Objective To explore the effectiveness of applying case leaded PBL in the teaching of obstetrics and gynecology.Methods Totally 80 (2006 grade) five-year clinical medicine students were divided into 2 groups (n =20) according to complete randomized designing principle.Case leaded PBL and traditional teaching methods were applied in the two groups respectively.Operation skill test,theoretic examination and questionnaires were used for evaluation and x2 was used to analyze the sample rate.Results Overall scores in final theoretic examination of PBL group were higher than those in traditional teaching group,but without significant difference (x2 =0.241,P > 0.05).Scores of operation skill test were higher in PBL group than in traditional teaching group,with significant differences (x2 =6.229,P < 0.05).Questionnaire results showed that satisfaction degree was higher in cases PBL group than in traditional teaching group,except that of ‘ systematical study’ item.Conclusions case leaded PBL teaching can not only enhance students' learning interests,intrigue their initiatives to improve practical ability,skills to communicate with patients and self-learning ability,but also enhance young teachers' coaching ability. Key words: Obstetrics and gynecology; Clinical teaching; Case lead; Problem-based learning