BackgroundIncreasing complexity of treatment plans is associated with higher levels of caregiver burden in owners of dogs with skin disease. It is possible that elevated caregiver burden resulting from treatment complexity could, in turn, affect the veterinarian–client relationship.Hypotheses/ObjectivesWe expected that treatment complexity, caregiver burden, and the client’s perception of the veterinarian–client relationship would be related to each other. We also expected an indirect effect of caregiver burden on the cross‐sectional association between treatment complexity and the veterinarian–client relationship, and that this effect would be robust to adjustment for the dog’s skin disease course and severity.ParticipantsParticipants were 349 owners of dogs with skin disease recruited through online consumer panels.Materials and methodsCross‐sectional online assessments were completed for caregiver burden, treatment plan complexity, veterinarian–client relationship, and skin disease course and severity. Demographic information also was collected.ResultsThe indirect effect of caregiver burden on the relationship between treatment complexity and veterinarian–client relationship was statistically significant, accounting for 42.76% of the variance in the model. After controlling for disease severity and course, that effect remained statistically significant, accounting for 37.76% of the variance.Conclusions and clinical importanceFindings support the notion that greater treatment complexity is related to the owner’s perception of the veterinarian–client relationship via caregiver burden. Efforts to reduce caregiver burden by using the simplest effective treatment may benefit the veterinarian–client relationship.