Cleared Hepatitis Research Articles

Studies on the HBV carriers who became seronegative during the follow-up

Four-hundred and seventy-eight hepatitis B virus (HBV) carriers were followed for more than 5years. Thirty-six cases (7.5%) cleared hepatitis B surface antigen (HBsAg) from serum during the observation period. In these 36 cases, the investigation of HBV carriers in relation to the clinical course and HBV markers was performed.1) Fourteen of them (Group I) developed anti-HBs and other 22 (Group II) remained anti-HBs free. The difference of the two groups was significantly related to the age. Group II suggested to have possibility to develop anti-HBs in the future.2) The correlation between the clearance of HBsAg and other HBV markers (HBeAg, anti-HBe, anti-HBc) was not found.3) Annual clearance rate of HBsAg was 1.27%. Annual clearance rates of various age groups exhibited significant rise in groups over 40 years old.