Observed climate change leads to the variations in the phenology, physiology, and biochemistry of grape berries, to a shift in the distribution of the grape plant areas and, as a result, to a change in the specialization of associated regions. Using the agroclimatic indicators for a comprehensive assessment of the climate change impact on viticulture, a comprehensive assessment of the grape growth conditions, potential quality of wine, and the climate-related risks in the Crimea and Donbass (on the example of Sevastopol and Artemovsk) over two 30-year periods (1961-1990 and 1991-2020) has been carried out. The results have shown a significant change in climatic conditions: an increase in heat availability in both regions and a decrease in frost susceptibility in the south of Donbass.