A new library of Quinoline appended 1,2,3-triazole hybrids of biotic interest was synthesized using terminal alkynes containing quinoline moiety, benzyl amine based bromides, sodium azide via click chemistry protocol and were assessed for antimalarial and antimicrobial potential. All of the synthesized triazoles were characterized using different spectral techinques viz. FTIR, 1H NMR,13C NMR and HRMS. Antimalarial activity of the synthesized quinoline-triazole hybrids against the Plasmodium falciparum strain displayed modest to good results. The synthesized compounds also reflected good antimicrobial potential against four bacteria (Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli) and two fungi (Candida albicans, Aspergillus niger). Molecular docking studies and in-silico ADME (Absorption, Distribution, Metabolism and Elimination) analysis were also performed to check the binding and drug-likeliness of the synthesized compounds.