Clear Cell Adenocarcinoma Of Cervix Research Articles

Clear cell adenocarcinoma of the cervix and its mimickers - A series of 19 cases from a tertiary care referral centre in India.

Clear cell adenocarcinoma (CCAC) of cervix is a rare subtype of endocervical adenocarcinoma that accounts for 4% of all cervical adenocarcinoma with many morphological mimickers. Retrospectively study cases of cervical clear cell adenocarcinoma of the cervix. Clinical profile and pathological features of CCAC of the cervix diagnosed between 2018-2022 were retrospectively analyzed.The database of the Department of Pathology of our institute was systematically searched for patients diagnosed with clear cell adenocarcinoma of the cervix during 2018-2022.A total of 19 patients were studied with the mean age of patients being 53.72 years (range 25 -84 yrs,standard deviation-25.9) and median tumor size being 5.6cm. Lymph node metastasis was identified in 33.3% and distant metastasis were seen in 20% of the cases. Staging could not be done in 4 cases.FIGO staging of the cases included IB1(2 cases), IB2(2 cases), IIB (3 cases),IIIA (1 case)IIIB(4 cases),and IV(3 cases). On histopathological evaluation, heterogeneous architectural pattern comprising of tubulocystic, solid, and papillary patterns were seen in 13 cases (13/19,68.4%). Pure tubulocystic (3/19,15.7%), pure papillary (2/19,10.5%), and pure solid patterns (1/19,5.3%) were also identified. Tumor cells with clear cytoplasm ranged from 5% to 95%. Nuclear atypia was moderate to marked in all the cases (19/19,100%). Mitotic activity varied from 1/10hpf to 20-22/10hpf. By immunohistochemistry, tumor was positive for Napsin A in all the cases,p16INK4a was negative in majority of cases (15/19,78.9%) and ER was negative in 14 cases (14/19,73.7%) .p53 showed wild type staining except for one case . Clear cell adenocarcinoma being a rare subtype of cervical adenocarcinoma, needs to be differentiated from other Human Papilloma Virus(HPV) independent adenocarcinomas (gastric and mesonephric types) and benign entities such as endocervical glandular Arias-Stella reaction. Judicious use of a panel of immunostains is often helpful.

Primary Clear Cell Adenocarcinoma of the Uterine Cervix in a 14-Year-Old Virgin Girl: Case Report

Cervical cancer is rare in adolescent and pediatric populations, with adenocarcinoma being the most commonly reported. Clear cell adenocarcinoma of the uterine cervix accounts for only 4% of all adenocarcinoma cases, and about two-thirds are associated with intrauterine diethylstilbestrol (DES) exposure. We report the case of a 14-year-old virgin girl who presented with a 1-month-long history of abnormal vaginal bleeding and lower abdominal pain. Transabdominal pelvic ultrasound examination revealed the presence of an irregular, homogeneous cervical mass that was 7 cm in size. Therefore, a magnetic resonance imaging (MRI) scan was performed to establish the origin of the tumor and its relationship to adjacent pelvic organs. Furthermore, a vaginoscopy was performed to identify the tumor, and a cervical biopsy was performed. Immunohistochemical and anatomopathological studies resulted in the diagnosis of non-HPV(Human Papilloma Virus)-related clear cell adenocarcinoma of the cervix. Following the oncological examination, she was admitted for radiotherapy. The patient had no maternal history of DES exposure in utero. Even though the number of cases in the literature is low, most of the virgin girls diagnosed with clear cell adenocarcinoma of the cervix have a fatal prognosis because of the delay in making a correct diagnosis.

Clear cell adenocarcinoma of the uterine cervix in an 18 year-old pregnant female

•An 18 year old nulliparous woman was diagnosed with clear cell adenocarcinoma of the cervix in pregnancy.•LEEP conization at 33.3weeks gestation led to premature rupture of membranes. Following cesarean section, a radical hysterectomy was performed.

