Introduction: Currently, global climate change and variability are one of a number of the challenges of agricultural production of smallholder farmers of developing countries including Ethiopia. Coffee is that the major crop that plays a foremost role in earning foreign revenue for Ethiopians. However, it needs an appropriate climate to offer yields properly. Thus, the study aimed to assess smallholder coffee producer’s adaptation strategies to global climate change and variability within the Mana district, South-western Ethiopia. Methodology: Primary data were collected from 377 coffee farmer households employing a simple sampling technique. Descriptive statistics like mean, variance, percent and frequency, and multivariate probit model were used for data analysis. Results: The result indicated that soil conservation, planting shade trees, adjusting harvesting dates, and improved coffee variety were the main climate change adaptation measures households employed within the study area. The outcomes of the model indicated that being male household head, household size, farm size, farming experience, educational level, frequency of extension contact, access to global climate change information, perception to global climate change, farmer-to-farmer extension, access to credit service, and participation of household in nonfarm activities were significant and positively influenced, but the age of household was negatively affected households within the adoption of adaptation options. Conclusion: Generally, a policy that promotes the adoption of planting shade trees, soil conservation, improved coffee variety, and adjusting harvesting dates should be encouraged within the study area.