Clinical Prostate Carcinoma Research Articles

Latent carcinoma of prostate at autopsy in seven areas. The International Agency for Research on Cancer, Lyons, France.

A world-wide comparative study of the frequency and characteristics of latent carcinoma of the prostate was undertaken in seven areas, using standardized methods and "blind" microscopic evaluation in order to reduce selection and observer bias. The morphological features of 350 latent carcinomas found in 1,327 prostates were examined. Two Chinese populations, from Hong Kong and Singapore, showed a low frequency of latent carcinoma in comparison with western Europeans in Sweden and the Federal Republic of Germany and negroes from Jamaica; an intermediate position was found for Israelis and black Ugandans. The frequency of small latent carcinomas was about 12% in all the areas investigated and did not vary with age. Rates for larger latent carcinomas increased sharply with age ans showed an area-to-area variation resembling that of clinical carcinoma of prostate. The small carcinomas were almost exclusively situated in the outer half of the prostate and latent carcinomas of all sizes were evenly distributed between the anterior and posterior halves of the prostate and the right and left sides of the outer prostatic shell. Certain disagreements in diagnosis were noted when the sections from each area were evaluated independently by a different pathologist. Most of these disagreements were resolved by re-reading the sections; their occurrence had no significant effect on the geographical comparisons.

前立腺肥大症及び前立腺癌に於ける膠原量について

The collagen content in the prostatic tissues surgically removed from 54 patients with prostatic hypertrophy and prostatic carcinoma was measured by the Ishida's method, the modification of the Neuman and Logan's method. The collagen content was also measured in 7 normal cases for control.The results obtained were compared with the histological picture and summerized as follows:1) The average value of the collagen content in normal prostatic tissue was 6.3 per cent.2) The average value of the collagen content in prostatic hypertrophy was 9.8 per cent, higher than normal value.The average value of the collagen content in the fibroglandular type and the mixed type which contains abundant stroma was 10.4 per cent and 10.9 per cent respectively, both somewhat higher than in the glandular type, 8.6 per cent.3) The average value of the collagen content in prostatic tissue which showed histologically microfollicular hyperplasia was 9.8 per cent, same value as in general cases of hypertrophy.4) The average value of the collagen content in occult carcinoma was 11.9 per cent, practically as high as in prostatic carcinoma.5) The average value of the collagen content in prostatic carcinoma was as high as 12.0 per cent, about twice as normal value. The average value of collagen content in adenocarcinoma was 11.3 per cent, while that of scirrhus was 13.3 per cent.6) From the view point of collagen content, the prostatic carcinoma is different from the prostatic hypertrophy and the occult carcinoma may be considered to be identical with the clinical prostatic carcinoma, while the microfollicular hyperplasia may be one type of the prostatic hypertrophy.