Abstract Aim To assess the treatment results, complications and the quality of life of patients after anterior separation hernioplasty. Material & Methods comparative analysis of complications and quality of life of 96 patients with giant postoperative ventral hernias after anterior separation plastic by using polypropylene mesh endoprosthesis. Description of method of implant fixation is given, analysis of complications and quality of life of patients is given. The Clavien-Dindo scale and the EuroHS QoL score by EHS were used to investigate complications in the first 30 days. Results wound complications were observed in 11.4% (p < 0.01), general complications 4.2% (0.05), hernia recurrence rate1.0% (p < 0.01), death 1.0% (p < 0.05). Most patients (n = 71, 74%) experienced a significant reduction in pain intensity, increased physical activity, and satisfaction with appearance at 3 months post-surgery. Conclusions study results showed low percentage of wound complications, relapses, and the significant improvement of the quality of patient's life.