This article summarizes the NCCN clinical practice guidelines for screening for colorectal cancer. This guideline provides recommendations for appropriate screening and management of abnormal findings in groups at both average and high risk. In its deliberations, the Colorectal Cancer Screening Panel identified populations at high risk to include both patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease) and individuals at risk because of a genetic predisposition. For the most recent version of the guidelines, please visit NCCN.org