Clerodendrum Paniculatum Research Articles

Screening of aerial parts of the plant Clerodendrum paniculatum Linn for anti-anxiety activity

Screening of aerial parts of the plant Clerodendrum paniculatum Linn for anti-anxiety activity

Screening of aerial parts of the plant Clerodendrum paniculatum Linn for anti-anxiety activity

The present study was undertaken to investigate and validate the traditional claims of Clerodendrum paniculatum Linn for its anti-anxiety activity. C. paniculatum linn belongs to Verbenacae family. Ethnomedical importance of various species of Clerodendrum genus has been reported in various indigenous systems of medicines and folk medicines. It is used as a medicine for the treatment of sore eyes, gonorrhoea, urinary tract infection and kidney problems. Till date there are no reports available regarding its pharmacological properties of hence, it is therefore worthwhile to study the unrevealed properties of this plant. The shade dried aerial parts of plant were extracted by extracted using ethyl acetate, petroleum ether and aqueous as a solvent. Obtained extracts were subjected for phytochemical screening and antianxiety activity was studied using elevated plus maze and light and dark models. Results of the phytochemical screening revealed the presence of flavonoids, tannins, glycosides, saponins, and terpenoid like compounds. In addition, among the extracts studied for anti-anxiety activity of ethyl acetate extract shown significant activity comparable with standard drug, diazepam. Petroleum ether and aqueous extracts shown least anti-anxiety activity in comparison with the standard.

Screening of Aerial Parts of the Plant Clerodendrum paniculatum Linn for Anti-Convulsant Activity

The present study was undertaken for investigating and validating the traditional claims of Clerodendrum paniculatum Linn for its anti-convulsant activity. Clerodendrum paniculatumlinn belongs to verbenacae family. Ethno medical importance of various species of Clerodendrum genus has been reported in various indigenous systems of medicines and folk medicines. It is used as a medicine for the treatment of sore eyes, urinary tract, gonorrhoea and kidney problems. However pharmacological properties of plants have not yet been extensively studied, it is therefore thought worthwhile to study about the unrevealed properties of this plant. The aerial parts of plant are used for preparing extraction using ethyl acetate, petroleum ether and aqueous as a solvent. Shade dried, powdered (40 mesh size) leaves of Clerodendrum paniculatum Linn were extracted with ethyl acetate, petroleum ether and macerated with distilled water. On using solvent extraction phytochemical screening was analyzed, it reveals the presence of flavanoids, tannins, glycosides, saponins, and terpenoids like compounds. Anti-convulsant activity of ethyl acetate extract shows significant activity comparable with standard drug, Phyntoin. Petroleum ether and aqueous extracts shows little anti-convulsant activity.

Ethnobotanical uses, phytochemistry and biological activities of Clerodendrum paniculatum L. (Lamiaceae): A comprehensive review

Clerodendrum L. is an important genus in the family Lamiaceae in terms of its medicinal values and pharmacological properties. The genus comprises of more than 500 species distributed worldwide. In this review, we present an updated information on ethnobotanical uses, phytochemistry and biological activities of Clerodendrum paniculatum L. (Lamiaceae). The plant is one the most spectacular Clerodendrum species and is grown commonly for ornamental purpose. The plant is reported to have ethnomedicinal importance as the plant is used as remedy for ailments and disorders such as wounds, typhoid, snakebite, jaundice, giddiness, malaria, anemia and hemorrhoids. Various phytochemicals such as rutin, quercetin, β-sitosterol, β-amyrin, lupeol, oleanolic aldehyde acetate, stigmasta-4,25-dien-3-one, and (3β)-stigmasta-4,22,25-trien-3-ol have been identified in C. paniculatum. The plant is shown to exhibit biological activities such as antimicrobial, antioxidant, anthelmintic, anti-inflammatory, antimutagenic, cytotoxic, hypolipidemic, insecticidal and anti-ageing activity.
 Keywords: Clerodendrum paniculatum L., Ethnobotanical, Traditional, Phytochemicals, Biological activities

In vitro anti-inflammatory, mutagenic and antimutagenic activities of ethanolic extract of Clerodendrum paniculatum root.

Clerodendrum paniculatum L. (Family Verbenaceae) has been used as an antipyretic and anti-inflammatory drug in traditional Thai medicine. This present study investigated the in vitro anti-inflammatory, mutagenic and antimutagenic activities of the ethanolic extract of C. paniculatum (CPE) dried root collected from Sa Kaeo Province of Thailand. Murine macrophage J774A.1 cells were stimulated by lipopolysaccharide (LPS) to evaluate nitric oxide (NO), tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) production in the anti-inflammatory test while the mutagenic and antimutagenic potential was performed by the Ames test. The outcome of this study displayed that the CPE root significantly inhibited LPS-induced NO, TNF-α, and PGE2 production in macrophage cell line. In addition, the CPE root was not mutagenic toward Salmonella typhimurium strain TA98 and TA100 with and without nitrite treatment. Moreover, it inhibited the mutagenicity of nitrite treated 1-aminopyrene on both strains. The findings suggested the anti-inflammatory and antimutagenic potentials of CPE root.

Ethnomedicine for Scabies and Skin diseases in Khammam district of Andhra Pradesh

The paper deals with 77 species of plants covering 68 genera and 37 families used for curing common skin diseases by the tribals of Khammam district of Andhra Pradesh. Caesalpiniaceae is the dominant (9 sps) family followed by Fabaceae (6 sps), Euphorbiaceae (5 sps), Zingiberaceae (4 sps), Mimosaceae, Poaceae, Asteraceae, Lamiaceae (with 3sps each) and others. Habit-wise analysis showed the dominance of herbs followed by trees, shrubs and climbers. Morphological analysis showed maximum utilization of leaf in 37 practices followed by whole plant (11), fruit, seed (7 each), stem bark, root (6 each), flower (4), rhizome, stem (3 each) and tuber (1). Caesalpinia sappan, Caralluma umbellata, Clerodendrum paniculatum, Grewia flavescens, Leucas aspera, Merremia aegyptia and 41 practices were found to be new.