Clear-cell adenocarcinoma of the uterine cervix in a 17-year-old adolescent

This report describes the case of the youngest Japanese person to be diagnosed with endocervical clearcell adenocarcinoma. In September 2005, a 17-year-old female adolescent visited a physician because of vaginal bleeding. A cervical tumor was discovered, and the patient was referred to our outpatient department. Vaginal examination showed a bleeding tumor approximately 1.5 cm in size protruding from the cervical os. The cytological finding of the uterine cervix was positive for malignancy, and the histological diagnosis by punch biopsy was clear-cell adenocarcinoma of the uterine cervix. A radical abdominal hysterectomy and pelvic lymphadenectomy were performed on October 30. Macroscopic findings showed a tumor, 1.5 cm in diameter, growing from the right side of the uterine cervix. The pathological diagnosis was clear-cell adenocarcinoma of the cervix (PT1b1NR0M0). The patient was discharged from our hospital without any adjuvant therapy. No signs of recurrence have been detected in the 2-year follow up.

Gynecologic Oncology. Fundamental Principles and Clinical Practice

Gynecologic Oncology. Table of Contents. Part I Fundamental Principles.. Training of the Gynecologic Oncologist. Epidemiology of Gynecologic Cancer: 1 Cervix. Epidemiology of Gynecologic Cancer: 11 Endometrium, Ovary, Vagina, Vulva. Viruses and Cancer. Carcinogenesis. Quantitative Pathology. The Immune System and Gynecologic Cancer. Oncological Endocrinology. Pharmacology and Selection of Cytotoxic Drugs. Basic Parameters of Radiotherapy (Radiation. Physics and Biology). Future Prospects in Radiotherapy in Gynecologic Oncology. A Statistical Basis to Oncological Enquiry. Trials. Part Ii Diagnostic Aids. Diagnostic Cytopathology. Colposcopy of Cervix. Colposcopy of Vulva and Vagina. Diagnostic Hysteroscopy. Lymphography, Arteriography and Venography . Magnetic Resonance Imaging (Mri), Computerized Axial Tomography (Cat) Scanning and Immunoscintigraphy. Ultrasound. Laparoscopy. Needle Biopsy. Surgical Staging: New Approaches. Tumor Markers. Part Iii Tumors of Vulva and Vagina. Pathology of Malignant Tumors of Vulva and Vagina. Intraepithelial Neoplasia of Vulva. Early Invasive Carcinoma of Vulva: Definition, Clinical Features and Management. Invasive Tumors of Vulva: Clinical Features, Staging and Management. Intraepithelial Neoplasia of Vagina. Microinvasive Carcinoma of Vagina. Invasive Tumors of Vagina: Clinical Features and Management. Part Iv Tumors of Vagina and Cervix and Related Abnormalities in Young Females Exposed to Diethylstilbestrol (Des). Clear Cell Adenocarcinoma of Cervix and Vagina and Des Related Abnormalities. Squamous Neoplasia in Women Exposed to Synthetic Nonsteroidal Estrogens. Part V Carcinoma of Cervix. Control of Carcinoma of Cervix By Exfoliative Screening. Pathology of Cervical Squamous and Glandular. Intraepithelial Neoplasia. Cervical Squamous and Glandular Intraepithelial Neoplasia: Clinical Features and Review of Management. Pathology of Early Invasive Squamous and Glandular Carcinoma of Cervix (Figo Stage Ia). Early Invasive Squamous and Glandular Carcinoma of Cervix (Figo Stage Ia): Clinical Features and Management. Pathology of Clinical Invasive Carcinoma of Cervix. Clinical Invasive Carcinoma of Cervix: Clinical Features, Diagnosis, Staging and Pretreatment Evaluation. Clinical Invasive Carcinoma of Cervix: Place of Radiotherapy as Primary Treatment. Clinical Invasive Carcinoma of Cervix: Place of as Primary Treatment . Clinical Invasive Carcinoma of Cervix: Combined Radiotherapy and as Primary Treatment. Clinical Invasive Carcinoma of Cervix: Integration of Chemotherapy with Local Treatments. Advanced and Recurrent Carcinoma of Cervix. Part Iv Carcinoma of Endometrium and Its Precursors. Pathology of Premalignant Lesions of the Endometrium