The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis. Polzer I, Schwann C, Volzke H, Mundt T, Biffar R. Clin Oral Investig 2012;16(2):333-51. Brian Laurence, DDS, PhD To determine (1) whether the number of teeth is related to all-cause and circulatory mortality and (2) whether replaced teeth are protective against all-cause or circulatory mortality Government of Germany (Grant #01ZZ9603, 01ZZ0103, and 01ZZ0403 ) Systematic review with meta-analysis Level 1: Good-quality, patient-oriented evidence Grade B: Inconsistent or limited-quality patient-oriented evidence