about the AARC and Its Concerns about a Recently Published Article in Clinical Pulmonary Medicine

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious Issues CollectionsFor Authors Information for AuthorsLanguage Editing Services Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search

Clinical Pulmonary Medicine

<i>Clinical Pulmonary Medicine</i>, a journal for both pulmonologists in clinical practice and critical care specialists, was created to provide concise and easy-to-read review articles encompassing recent advances in pulmonary medicine. The bimonthly issues include one or occasionally two review articles in each of seven subspecialty areas: obstructive airway disease; respiratory infections; interstitial, inflammatory, and occupational diseases; clinical practice management; critical care; and two more general departments, "Colleagues in Respiratory Medicine" and "Topics in Pulmonary Medicine." Each issue also includes summaries and commentary on three or four recent articles from other clinical journals. This format, if it can be maintained, promises to provide a comprehensive but focused educational tool for keeping practitioners current on major developments affecting pulmonary practice. The editorial board, led by editor-in-chief Michael S. Niederman, includes an elite group of US clinical practitioners, representing a cross-section of major academic medical centers. The review articles themselves are solicited by