Clinical Effects Of Hyperbaric Oxygen Research Articles

The Clinical Effects of Hyperbaric Oxygen in the Treatment of Sudden Deafness

Objective: To observe the clinical effect of hyperbaric oxygen in the treatment of sudden deafness. Methods: Ninety-six patients with sudden deafness diagnosed by the otolaryngology department were divided into 2 groups which comprised of 48 patients in the conventional treatment group and the other 48 patients in the hyperbaric oxygen treatment group. Both groups were treated with methylcobalamin, vitamin B1, and ginkgo biloba extract. The patients in the hyperbaric oxygen treatment group were given hyperbaric oxygen therapy of 2.0 ATA once a day. Each course of treatment lasted 10 days and after two courses of treatment, the clinical efficacies of the two groups were compared. Results: After two courses of treatment, the effect of treatment in the hyperbaric oxygen treatment group was significantly better than that of the conventional treatment group. Conclusion: Hyperbaric oxygen therapy can effectively improve the hearing level of patients with sudden deafness and the overall effective rate of treatment.

Clinical Effect of Hyperbaric Oxygen in First Aid for Patients with Acute Carbon Monoxide Poisoning

Clinical Effect of Hyperbaric Oxygen in First Aid for Patients with Acute Carbon Monoxide Poisoning

Clinical effect of hyperbaric oxygen for patients with hypertension hemorrhage

Objective To study the clinical effect of hyperbaric oxygen for patients with hypertension hemorrhage.Methods 70 cases of hypertensive cerebral hemorrhage patients admitted in our hospital from June 2012 to June 2013 were randomly divided into experimental group and control group,35 cases in each group.The control group was given routine treatment,while the experimental group was given hyperbaric oxygen and routine treatment.After treatment,the clinical efficacy of the two groups,patients with Glasgow Coma Scale(GCS),the NIH Stroke Scale (NIHSS),Barthel Index (Barthel) and the edema area of two groups were observed and analyzed.Results After treatment,the total effective rate of the experimental and the control group was 88.6％,71.4％,showing a statistical significant difference (P ＜ 0.05); the GCS,NIHSS,Barthel score and the edema area of experimental group were significantly better than those of the control group (P ＜ 0.05).Conclusion Hyperbaric oxygen has significant clinical efficacy in postoperative recovery for patients with hypertensive cerebral hemorrhage after operation,it is worthy of clinical promotion. Key words: Hyperbaric oxygen; Hypertension hemorrhage; Clinical effect

In vitro effects of hyperbaric oxygen on sickle cell morphology

Study Objective: To determine in vitro whether hyperbaric oxygen has any effect on the morphology of sickle cells. Design: Prospective, in vitro, study, with each patient sample serving as its own control. Setting: University medical center. Patients: 10 children known to be homozygous for hemoglobin S. Interventions: Blood samples were obtained from 10 children during routine visits to the University sickle cell clinic. Blood samples were exposed to room air to achieve maximal sickling. Each sample was divided into control and study aliquots, and the study portions placed in a research hyperbaric chamber with 100% oxygen at 3 atmospheres absolute pressure for 15 min. Then smears were prepared from all samples at regular intervals and examined by technicians in the sickle cell clinic who were blinded as to the details of this study. Measurements: Percentages of normal cells, sickle cells and sickle forms were reported. Data were interpreted using t-tests. Main results: Hyperbaric oxygen appeared to have no effect on sickle cell morphology. Percentages of each cell type were unaffected by hyperbaric oxygen exposure. Conclusions: Hyperbaric oxygen appears to have no effect on the morphology of sickle cells in vitro. Other mechanisms may account for the beneficial clinical effects of hyperbaric oxygen in sickle cell crisis, although in vivo studies are warranted.

Modification of in vivo and in vitro TNF-alpha, IL-1, and IL-6 secretion by circulating monocytes during hyperbaric oxygen treatment in patients with perianal Crohn's disease.

Treatment of perianal inflammatory lesions in Crohn's disease (CD) is unsatisfactory and novel treatment modalities are pursued. We have recently reported a good clinical effect of hyperbaric oxygen (HBO) treatment in perianal CD. In the present study, seven patients with perianal CD were subjected to daily sessions of HBO in a multiplace hyperbaric chamber. Each patient received a total of 20 sessions during a time period of 1 month, and IL-1, IL-6, and TNF-alpha measurements were done several times during the initial sessions and after completing therapy. Pretreatment cytokine levels were elevated in patients compared to age-matched 10 normal controls. During the first 7 days of treatment, IL-1, IL-6, and TNF-alpha levels in supernatants of LPS-stimulated monocytes derived from patients' peripheral blood were decreased compared to pretreatment levels. Parallel measurements of serum IL-1 levels revealed an initial elevation and thereafter decreased levels, which remained low throughout the first week of HBO treatment. After completion of therapy, cytokine levels increased to pretreatment values. We conclude that alterations in secretion of IL-1, IL-6, and TNF-alpha may be related to the good clinical effect of HBO treatment in CD patients with perianal disease.