Endometrial Hyperplasia and Adenocarcinoma in Situ. Premalignant Lesions of the Endometrium: Clinical Features and Management. Pathology of Endometrial Carcinoma. Carcinoma of Endometrium (Figo Stages I & Ii) Clinical Features and Management. Advanced (Figo Stage Iii & Iv) and Recurrent Carcinoma of Endometrium. Part Vii Uterine Sarcomas. Pathology of Uterine Sarcomas. Uterine Sarcomas: Clinical Features and Management. Part Viii Tumors of Fallopian Tube and Broad Ligament. Pathology of Tumors of Fallopian Tube and Broad Ligament. Malignant Tumors of the Fallopian Tube: Clinical Features, Staging and Management. Part Ix Tumors of Ovary. Pathology of Malignant and Borderline (Low Malignant Potential) Epithelial Tumors of Ovary. Malignant and Borderline Epithelial Tumors of Ovary: Clinical Features, Staging, Diagnosis, Intraoperative Assessment and Review of Management. Pathology of Malignant Germ Cell Tumors of Ovary. Malignant Germ Cell Tumors of Ovary: Clinical Features and Management. Pathology of Malignant Gonadal Stromal Tumors of Ovary. Malignant Gonadal Stromal Tumors of Ovary: Clinical Features and Management. Malignant Mull Erian and Miscellaneous Mesenchymal Tumors of Ovary (Ovarian Sarcomas). Metastatic Tumors of Ovary. Part X Presacral Tumors. Presacral Tumors: Anatomy, Classification, Clinical Features and Management. Part Xi Trophoblastic Tumors. Pathology and Classification of Trophoblastic Tumors. Trophoblastic Tumors: Diagnostic Methods, Epidemiology, Clinical Features and Management. Part Xii Miscellaneous Malignant Tumors of Female Genital Tract. Genital Tract Malignancy in the Prepubertal Child. Melanoma of Female Genital Tract. Part Xiii Malignant Tumors in Pregnancy. Malignant Disease in the Pregnant Woman. Part Xiv Surgical Technique. Physical and Surgical Principles of Carbon Dioxide. (Co2) Laser Surgery in the Lower Genital Tract. Co2laser Surgery for Intraepithelial Neoplasia of Cervix. Cryosurgery. Electrocoagulation Diathermy. Conization of the Cervix. Abdominal Incisions and Sutures in Gynecologic Oncological Surgery. Surgery for Invasive Carcinoma of Vulva. Conservative Surgery for Stage I Carcinoma of Vulva. Vaginal Operations 1 Schauta 11 Vaginectomy. Extensive Abdominal Radical Hysterectomy and Bilateral Lymphadenectomy. with Pelvic Lymphadenectomy. The Tokyo Method. for Carcinoma of Endometrium. Pelvic Exenteration. Surgery for Carcinoma of Ovary. Surgery for Carcinoma of Ovary: Extrapelvic Cytoreduction. Part Xv Management of Complications of Therapy. (Surgery and Radiotherapy). Postoperative Care and Complications. Urological and Intestinal Complications of Surgery and Radiation Therapy for Pelvic Malignancy. Part Xvi Surgical Reconstruction of the Gynecologic Oncology Patient. Vulvar-Vaginal Reconstruction. Urinary and Rectal Continence Saving Operations. Part Xvii After Care. Gynecologic Pain. Sexual Morbidity Following Gynecologic Cancer. The Psychological Processes of Recovery from Gynecologic Cancer. Palliative Care: The Care of the Patient with Far Advanced Gynecologic Cancer. Attitudes to Dying. Index

A fatal case of stilboestrol associated clear cell adenocarcinoma of the vagina

SummaryIn the United States of America, over 400 cases of clear cell adenocarcinoma of cervix and vagina have been reported (Herbst, 1981), two-thirds of these having a documented association with prenatal exposure to stilboestrol. The first description of a stilboestrol associated neo-plasma of this type from the United Kingdom was in 1978 and it was then estimated that there were a further 10 latent cases in Great Britain (Monaghan and Sirisena, 1978); two of these have since become overt (Dewhurst et al., 1980; Davis et al., 1981) and we record here a third in which there were several unusual features and which proved to be the first reported fatality from this type of neoplasm in Britain.