In vitro and in vivo antiinflammatory activity of Clerodendrum paniculatum linn. leaves

Preliminary phytochemical screening showed the presence of terpenes, flavonoids, tannins, alkaloids, phenolic acid, sterols, and glycosides. This study was intended to evaluate the antiinflammatory activity of various extracts of fresh leaves of Clerodendrum paniculatum Linn experimentally by in vitro (human red blood cell membrane stabilization method) and in vivo methods (0.1 ml of 1% w/v carrageenan-induced rat paw oedema model). Petroleum ether, chloroform, ethyl acetate, alcohol, and aqueous extracts were screened for in vitro antiinflammatory activity. Petroleum ether and chloroform extracts which showed, best in vitro antiinflammatory activity was screened for in vivo antiinflammatory activity at the dose level of 200 and 400 mg/kg. Indomethacin at the dose level of 10 mg/kg was used as reference standard drug. Both the extracts showed a dose dependent significant (P<0.001) reduction in paw edema when compared to the control, at all the time intervals and comparable to indomethacin (reference standard) treated group. The results of the present study demonstrate that petroleum ether and chloroform extracts possess significant (P<0.001) antiinflammatory potential which provide scientific basis for the traditional claims of Clerodendrum paniculatum Linn leaves as an antiinflammatory drug.

THE PORIFERASTA COMPOUND-5,22E,25-TRIEN-3-Oβ FROM Clerodendrum paniculatum LEAF AS INDUCER AGENT OF SYSTEMIC RESISTANCE ON RED CHILLI PLANT Capsicum annuum L FROM CUCUMBER MOSAIC VIRUS (CMV

The poriferasta-5.22E.25-trien-3β-ol compound of leaves of this plant Clerodendrum paniculatum has activity as an inducer agent of plant systemic resistance of red plant toward Cucumber Mosaic Viruses (CMV), the inhibition activity compound shows 82% inhibition activity at 300 ppm. The structure of these compound were determined on the basis of spectroscopic data including UV, IR, 1H-NMR, 13C-NMR and 2D-NMR Keywords: Poriferasta-5.22E.25-trien-3β-ol, Clerodendrum paniculatum, induction of systemic resistance, CMV

Diet of the giant African land snail Archachatina marginata Swainson, 1821, in Ivory Coast: preferences and estimate of damages

Summary . — An inventory of wild plants consumed by the edible giant snail Archachatina marginata was compiled and tested in the laboratory. Juvenile and adult snails were fed on the four most edible plants during a dietary preference experiment. The chemical components of these plants were also determined. Damage caused by these snails was estimated according to daily consumed quantity, thus mean number of young and adult leaves consumed per day by these snails. Plant diversity was also noted and field observations conducted within the forest of the University of Abobo-Adjamé (Abidjan, Ivory Coast). A. marginata consumed miscellaneous wild plants but prefers Clerodendrum paniculatum and Laportea aestuans which offered the best phosphorus, sodium and potassium contents. The plants most consumed were Laportea aestuans, Phaulopsis falcisepela and Palisota hirsuta. This snail is a secondary forest flora pest and has an influence on the plant biodiversity in this forest.

Nectar Robbing and Pollination of Lantana camara (Verbenaceae)

Floral robbers are categorized as nectar-foraging, nectar-foraging-perforating, and pollen-foraging. Trigona fulviventris is a nectar-foraging-perforating robber of yellow flowers of Lantana camara. Flower head maturation of L. camara is centripetal and flowers turn from yellow to reddish-orange, resulting in inflorescences of central yellow flowers with peripheral orange and reddish-orange ones. In the laboratory, seed set occurs only after cross-pollination; in the field, the presence of orange and reddish-orange flowers is related to decreased nectar robbery of yellow flowers. Co-evolution of L. camara, its butterfly pollinators, and T. falviventris has presumably involved increased nectar production of this plant to feed both its pollinators and robber. THIS STUDY WAS MADE because of our limited knowledge of the pollination ecology of Latana camara; furthermore, it is the first record of nectar robbery by the stingless bee, Trigona (Trigona) fulviventris, or any other meliponine apid. T. fulviventris is a nectar-foraging-perforating robber of L. csmara which bites holes below the bases of the stamens (fig. 1) and probably effects little if any cross-pollination. Possible effects of its robbing behavior on butterfly pollinators and the general pollination ecology of this plant in Costa Rica were investigated. L. camara is a woody shrub distributed throughout tropical Central America; it has also become naturalized in other tropical and subtropical areas. Flowers gradually turn from yellow to reddish-orange in three days in the plants studied. Dronamraju (1958, 1960) reported that butterflies preferentially visit yellow flowers of Lantana and Muller (1877) hypothesized that having varicolored flowers makes inflorescences more visually attractive in potential pollinators. In Costa Rica, in addition to Lawtana, Trigona spp. rob nectar by perforation from Hamelia patens, Clerodendrum paniculatum, Rondeletia, and Malvaviscus. In other parts of the world, other genera of bees (e.g. Bombus, Apis, Xyloco pa, and Megachile) are or are likely to be nectar-foraging-perforating robbers of various genera of plants having flowers with tubular corollas (see for examples, Sprengel 1793, Darwin 1876, Kerner 1895, Porch 1924, Meidell 1944, Schremmer 1955, Meeuse 1961, Hurd and Linsley 1963, Macior 1966, 1970, 1971, Faegri and van der Pijl 1971).