Clinical Outcomes In Adolescents Research Articles

5. Clinical Outcomes in Adolescents Hospitalized With Anorexia Nervosa on a Higher Versus Lower Calorie Diet

We previously showed poor weight gain in hospitalized adolescents with Anorexia Nervosa (AN) on a conservative feeding protocol consistent with the current recommendations. At least one recent study has demonstrated the safety and efficacy of more aggressive refeeding (without tube feeding), and many clinical programs are now implementing these higher calorie diets. However, there are currently no studies comparing the two approaches. The purpose of this study was to examine clinical outcomes in hospitalized adolescents with AN on higher calorie diets as compared to lower calorie diets.

Clinical Outcomes of Adolescents and Young Adults in Adult HIV Care

We sought to describe virologic and clinical retention outcomes among a group of HIV-infected adolescents and young adults (AYA) newly established in an adult HIV clinic compared with matched HIV-infected adults. AYA demonstrated lower rates of HIV-1 virologic suppression and higher rates of HIV-1 viral rebound and loss to follow-up compared with adults. African American AYA had the lowest rates of virologic suppression and the highest rates of viral rebound. Adult providers should consider HIV-infected AYA, particularly African American HIV-infected AYA, to potentially be at high risk for poor clinical outcomes in adult care.

An evaluation of the impact of a self-care coping intervention on psychological and clinical outcomes in adolescents with newly diagnosed cancer

The demands of cancer treatment are particularly challenging for newly diagnosed adolescents. If attempts to cope with these demands are unsuccessful, adolescents may not comply with or may refuse treatment. As a result, their chances of survival are decreased. The purpose of this study, guided by the Adolescent Self-Sustaining Model, was to determine the effects of a three-part educational intervention designed to facilitate copying on psychological (hopefulness, hopelessness, self-esteem, self-efficacy and symptom distress) and clinical outcomes (treatment toxicity) among adolescents newly diagnosed with cancer. This two-site study used a longitudinal experimental two-group design with adolescents randomly assigned to the intervention or control group. Four measurement points spanning the first 6 months of treatment were included in the design. Of 93 eligible adolescents, 78 (46 females and 32 males) agreed to participate. No statistically significant differences between the intervention and control groups, or between male and female participants, were detected at any measurement point. Differences in scores over time within groups were noted. Explanations for the lack of group differences are offered, as are recommendations for strengthening the intervention and design for future testing.